Mycoplasmas and "non-specific" genital infection. I. Previous studies and laboratory aspects.

Taylor‐Robinson, David; Addey, J. P.; Hare, M. J.; Dunlop, E. M. C.

doi:10.1136/sti.45.4.265

Cited by 14 publications

(4 citation statements)

References 56 publications

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“…A causal association of M. hominis with infections in the lower genital tract of females is, however, still uncertain, although many attempts have been made to evaluate its role in such conditions (Taylor-Robinson, Addey, Hare, and Dunlop, 1969). That M. hominis may play a role in infections of the upper genital tract of the female has been proposed by Melen and Gotthardson (1955), Stokes (1955), and Lemcke and Csonka (1962).…”

mentioning

confidence: 99%

Antibodies to Mycoplasma hominis in patients with genital infections and in healthy controls.

Mårdh¹,

Weström²

1970

Sexually Transmitted Infections

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mentioning

confidence: 99%

Antibodies to Mycoplasma hominis in patients with genital infections and in healthy controls.

Mårdh¹,

Weström²

1970

Sexually Transmitted Infections

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“…T-mycoplasmas as a possible cause of non-gonococcal urethritis in the male has been discussed in numerous com-munications, but their role, if any in this condition, is not clear (Taylor-Robinson, Addey, Hare & Dunlop, 1969;McCormack, Braun, Lee, Klein & Kass, 1973). We found no significant difference in the incidence of T-mycoplasmas between the patients and the controls.…”

Section: Uro-genital Tract Infections 13mentioning

confidence: 97%

Search for Urogenital Tract Infections in Patients with Symptoms of Prostatitis: Studies on Aerobic and Strictly Anaerobic Bacteria, Mycoplasmas, Fungi, Trichomonads and Viruses

Mårdh

Colleen

1975

Scandinavian Journal of Urology and Nephrology

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Seventy-nine patients with symptoms of nonacute prostatitis and 20 healthy volunteers were examined for uro-genital tract infection with bacteria, mycoplasmas, fungi, trichomonads and viruses. No differences in the results of the bacterial cultures were found between the patients and the controls. In only a few cases were established urinary tract pathogens found, but in no instance were these findings reproducible in later specimens. The cultures of the expressed prostatic fluids and the samples of semen gave no information of the occurrence of bacteria over and above that obtainable from examination of the urethral specimens. Significant bacteriuria was not found in any of the patients. Though Neisseria gonorrhoeae could not be isolated from any of the subjects, immunofluorescent studies revealed such organisms in seminal fluid in 8% of the patients. Nine of the patients had 1 to 3 years been considered successfully treated for gonorrhoea. Five of these nine patients were still found to harbour gonococci, as judged from the immunofluorescent studies. Corynebacterium vaginale was recovered in an equally low frequency (5%) from the patients and the volunteers. There was no significant difference in the incidence of T-mycoplasmas between the patients (46%) and the controls (35%), while Mycoplasma hominis was only found in the patients (10%). Trichomonas vaginalis could not be detected in wet smears of expressed prostatic fluid in any of the subjects, but could be cultured from one such specimen. Metacycline treatment (performed according the double blind cross-over technique) was studied for effects on the bacterial flora. In about 10% of the patients, an earlier not observed relative dominance of gram-negative rods was found on the cultures made after the therapy. Candida albicans was only isolated from the patients. It was found more often after (24%) than before the (15%) treatment. Complement-fixing antibodies to N. gonorrhoeae, cytomegalovirus and Chlamydia were found in 10, 19, and 33% of the patients, respectively. The corresponding figures for the healthy males were 0, 20 and 5%.

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“…Further work has both substantiated and failed to verify the earlier results. Those who consider it to be a commensal only include Freundt (1956), Black andRasmussen (1968), Taylor-Robinson, Addey, Hare, andDunlop (1969), and Gregory and Cundy (1970).…”

mentioning

confidence: 99%

Non-specific urethritis and the tetracyclines.

Grimble¹,

Amarasuriya²

1975

Sexually Transmitted Infections

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Non-specific urethritis (NSU) is treated as an entity, yet it includes cases of urethral inflammation presumed to be related to the presence of probably several specific organisms. The effectiveness of the tetracycline group of antibiotics in comparison with other forms of treatment is not in doubt (Wilcox, 1972). In the present study we wish to remark upon the aetiology of NSU and to discover whether tetracycline treatment can assist us in understanding the nature of NSU, and also to comment on the best application of tetracycline therapy.NSU Sompolinsky, Harari, Solomon, Caspi, Krakowski, and Henig, 1973;Wentworth, Bonin, Holmes, Gutman, Wiesner, and Alexander, 1973). Yet the role of this agent, although probably at times a pathogen, is still questionable (Richmond, Hilton, and Clarke, 1972;Hilton, Richmond, Milne, Hindley, and Clarke, 1974;Oriel, Powis, Reeve, Miller, and Nicol, 1974).It may be that Chlamydia agent plays an 'opportunist' role, and acts both as pathogen and as 'potential pathogen' in the genito-urinary tract. Much of this work is relatively new and still continuing. A recent study on the presence of antibodies to Chlamydia in patients with urethritis, and in persons without urethritis, does not make the position any clearer (Reeve, Gerloff, Casper, Philip, Oriel, and Powis, 1974). Mycoplasma hominis (and to a much lesser extent M. fermentans and M. salivarius) and T-strain mycoplasma can be present in those with a healthy genito-urinary epithelium as well as in those in whom the epithelium is inflamed. It would appear from the evidence that the T-strain may be present in over 60 per cent. of cases of urethritis, and M. hominis in about 20 per cent. of cases.

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Mycoplasmas and "non-specific" genital infection. I. Previous studies and laboratory aspects.

Cited by 14 publications

References 56 publications

Antibodies to Mycoplasma hominis in patients with genital infections and in healthy controls.

Antibodies to Mycoplasma hominis in patients with genital infections and in healthy controls.

Search for Urogenital Tract Infections in Patients with Symptoms of Prostatitis: Studies on Aerobic and Strictly Anaerobic Bacteria, Mycoplasmas, Fungi, Trichomonads and Viruses

Non-specific urethritis and the tetracyclines.

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