Mycobacterial Infection of the Head and Neck: Presentation and Diagnosis

Al-Serhani, Awad

doi:10.1097/00005537-200111000-00027

Cited by 89 publications

(64 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Anosmia is rare [3] and was noted in one of our patients. However, unilateral lesions, non response to medical treatment, long-term evolution and the possible association with a decline in general health should alarm [17]. Similarly, there are no specific endoscopic aspects of TB infection.…”

Section: Discussionmentioning

confidence: 99%

Naso-Sinusal Tuberculosis: 3 Cases Report

Mardassi¹,

Dimassi²,

Nefzaoui³

et al. 2016

Nova J Med Biol Sci

View full text Add to dashboard Cite

Introduction: Tuberculosis remains a real public health problem in Tunisia. Extrapulmonary localizations account for 20 to 30% of tuberculosis disease, dominated by the node, osseous and urogenital localization. Case Report: The authors present three cases of nasosinusal tuberculosis, an unusual and rare localization of the disease, in a man and 2 women aged respectively of 30, 65 and 36 years. Results: The main symptoms were dominated by nasal obstruction, posterior throwing and dental pain. CT-scan showed a filling of the nasosinusal cavities with various stages of bony lysis. In all the cases, tuberculosis was confirmed histologically after an endoscopic middle meatotomy. Investigations looking for tuberculosis elsewhere were negative in all cases. Treatment was based on anti-tuberculosis drugs during 9 to 12 months. The evolution was favourable in all the cases. Conclusions: Nasosinusal tuberculosis is a rare chronic infection associating often variable levels of bony lysis. Histological exam remains the best way to confirm it. Therapy is based on anti-tuberculosis drugs. Medical investigations must usually search other localizations of the disease.

show abstract

Section: Discussionmentioning

confidence: 99%

Naso-Sinusal Tuberculosis: 3 Cases Report

Mardassi¹,

Dimassi²,

Nefzaoui³

et al. 2016

Nova J Med Biol Sci

View full text Add to dashboard Cite

show abstract

“…Entre las técnicas de laboratorio disponibles para el diagnóstico de esta enfermedad están el análisis histológico, que detecta hasta 88 % de los casos, la tinción de Ziehl-Neelsen sobre el tejido o el esputo, el cultivo de secreciones pertinentes y la búsqueda de ADN micobacteriano mediante la técnica de reacción en cadena de la polimerasa (PCR), la cual es muy útil en el diagnóstico rápido de esta entidad y de todas las formas de tuberculosis extrapulmonar y pulmonar paucibacilar (24,33,34).…”

Section: Discussionunclassified

Diagnóstico patológico y molecular de un caso de tuberculosis laríngea primaria en un médico

et al. 2013

View full text Add to dashboard Cite

Contribución de los autores:Guillermo Campos: realización de los procedimientos quirúrgicos, revisión del manuscrito. Diana Palacios, Johanna Álvarez y Margarita Baldión: realización del estudio histopatológico, revisión y comentario del manuscrito. Leonardo Jurado: revisión de la historia clínica y la literatura científica pertinente, interpretación de los análisis moleculares microbiológicos y redacción del manuscrito. La tuberculosis laríngea primaria es una enfermedad rara con una amplia gama de manifestaciones clínicas. Se reporta el caso de un médico otorrinolaringólogo con diabetes de tipo II y con diagnóstico de tuberculosis laríngea primaria. El diagnóstico de cáncer de cuerda vocal se había considerado en otra institución, y al ingreso el paciente sólo presentaba disfonía de seis meses de evolución. En el estudio histopatológico se encontraron granulomas, células gigantes multinucleadas, fibrosis y necrosis, y en la tinción de Ziehl-Neelsen, bacilos ácido-alcohol resistentes. El cultivo del tejido de cuerda vocal para micobacterias y la PCR-IS6110 fueron positivos. La cepa de Mycobacterium tuberculosis demostró sensibilidad a todos los medicamentos de primera línea. Se inició tratamiento según la estrategia DOTS (Directly Observed Treatment, Short-course). Se discute la presentación clínica, los diagnósticos diferenciales, el abordaje diagnóstico y los factores de riesgo asociados y se hace una breve revisión de la literatura.Palabras clave: Mycobacterium tuberculosis, reacción en cadena de la polimerasa, tuberculosis laríngea, granuloma, disfonía. doi: http://dx.doi.org/10.7705/biomedica.v34i1.1624 Pathological and molecular diagnosis in a case of primary laryngeal tuberculosis in a physicianPrimary laryngeal tuberculosis is a rare disease with a wide variety of clinical manifestations. We report the case of an ear-nose and throat diabetic physician with primary laryngeal tuberculosis. The diagnosis of laryngeal cancer had been considered before in another institution, and at the patient's admission, he only presented dysphonia with a six-month evolution. The vocal cord histological examination showed granulomas, giant cells, fibrosis and necrosis, and the Ziehl-Neelsen staining showed acid-alcohol resistant bacilli. The culture from vocal cord tissue was positive for mycobacteria, and IS6110-PCR was positive too. The Mycobacterium tuberculosis strain was sensitive to first line drugs. Treatment using directly observed therapy short-course (DOTS) was initiated. Clinical presentation, differential diagnosis, diagnostic workup, associated risk factors and a brief literature revision are discussed in this article.

show abstract

“…2 This is partly due to the occasional uncommon clinical presentations with involvement of atypical sites. The oral cavity accounts for 0.2 to 1.5% of all the cases of extrapulmonary tuberculosis and is mostly secondary to pulmonary tuberculosis.…”

Section: Commentsmentioning

confidence: 99%