Mycétomes des Ouest-Africains non résidants en Côte d’Ivoire

Adoubryn, Koffi Daho; Koffi, K; Doukouré, Brahima; Troh, E.; Kouadio-Yapo, C.G.; Ouhon, J.; Assoumou, A.; Ferly-Therizol, M; Diomandé, Mohamed; Hondé, M.; Kone, M.

doi:10.1016/j.mycmed.2009.11.007

Cited by 11 publications

(8 citation statements)

References 9 publications

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“…However, the predominance of eumycetoma cases in our series is in agree with the findings of Ndiaye et al, who have reported 70% eumycetoma versus 30% actinomycetoma in Senegal [12]. Other reports confirm the relatively high prevalence of eumycetoma in the West-African region [20,21]. Most of cases in our study were diagnosed based on clinical aspects and grain color.…”

Section: Discussionsupporting

confidence: 92%

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Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018

Sow¹,

Ndiaye

Sarr

et al. 2020

PLoS ONE

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Mycetoma is a neglected tropical disease caused by various actinomycetes or fungi. The disease is characterized by the formation of tumor like-swellings and grains. Senegal is an endemic country where mycetoma cases are under-or misdiagnosed due to the lack of capacities and knowledge among health workers and the community; and where the management of eumycetoma, burdened by a high amputation rate, is currently inadequate. This study aimed to update data on the epidemiology of mycetoma cases diagnosed in three hospital centres in Senegal over a 10 years-period. A total of 193 patients, diagnosed from 2008 to 2018, were included in the study. The most frequent presentation was eumycetoma (47.2%); followed by actinomycetoma (36.8%); it remained undetermined in 16.1% of the patients. The mean age was 38.3 years (68.4% of the patients were between 15 and 45 years-old); the male: female ratio was a 2.94; and most were farmers. One hundred fifty-six (80.8%) patients had used phytotherapy before attending the hospital. Mycetoma was mainly located to the lower limbs (91.2%). Grains were observed in 85% of the patients; including white (25.6%) and yellow (4.3%) grains. The etiological diagnosis was complex, resulting in negative direct microscopy, culture and/or histopathology findings, which explains that 16.1% remained uncharacterized. In most of cases, actinomycetoma were treated with a combination of cotrimoxazole, amoxicillin/clavulanic acid, and streptomycin; whereas eumycetoma cases were treated with terbinafine. The surgery was done in 100 (51.8%) of the patients including 9 in actinomycetoma, 78 in eumycetoma and 13 in undetermined form. The high number of uncharacterized mycetoma in this study, the delay in attending a qualified health-care facility, and the lack of available adequate antifungal drug, point out the need to strengthen mycetoma management capacities in Senegal.

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Section: Discussionsupporting

confidence: 92%

“…The culture has isolated only 56 species (29%). Actinomadura pelletieri was the most isolated species (24) followed by Madurella mycetomatis (21), Falciformispora senegalensis (5), Streptomyces somaliensis (2), Scedosporum apiospermum (1), Penicillium sp.…”

Section: Resultsmentioning

confidence: 99%

Mycetoma epidemiology, diagnosis management, and outcome in three hospital centres in Senegal from 2008 to 2018

Sow¹,

Ndiaye

Sarr

et al. 2020

PLoS ONE

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“…Oladele et al herders, field workers, nomads, those who walk barefoot and those in the third and fourth decades of life. 9 Although not confined to any occupational group, the majority of patients live in rural areas and are generally engaged in outdoor occupations that involve direct contact with soil or thorns, such as farmers, shepherds, fishermen and breeders. 9,20,81…”

Section: Distribution Of Mycetoma In West Africamentioning

confidence: 99%

“…farmer, agriculturist), poor health education and poor accessibility to healthcare facilities. 3,9,14,[16][17][18] An impaired immune system has not been implicated as a risk factor. Affected individuals usually have a normal functioning immune system.…”

Section: Risk Factorsmentioning

confidence: 99%

Mycetoma in West Africa

Oladele

Ly²,

Sow

et al. 2021

Transactions of the Royal Society of Tropical Medicine and Hygiene

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Background Mycetoma is a neglected disease, which is socioeconomically important, and with the possibility of permanent disability in infected persons if not treated early. This is especially true in resource-limited settings such as West Africa, where there is a lack of facilities and skilled personnel to make a definitive laboratory diagnosis. Countries in West Africa have similar climatic conditions to Sudan. The majority of patients seek medical care very late, when there is already bone involvement, resulting in amputations. This results in poor capture of the true burden of the problem in the literature. Methods A review of the literature revealed about 2685 documented cases in West Africa from 1929 to 2020; from 15 out of 16 countries, Senegal accounted for 74.1% (1943) of cases in the subregion. Results The majority of lesions were found on the foot; however, other body parts were also reported. Rural dwellers accounted for most cases. Only 547 (20.4%) cases had identified isolates reported. Actinomycetoma accounted for 47.9% of cases, eumycetoma 39.7% and unidentified pathogens 12.4%. Actinomadura pelletieri was the predominant pathogen isolated (21.4%; 117 isolates). Conclusion There is a dire need for capacity building, provision of facility and health education to raise awareness of this debilitating disease in West Africa.

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“…It is important to stress the importance of long-term follow-up before concluding to the effectiveness of a treatment. Develoux et al recommended at least 3 years of follow-up, the risk for relapse decreasing sharply after this period [1] (a case of relapse 12 years after surgery has nevertheless been reported) [40].…”

Section: Therapeutic Aspectsmentioning

confidence: 99%