Mycoplasma infections as models of chronic joint inflammation

Cole, Barry C.; Cassell, Gail H.

doi:10.1002/art.1780221209

Cited by 55 publications

(16 citation statements)

References 41 publications

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“…hovis invites comparison of this disease with rheumatoid arthritis, a comparison that has been made with other mycoplasmal arthritides [ 5 ] . Further investigation into mechanisms of pathogenicity in M .…”

Section: Discussionmentioning

confidence: 99%

Morphologic Changes Following Intraarticular Inoculation ofMycoplasma bovisin Calves

et al. 1983

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Abstract. Intraarticular inoculation of M~up/u.smu hovis into the joints of six-week-old calves caused severe arthritis in five inoculates and mild arthritis in a sixth. Intraarticular inoculation of killed M. hovis did not cause arthritis.Arthritic calves had fever. joint swelling. lameness. neutrophilia, and intercurnent pneumonia from which M. hovis could not be recovered.Gross lesions were massive fibrinosuppurative synovitis and tenosynovitis, erosion of cartilage, and its replacement by polypoid granulation tissue. Histologic lesions were extensive ulceration of synovial membranes. leukocytic infiltration of the subsynovium, congestion, hyperemia, and thrombosis of the subsynovial vessels. Cartilage erosion was accompanied by chronic osteomyelitis and formation of pannus tissue. The presence of thrombi and platelet aggregates suggests that the inflammatory process in the synovium may arise from the interaction of M . hovis with the vasculature and the coagulation process of the host.

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Section: Discussionmentioning

confidence: 99%

Morphologic Changes Following Intraarticular Inoculation ofMycoplasma bovisin Calves

et al. 1983

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“…V RARIOUS ETIOLOGIC AGENTS INcluding viruses (1,2), bacteria (3)(4)(5), and mycoplasmas (6) have been suggested as causes of rheumatoid arthritis in humans. However, so far no convincing evidence has been presented for a role of these agents in the disease.…”

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confidence: 99%

Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I

Iwakura¹,

Tosu²,

Yoshida³

et al. 1991

Science

332

149

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Human T cell leukemia virus type-I (HTLV-I) is the etiologic agent of adult T cell leukemia and has also been suggested to be involved in other diseases such as chronic arthritis or myelopathy. To elucidate pathological roles of the virus in disease, transgenic mice were produced that carry the HTLV-I genome. At 2 to 3 months of age, many of the mice developed chronic arthritis resembling rheumatoid arthritis. Synovial and periarticular inflammation with articular erosion caused by invasion of granulation tissues were marked. These observations suggest a possibility that HTLV-I is one of the etiologic agents of chronic arthritis in humans.

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“…This mycoplasma has been detected in blood of patients with rheumatoid arthritis, producing systemic mycoplasmal infections [14], these results suggest that M. fermentans may play a role in the development of the disease. Some mycoplasmas may act as unspecific mitogens of B and T cells, while other mycoplasma ( M. arthritidis ) produce MAM, which shows superantigenic activity [5,15]. M. fermentans possesses a potent immunomodulator product named macrophage activating lipopeptide 2 (MALP-2) which activates macrophages to release cytokines which may in turn increase the neutrophilic infiltrate into the joint.…”

Section: Introductionmentioning

confidence: 99%

Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

Rivera

Yáñez

León-Tello

et al. 2002

BMC Musculoskelet Disord

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Background: Mycoplasma fermentans has been associated with rheumatoid arthritis. Recently, it was detected in the joints and blood of patients with rheumatoid arthritis, but it is not clear yet how the bacteria enter the body and reach the joints. The purpose of this study was to determine the ability of M. fermentans to induce experimental arthritis in rabbits following inoculation of the bacteria in the trachea and knee joints.

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Mycoplasma infections as models of chronic joint inflammation

Cited by 55 publications

References 41 publications

Morphologic Changes Following Intraarticular Inoculation ofMycoplasma bovisin Calves

Morphologic Changes Following Intraarticular Inoculation ofMycoplasma bovisin Calves

Induction of Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Mice Transgenic for HTLV-I

Experimental arthritis induced by a clinical Mycoplasma fermentans isolate

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