Myasthenia gravis: Lung-Function Studies without and with Edrophonium Chloride

Magyar, P.; Szathmáry, I; Szobor, A

doi:10.1159/000115054

Cited by 7 publications

(2 citation statements)

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“…Edrophonium is the agent commonly used for the anticholinesterase test because of its rapid onset (30 s) and short duration (about 5 min) [11]. If there is unequivocal improvement in an objectively weak muscle, the test result is considered to be diagnostic [12].…”

Section: Discussionmentioning

confidence: 99%

Respiratory Failure due to Vocal Cord Paresis in Myasthenia gravis

Teramoto

Kuwabara²,

Matsubara³

2002

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This report describes a female patient with myasthenia gravis who developed respiratory failure due to vocal cord paresis. The diagnosis was delayed due to the absence of other myasthenic symptoms (e.g. ptosis, muscle weakness and dysphagia). On direct laryngoscopy, her vocal cords were seen to be in the paramedian position and to move apart after the intravenous injection of edrophonium. The patient initially presented with ocular myasthenia and later returned with isolated respiratory failure. A review of the pertinent literature revealed few reports on myasthenia gravis presenting in this manner.

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Section: Discussionmentioning

confidence: 99%

Respiratory Failure due to Vocal Cord Paresis in Myasthenia gravis

Teramoto

Kuwabara²,

Matsubara³

2002

Respiration

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“…While the investiga tion of any muscular function -such as that of the chewing muscles, breathing muscles or the skeletal muscle group (9,10,20) -may have diagnostic significance, the diagnosis of MG is based primarily on the weakness and chronic fatigability of the external eye muscles. The reason for this -apart from the frequency (90%) of the manifested ocular symptoms -is that the latent ocular symptoms may be provoked comparatively easily.…”

mentioning

confidence: 99%

Myasthenia Gravis: the Effect of Tensilon® on the Caloric Nystagmus Response

Szathmáry¹,

Simon²,

Szobor³

et al. 1979

ORL

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The nystagmus response evoked by thermic vestibular stimulation on 25 patients with myasthenia gravis and on 10 control persons was investigated using the photoelectronystagmographic method before and after administration of Tensilon®. On the basis of 19 nystagmograms (capable of being evaluated) it was found that the test is of diagnostic value when combined with abstinence from drugs, furthermore, it may indicate under- or overtreatment of patients taking drugs. Excluding the drug-resistant, ‘burned out’ cases, a certain correlation may be observed between the magnitude of the reaction evoked by Tensilon and the severity of the clinical condition independent from the existence of ocular symptoms. The advantage of the test, apart from being numerically measurable, is that it can be repeated because of its non-invasive nature causing no physical burden to the patient. Its disadvantage is that it cannot be applied in cases with a pre-existent difference in vestibular tonus ––20% in the material tested.

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