Myasthenia gravis, paraneoplastic pemphigus and thymoma, a rare triade

Winkler, David T.; Strnad, Pavel; Meier, Markus; Roten, S.; Went, Philip; Lyrer, Philippe; Steck, A. J.

doi:10.1007/s00415-007-0588-6

Cited by 17 publications

(13 citation statements)

References 13 publications

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“…It is occasionally associated with other autoimmune diseases including pemphigus . Five human cases and one feline case of PNP with MG have been reported so far, four of which had thymoma and two had CD . MG and pemphigus associations seemed sporadic in our study, and among the patients with PV and PF who we examined, none complained of any typical muscle weakness.…”

Section: Discussionmentioning

confidence: 43%

“…[2][3][4][5] Unlike paraneoplastic neurological syndromes, autoimmunity aroused by tumour antigens against shared counterparts in the nervous system, 6,7 little is known regarding neurological involvement in PNP. Sporadically in the literature we have encountered PNP complicated with MG, [8][9][10][11][12][13] but these reports did not draw much attention as most of the associated tumours were thymoma, which is known to develop in at least 10-15% of cases of MG. 14 Recently a second case of PNP with CD and MG was reported, after the first one in 1999, suggesting a putative alternative linkage of PNP, MG and associated neoplasms. 8,11 The common background upon which these complications are based is autoantibodies targeting various tissues and organs.…”

mentioning

confidence: 99%

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Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Wang

et al. 2015

Br J Dermatol

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Section: Discussionmentioning

confidence: 43%

mentioning

confidence: 99%

Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Wang

et al. 2015

Br J Dermatol

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“…A TAP patient reported by Zhang et al (5) was successfully treated with complete removal of the thymoma after presenting with preoperative respiratory symptoms. Winkler et al (6) published a case report about a patient with a rare triad of thymoma, myasthenia, and TAP. The patient reached the obvious clinical resolution of myasthenic and pemphigoid symptoms four months after thymectomy, without recurrence during the follow-up period.…”

Section: Discussionmentioning

confidence: 99%

Robotic trans-subxiphoid extended thymectomy in a patient with thymoma-associated pemphigus

et al. 2017

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We herein firstly reported that a patient with thymoma-associated pemphigus (TAP) underwent a robotic-assisted trans-subxiphoid thoracoscopic extended thymectomy and then achieved stable resolution.The patient, a 47-year-old male, was first admitted to our hospital owing to stomatitis and bullae of the trunk after four months' prednisone treatment. On admission, chest computed tomography (CT) revealed an anterior-mediastinal mass and it was initially diagnosed as a thymoma. He was positive for anti-BP (bullous pemphigoid)-180 antibody and anti-desmoglein 3 antibody. Then, a robotic-assisted thymectomy was performed, following which, the anti-BP-180 and anti-desmoglein 3 antibody titres have declined. The patient's mucocutaneous lesions improved, and the steroid dose was gradually decreased from 60 to 40 mg/day.According to previous reports, and the experience of the presented case, we therefore believe that early extended thymectomy is an effective therapeutic intervention for TAP.

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“…In the past, myasthenia gravis (MG) has been anecdotally linked with PNP through isolated case reports [56,57]. A recent study has suggested that a robust association does in reality exist between these two entities [58•].…”

Section: Paraneoplastic Pemphigusmentioning

confidence: 99%

Skin Manifestations of Internal Disease in Older Adults

Markus¹,

Perry²,

Lear³

2015

Curr Geri Rep

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The skin is the largest and most visible organ in the body and can give diagnostic clues of systemic illness. These clues often become obscured through the normal aging process. The purpose of this review is to give an overview of the normal skin changes seen with aging and then discuss new findings with regards to cutaneous signs of systemic disease in the elderly. We performed a literature search on cutaneous manifestations of internal disease and limited our search to articles published within the last 5 years. We then narrowed down the articles on conditions that primarily affect the adults over the age of 65; conditions commonly seen in the elderly as well as new findings which we felt were of great significance. Ultimately, we hope to update the reader on new cutaneous diagnostic tools of internal disease.

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Myasthenia gravis, paraneoplastic pemphigus and thymoma, a rare triade

Cited by 17 publications

References 13 publications

Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Prevalence of myasthenia gravis and associated autoantibodies in paraneoplastic pemphigus and their correlations with symptoms and prognosis

Robotic trans-subxiphoid extended thymectomy in a patient with thymoma-associated pemphigus

Skin Manifestations of Internal Disease in Older Adults

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