2006
DOI: 10.1097/01.tp.0000225760.09969.1f
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Mycophenolate Mofetil Dose Reductions and Discontinuations after Gastrointestinal Complications Are Associated with Renal Transplant Graft Failure

Abstract: Renal transplant recipients who underwent MMF dose reduction or withdrawal following GI diagnosis are associated with increased risk of graft failure.

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Cited by 145 publications
(116 citation statements)
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“…Diarrhea may also be due to drug toxicity not related to immunosuppressive therapy, such as oral hypoglycemic agents, inflammatory bowel disease exacerbation, broad-spectrum antibiotics, or, lastly, infections (6). In practice, negative microbiological diagnosis leads nephrologists to perform invasive complementary tests like colonoscopy and often to modify immunosuppressive treatment considered to be the cause of diarrhea, with a risk of acute or chronic transplant rejection (9)(10)(11). Yet in various studies, it has been reported that, in 38 to 64% of cases, diarrhea was of infectious origin (1,(12)(13)(14).…”
mentioning
confidence: 99%
“…Diarrhea may also be due to drug toxicity not related to immunosuppressive therapy, such as oral hypoglycemic agents, inflammatory bowel disease exacerbation, broad-spectrum antibiotics, or, lastly, infections (6). In practice, negative microbiological diagnosis leads nephrologists to perform invasive complementary tests like colonoscopy and often to modify immunosuppressive treatment considered to be the cause of diarrhea, with a risk of acute or chronic transplant rejection (9)(10)(11). Yet in various studies, it has been reported that, in 38 to 64% of cases, diarrhea was of infectious origin (1,(12)(13)(14).…”
mentioning
confidence: 99%
“…Some evidence suggests that MMF dose modification, either reduction or discontinuation, may increase rejection rate and graft loss. However, studies investigating this relationship are mainly related to renal transplants [18][19][20] , while data from cardiac transplant registries are scarce [21][22] . Knoll et al 18 found that the cumulative number of days on reduced MMF dose increased significantly the risk of acute graft rejection.…”
Section: Discussionmentioning
confidence: 99%
“…Another report from USRDS data of 3675 patients with gastrointestinal complications under MMF and subsequent dose reduction also disclosed an increased risk for graft loss after dose reduction or discontinuation of MMF (54).…”
Section: Mpa-pharmacokinetics and Gastro-intestinal Side Effectsmentioning
confidence: 99%