Mycobacterium Haemophilum

Modi, Dimple; Pyatetsky, Dmitry; Edward, Deepak P.; Ulanski, Lawrence; Pursell, Kenneth; Tessler, Howard H.; Goldstein, Debra A.

doi:10.1097/iae.0b013e318030e622

Cited by 32 publications

(8 citation statements)

References 11 publications

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“…There were 44 cases of endophthalmitis reported in the literature [ 6 , 74 , 92 , 106 , 116 , 133 , 138 , 147 – 172 ]. Most were preceded by an intervention (28/37 eyes, 75.7%), mainly cataract surgery with IOL insertion (18/37 eyes, 48.6%).…”

Section: Results Specific To Location Of Infectionmentioning

confidence: 99%

Nontuberculous Mycobacterial Ocular Infections: A Systematic Review of the Literature

Kheir

Sheheitli

Fattah

et al. 2015

BioMed Research International

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Nontuberculous or atypical mycobacterial ocular infections have been increasing in prevalence over the past few decades. They are known to cause periocular, adnexal, ocular surface and intraocular infections and are often recalcitrant to medical therapy. These infections can potentially cause detrimental outcomes, in part due to a delay in diagnosis. We review 174 case reports and series on nontuberculous mycobacterial (NTM) ocular infections and discuss etiology, microbiology, risk factors, diagnosis, clinical presentation, and treatment of these infections. History of interventions, trauma, foreign bodies, implants, contact lenses, and steroids are linked to NTM ocular infections. Steroid use may prolong the duration of the infection and cause poorer visual outcomes. Early diagnosis and initiation of treatment with multiple antibiotics are necessary to achieve the best visual outcome.

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Section: Results Specific To Location Of Infectionmentioning

confidence: 99%

Nontuberculous Mycobacterial Ocular Infections: A Systematic Review of the Literature

Kheir

Sheheitli

Fattah

et al. 2015

BioMed Research International

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“…To date, only three cases of M. haemophilum ocular infection have been published in previously reported literature [ 3 , 10 – 12 ]. The common features were cutaneous lesions and an incomplete or impaired immune function, including young age, immunosuppressed, or uncontrolled diabetes.…”

Section: Discussionmentioning

confidence: 99%

“…The common features were cutaneous lesions and an incomplete or impaired immune function, including young age, immunosuppressed, or uncontrolled diabetes. Cutaneous lesions were early, and were the common signs of M. haemophilum infection in all of the reported cases of ocular infection [ 3 , 8 , 10 – 12 ]. Therefore, ocular involvement appeared to be secondary to hematogenous spread.…”

Section: Discussionmentioning

confidence: 99%

“…Zuercher et al reported a case of healthy child who presented with fistulous dacryocystitis and multiple cervical lymphadenopathies [ 11 ]. The only intraocular M. haemophilum infection was reported by Modi et al in 2007; the authors described a case of chronic endogenous endophthalmitis with multiple skin nodules in a patient who was receiving immunosuppressive drugs after cardiac transplantation [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Late-onset postoperative Mycobacterium haemophilum endophthalmitis masquerading as inflammatory uveitis: a case report

et al. 2018

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BackgroundAlthough atypical mycobacteria had been increasingly found in various ocular infections in the past decades, a slow-growing Mycobacterium haemophilum (M. haemophilum) was scarcely reported. Similar to tuberculous infection, the presentation can masquerade as low-grade granulomatous intraocular inflammation with partial response to corticosteroids. Besides, the special requirements for culture make this pathogen difficult to diagnose. The study aims to report the clinical presentation and notify the awareness of NTM endophthalmitis among clinicians. This is the first case report of late-onset, postoperative M. haemophilum endophthalmitis in the literature.Case presentationA 66-year-old man with non-insulin-dependent diabetes mellitus (NIDDM) manifested chronic granulomatous inflammation in the left eye after multiple glaucoma surgeries. With a diagnosis of noninfectious panuveitis, he was treated with systemic corticosteroids. The inflammation initially responded to therapy although it subsequently worsened and became purulent endophthalmitis. The vitreous cultures grew M. haemophilum. Intraocular and systemic antimicrobial treatments were administered early, but the patient eventually turned blind.ConclusionsM. haemophilum endophthalmitis is a rare but serious intraocular complication leading to loss of vision or eyeball. Awareness of atypical mycobacterial infections is necessary especially in patients with impaired immune function, previous intraocular surgery, and corticosteroid resistance. Proper laboratory investigations and treatments should be performed. However, due to the rarity of the disease, the development of guidelines for its investigation and therapy is still challenging.

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“…The most recent review was done by Lindeboom et al in 2011 [2]. The adult infections most frequently involve the skin, but there are a number of case reports with septic arthritis [3], disseminated [4] and pulmonary infections [5], pyomyositis [6], osteomyelitis [7], and ophthalmic involvement [8, 9]. Rarely, the involvement of other systems has been reported.…”

Section: Discussionmentioning

confidence: 99%