2014
DOI: 10.1128/cvi.00032-14
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Mycobacterium avium subsp. paratuberculosis Antibody Response, Fecal Shedding, and Antibody Cross-Reactivity to Mycobacterium bovis in M. avium subsp. paratuberculosis-Infected Cattle Herds Vaccinated against Johne's Disease

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Cited by 31 publications
(34 citation statements)
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“…Expected net direct benefits per animal per year were $8.02 for a herd with an initial 10% prevalence of MAP-shedding animals. The results also show that the effect of MAP vaccination on the overall prevalence and the prevalence of latent infected and low shedder animals is fairly small, whereas the effect on the number of heavy shedders and clinical animals is larger, which is consistent with earlier studies (Groenendaal and Galligan, 2003;Knust et al, 2013;Tewari et al, 2014).…”
supporting
confidence: 91%
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“…Expected net direct benefits per animal per year were $8.02 for a herd with an initial 10% prevalence of MAP-shedding animals. The results also show that the effect of MAP vaccination on the overall prevalence and the prevalence of latent infected and low shedder animals is fairly small, whereas the effect on the number of heavy shedders and clinical animals is larger, which is consistent with earlier studies (Groenendaal and Galligan, 2003;Knust et al, 2013;Tewari et al, 2014).…”
supporting
confidence: 91%
“…On the other hand, the analysis by Knust et al (2013) did not separate the effect of vaccination from the effect of management practices, which also help in limiting disease spread and contribute to the apparent effect of vaccination. In the study by Tewari et al (2014), MAP vaccination decreased the prevalence and shedding, even in a herd that implemented virtually no change in preventive practices, supporting the conclusion that vaccination by itself has an effect on prevalence and shedding, but prevalence may be further decreased by implementation of good management practices. Third, the disease-spread model developed by Zagmutt et al (2012) and used in this study was a Markov Chain model and thus assumed that infection probability did not decrease as the number of shedding animals decreased over time.…”
supporting
confidence: 52%
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“…For this purpose, we used the caprine model that was used previously (12,24,25). Unfortunately, it was difficult to identify a goat herd that was Johne's disease free for our study, which resulted in reducing the group size for the Mycopar vaccine, a well-studied vaccine (12,26,27). However, we were able to successfully identify significant differences between experimental groups, despite this limitation.…”
Section: Discussionmentioning
confidence: 99%
“…Studies have confirmed that vaccination not only reduces the prevalence of JD but also has economic benefits to farmers (Groenendaal et al, 2015). Killed vaccine is considered to be an effective tool for controlling the spread of disease (Tewari et al, 2014).The primary reason for using an adjuvant in the immunization of an experimental animal is to produce a high-titer, high-affinity, and high-avidity antibody for use in other experiments. Freund's incomplete adjuvant (FIA) is very efficient adjuvants in this regard (Lindblad, 2000).…”
Section: Introductionmentioning
confidence: 99%