Mycobacterium arupense finger osteomyelitis: Case report

Jaime-Villalonga, Alejandro; Saul, Zane; Miljkovic, Goran

doi:10.1016/j.ijid.2020.01.027

Cited by 5 publications

(2 citation statements)

References 7 publications

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“…Almost all microorganisms, including viruses, bacteria, and fungi, can cause osteomyelitis. 1 Many pathogens such as Staphylococcus aureus , 2 Salmonella , 3 Candida , 4 non-tuberculous mycobacteria (NTM), 5 Cryptococcus , 6 Bartonella , 7 and Mycobacterium tuberculosis 8 have been reported to cause osteomyelitis. NTM have recently garnered increased research attention because they can cause infections in immunocompromised patients, in whom, the infection presents as a disseminated extrapulmonary form.…”

Section: Introductionmentioning

confidence: 99%

Refractory Osteomyelitis Caused by Mycobacterium aubagnense and Its L-Form: Case Report and Review of the Literature

Cheng¹,

Zhang²,

Huang³

et al. 2022

IDR

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Purpose To report a rare case of tibial osteomyelitis caused by Mycobacterium aubagnense and its L-form, to systematically review non-tuberculous mycobacteria (NTM) infections of the bones, and to summarize the medication guidelines for infections with NTM and its L-forms. Methods Case report and literature review. Results We report a 31-year-old HIV-positive man who developed osteomyelitis caused by M. aubagnense and its L-form. Culture, electron microscopy, polymerase chain reaction assay, and a reversion test confirmed the existence of M. aubagnense . The patient was treated with surgical debridement and a combination of systemic antibiotics, and continued to take antiretroviral treatment. Some clinical improvement was noted shortly after the initiation of this treatment. Resolution of osteomyelitis was achieved after 10 months. We also systematically reviewed cases of NTM osteomyelitis in the PubMed database and compared antibiotic sensitivity between L-forms and their prototype bacteria. We have summarized the treatment regimens for infections of the bone and bone marrow caused by NTM and their L-forms. Conclusion We have reported the first case of refractory osteomyelitis caused by M. aubagnense and its L-form in a patient with immune deficiency, reviewed the literature on NTM osteomyelitis, and compared the antibiotic sensitivity of L-forms and their prototype bacteria.

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Section: Introductionmentioning

confidence: 99%

Refractory Osteomyelitis Caused by Mycobacterium aubagnense and Its L-Form: Case Report and Review of the Literature

Cheng¹,

Zhang²,

Huang³

et al. 2022

IDR

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“…[1] In the literature, osteomyelitis of the phalanges caused by the Candida species (spp.) is rare and many culprits play a role in the development of osteomyelitis; [5,6] however, it is a difficult-to-treat condition with a high morbidity rate. Among Candida spp., Candida albicans is the most common cause of osteomyelitis.…”

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confidence: 99%

A rare cause of osteomyelitis of distal phalanx: Candida lusitaniae

Acar

Bezirgan

2021

Jt Dis Relat Surg

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Osteomyelitis of the phalanx caused by Candida species are rare. A 49-year-old female patient was admitted to an external center with a splinter injury of the third phalanx of the middle finger of her left hand about 45 days ago. She was referred to our clinic with persistent pain and discharge, despite four-week antibiotherapy. Debridement and curettage were performed and partial excision of the distal phalanx at an appropriate level was done. Her complaints gradually resolved postoperatively with prescribed antibiotics for the pathogen identified as Candida lusitaniae based on the intraoperative cultures. At her three-month follow-up visit, treatment yielded near-excellent results. To the best of our knowledge, this is the first case of osteomyelitis of the distal phalanx caused by Candida lusitaniae in the literature, highlighting the importance of definitive diagnosis and pathogen-specific treatment, rather than empirical treatment, to achieve favorable results with cure.

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