Mycobacterial infections in coal workers’ pneumoconiosis patients in South Korea

Kim, Young Mi; Kim, Myungshin; Kim, Seong Keun; Park, Kyoungsil; Jin, Song-Hyo; Lee, Ui Sun; Kim, Yonggoo; Chae, Gue Tae; Lee, Seong Beom

doi:10.1080/00365540903089468

Cited by 20 publications

(10 citation statements)

References 22 publications

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“…51 Kim et al retrospectively examined 129 patients with coal workers pneumoconiosis in South Korea and found that 21 (16%) were also infected with NTM, with MAC accounting for about half of the isolates. 53…”

Section: Pneumoconiosismentioning

confidence: 99%

Underlying Host Risk Factors for Nontuberculous Mycobacterial Lung Disease

Chan

Iseman

2013

Semin Respir Crit Care Med

125

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Nontuberculous mycobacteria (NTM) are environmental microbes that cause a variety of human diseases, particularly chronic lung infections. Despite the fact that NTM are widespread in the environment, relatively few people develop NTM lung disease, suggesting intrinsic vulnerability in some individuals. This paper reviews the evidence that underlying disorders predispose to NTM lung disease, in particular primary conditions that result in bronchiectasis, chronic obstructive pulmonary disease, α-1-antitrypsin anomalies, pneumoconiosis, pulmonary alveolar proteinosis, and frank immunosuppressive states such as that associated with the use of anti-tumor necrosis factor-α biologics, posttransplantation immunosuppression, and HIV infection. Over the past several decades, NTM lung disease has been increasingly identified in postmenopausal women with slender body habitus. Thus we will also review the clinical and experimental evidence which supports the observation that such individuals are predisposed to NTM lung disease.

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Section: Pneumoconiosismentioning

confidence: 99%

Underlying Host Risk Factors for Nontuberculous Mycobacterial Lung Disease

Chan

Iseman

2013

Semin Respir Crit Care Med

125

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“…Epidemiological [6–8] and experimental studies [20,21] have shown an association between changes induced by these toxic particles and increased susceptibility to mycobacterial infection. Consistent with these results, we demonstrated that the risk of TB infection in these patients was higher than in the general population of Taiwan (473 vs 55 per 100,000 person-years, relative risk: 8.6) and continued to increase during the whole clinical course of occupational lung diseases (Fig.…”

Section: Discussionmentioning

confidence: 99%

“…[6–8] Moreover, other pulmonary disorders including chronic obstructive pulmonary disease (COPD) [9,10] and lung cancer [11–13] are also associated with these occupational lung diseases. Both COPD and lung cancer manifest as irreversible disease courses and further result in poor prognoses among these patients.…”

Section: Introductionmentioning

confidence: 99%

Prognostic effect of tuberculosis on patients with occupational lung diseases

Hung

Su²,

Ou³

2016

Medicine

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Occupational lung diseases are well recognized risk factors for tuberculosis (TB). However, little research investigated the effect of TB on the clinical course and outcome of occupational lung diseases.We conducted a 13-year observational study of a nationwide cohort to evaluate the risk and prognosis of TB among patients with occupational lung diseases in Taiwan.By using the Taiwan National Health Insurance database, occupational lung diseases cohort was identified according to diagnosis codes from 1998 to 2008 and prospectively monitored until the end of 2010, loss to follow-up, or death. Newly diagnosed TB, comorbidities, and demographic characteristics were evaluated as prognostic variables in the survival analysis of patients with occupational lung diseases using Cox proportional hazard regression models.A total of 12,787 study participants were enrolled with an average of 9.69 years of follow-up. Among them, 586 (4.58%) had newly diagnosed TB and 3180 (24.87%) died during follow-up. The incidence of TB was 473 per 100,000 person-years, and the risk of TB infection significantly increased over time. The independent risk factors for mortality included male gender (hazard ratio [HR]: 2.23, 95% confidence interval [CI]: 1.91–2.60), age (HR: 1.05, 95% CI: 1.05–1.06), TB (HR: 1.17, 95% CI: 1.01–1.37), congestive heart failure (HR: 1.44, 95% CI: 1.17–1.79), cerebrovascular disease (HR: 1.34, 95% CI: 1.15–1.57), chronic obstructive pulmonary disease (HR: 1.44, 95% CI: 1.33–1.56), and asthma (HR: 1.27, 95% CI: 1.15–1.40). In addition, patients with TB infections had worse outcomes in the survival analysis than those without TB (log-rank test P = 0.02).Despite the low prevalence of occupational lung diseases in Taiwan, patients with those diseases had a higher TB incidence than the general population did (473 vs 55 per 100,000 person-years). Furthermore, even with effective antimicrobial chemotherapy, TB infection was a prognostic factor leading to poor outcomes in the patients with occupational lung diseases. We recommend intensive medical surveillance of TB in these high-risk patients for better control of TB and improvement of occupational health in Taiwan.

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“…CWP patients often present complications with some other diseases, including tuberculosis, cancer or autoimmune diseases [ 20 , 26 ]. Tuberculosis was the most common complication [ 27 ]. The rate of CWP cases complicated with pulmonary tuberculosis was 7.27% in the coal mine, which was reduced by 8.55% compared with the proportion of 15.82% in 1986.…”

Section: Discussionmentioning

confidence: 99%

Prevalence Characteristics of Coal Workers’ Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China

Han

et al. 2015

IJERPH

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Coal Workers’ Pneumoconiosis (CWP) is the primary occupational disease in China. However, information about the definite prevalence of CWP is only partially available. The aims of our study were to assess the prevalence characteristics of CWP in a state-owned coal mine, evaluate the effects of control measures and develop further preventive strategies for CWP. The total study population included 495 cases who were diagnosed with CWP from the construction of this coal mine to the end of October 2014. Individuals’ information, including duration of dust exposure, job titles, age as first diagnosis, stages of CWP, CWP progress, complications with pulmonary tuberculosis, death and others were collected and analyzed. The results showed that 71.11% of 495 CWP cases were stage I and 90.71% were involved in tunneling or coal mining. The mean dust exposure period in CWP patients was 26.7 years, the mean latent period was 29.3 years and the mean diagnosed age was 50.3 years old. The proportion of CWP diagnosed after ending dust exposure were remarkably increased with the time passing. Among the CWP cases, 36 (7.27%) were complicated with pulmonary tuberculosis. The mortality of patients with stage III was the highest (60.71%) (p < 0.0001). Our data obviously show that more strict policies to protect coal miners are needed to be implemented in China, especially for tunneling and mining workers.

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Mycobacterial infections in coal workers’ pneumoconiosis patients in South Korea

Cited by 20 publications

References 22 publications

Underlying Host Risk Factors for Nontuberculous Mycobacterial Lung Disease

Underlying Host Risk Factors for Nontuberculous Mycobacterial Lung Disease

Prognostic effect of tuberculosis on patients with occupational lung diseases

Prevalence Characteristics of Coal Workers’ Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China

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