Mycoplasma bovis isolates recovered from cattle and bison (Bison bison) show differential in vitro effects on PBMC proliferation, alveolar macrophage apoptosis and invasion of epithelial and immune cells

Suleman, Muhammad; Prysliak, Tracy; Clarke, Kyle; Burrage, Pat; Windeyer, Claire; Perez-Casal, José

doi:10.1016/j.vetmic.2016.02.016

Cited by 36 publications

(45 citation statements)

References 32 publications

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“…The invasion of circulating immune cells and erythrocytes should not only play an important role in pathogenicity, potentially protecting the pathogen from the host immune response and administered antimicrobials, but could also promote persistence and further dissemination of the pathogen between organ systems. M. bovis antigens have also been visualized in hepatocytes and epithelial cells (Maeda et al., ), and invasion followed by intracellular replication has been demonstrated in primary embryonic calf turbinate cells (Bürki, Gaschen et al., ), as well as in bovine embryonic tracheal epithelial cells (Suleman et al., ). Although much awaits to be discerned about the pathways for entry and survival in these privileged niches, recent advances in molecular tools and imaging techniques should expedite our understanding of these processes.…”

Section: The Causative Organismmentioning

confidence: 99%

Gap analysis ofMycoplasma bovisdisease, diagnosis and control: An aid to identify future development requirements

Calcutt

Lysnyansky

Sachse

et al. 2018

Transbound Emerg Dis

103

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There is a worldwide problem of disease caused by Mycoplasma (M.) bovis in cattle; it has a significant detrimental economic and animal welfare impact on cattle rearing. Infection can manifest as a plethora of clinical signs including mastitis, pneumonia, arthritis, keratoconjunctivitis, otitis media and genital disorders that may result in infertility and abortion. Current diagnosis and control information are reviewed and analysed to identify gaps in knowledge of the causative organism in respect of the disease pathology, diagnosis and control methods. The main considerations are as follows: no vaccines are commercially available; antimicrobial resistance is increasing; diagnostic and antimicrobial sensitivity testing needs to be improved; and a pen-side test would facilitate more rapid diagnosis and implementation of treatment with antimicrobials. More data on host susceptibility, stress factors, immune response and infectious dose levels are required. The impact of asymptomatic carriers, M. bovis survival in the environment and the role of wildlife in transmitting the disease also needs investigation. To facilitate development of vaccines, further analysis of more M. bovis genomes, its pathogenic mechanisms, including variable surface proteins, is required, along with reproducible disease models.

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Section: The Causative Organismmentioning

confidence: 99%

Gap analysis ofMycoplasma bovisdisease, diagnosis and control: An aid to identify future development requirements

Calcutt

Lysnyansky

Sachse

et al. 2018

Transbound Emerg Dis

103

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“…The ability of M. bovis to invade and persist intracellularly, suggests that balanced Th-1/Th-2 response may be a better choice [70,71]. Numerous research groups have focused recently on studying the interaction of M. bovis and its bovine host [13,[18][19][20][21][23][24][25][26][27]. A strong push from the industry is needed to encourage funding organizations to invest more in such studies, as they are important for the understanding of how M. bovis modulates the host immune system.…”

Section: Discussionmentioning

confidence: 99%

“…Activation of CD4+, CD8+ and c/d T-cells has been observed in response to heat-killed M. bovis [11], but not to live bacterial cells [13][14][15][16][17]. Although M. bovis is predominantly an extracellular pathogen, there is in vivo and in vitro evidence that suggests the potential for the bacterium to enter host cells [18][19][20][21][22]. Intracellular M. bovis can survive inside cells [13,20,21]; modulate cytokine expression [13,[23][24][25][26] and apoptosis [13,20,27]; or directly play a role in pathogenesis [28].…”

Section: The Challengesmentioning

confidence: 99%

“…Although M. bovis is predominantly an extracellular pathogen, there is in vivo and in vitro evidence that suggests the potential for the bacterium to enter host cells [18][19][20][21][22]. Intracellular M. bovis can survive inside cells [13,20,21]; modulate cytokine expression [13,[23][24][25][26] and apoptosis [13,20,27]; or directly play a role in pathogenesis [28]. Thus, because of the extra-and intracellular presence of M. bovis we believe that a vaccine that equally induces Th-1 and Th-2 responses would be more advantageous.…”

Section: The Challengesmentioning

confidence: 99%

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Status of the development of a vaccine against Mycoplasma bovis

Perez-Casal¹,

Prysliak²,

Maina³

et al. 2017

Vaccine

Self Cite

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“…Three positive results obtained in this study in the CapriLAT test proved to be negative by immunoblotting. Bison can be infected with M. bovis (18). Previously, six sera with specific antibodies to M. bovis were found in European bison (Bison bonasus) which came from Eastern Poland and had gross lung lesions typical of M. bovis infection (6).…”

Section: Discussionmentioning

confidence: 99%

Screening of the Cervidae family in Poland for Mycoplasma species

Dudek

Bednarek

Szacawa

et al. 2016

Journal of Veterinary Research

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Introduction: Several Mycoplasma species can cause severe diseases in ruminant hosts, some of which are the diseases listed by the World Organisation for Animal Health (OIE). The role of the Cervidae family in carrying and transmitting ruminant mycoplasma infections in Poland is unknown. Material and Methods: Antibody and antigen detection tests for the main mycoplasma species that can affect wild ruminants were performed on 237 samples (serum, nasal swab, bronchoalveolar lavage, and lung) collected from 161 animals during 2011-2014. The samples were obtained from a cull of healthy population of deer which included: 96 red deer (Cervus elaphus elaphus), 19 fallow deer (Dama dama), and 46 roe deer (Capreolus capreolus). Results: Serological screening tests revealed positive reactions to Mycoplasma bovis in one sample and to Mycoplasma capricolum subsp. capripneumoniae in three samples; however, these three samples were negative by immunoblotting. Other antibody and antigen detection tests demonstrated negative results. Conclusion: Currently wild cervids in Poland do not play a significant role in transmitting mycoplasma infections to domestic animals, but they remain a potential risk.

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Mycoplasma bovis isolates recovered from cattle and bison (Bison bison) show differential in vitro effects on PBMC proliferation, alveolar macrophage apoptosis and invasion of epithelial and immune cells

Cited by 36 publications

References 32 publications

Gap analysis ofMycoplasma bovisdisease, diagnosis and control: An aid to identify future development requirements

Gap analysis ofMycoplasma bovisdisease, diagnosis and control: An aid to identify future development requirements

Status of the development of a vaccine against Mycoplasma bovis

Screening of the Cervidae family in Poland for Mycoplasma species

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