Mycosis fungoides in children and adolescents

Peters, Margot S.; Thibodeau, Stephen N.; White, John W.; Winkelmann, R. K.

doi:10.1016/0190-9622(90)70143-6

Cited by 97 publications

(79 citation statements)

References 26 publications

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“…In addition, two further patients developed Hodgkin disease. 6,8,9 In the current study, five patients developed progressive disease beyond Stage I. One presented initially with poikiloderma, and had associated lymphomatoid papulosis, one with follicular mucinosis, and three with the classic patches and plaques of MF.…”

Section: Prognosismentioning

confidence: 53%

“…23 CD8-positive MF has been reported to be more aggressive than CD4-positive disease, but this may reflect a failure to distinguish CD8-positive MF from other types of primary CTCLs. 6,[23][24][25] In a previous study, we found that CD8-positive CTCL patients with juvenile-onset MF appeared to behave in a similar manner to patients with CD4-positive juvenile-onset MF. 22 It has been reported that CD8-positive MF follows a more aggressive course if the neoplastic cells are CD2-negative and CD7-positive.…”

Section: Immunophenotypementioning

confidence: 99%

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Outcome in 34 patients with juvenile‐onset mycosis fungoides

Wain

Orchard

Whittaker

et al. 2003

Cancer

137

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New methodology for the stereoselective synthesis of trisubstituted olefins is presented. The use of ortho‐diphenylphosphanyl benzoate (o‐DPPB) as a directing leaving group for copper‐mediated allylic substitution with Grignard reagents allowed for the stereoselective construction of a wide range of E olefins, without the need for an adjacent electron‐withdrawing group. Our modular three‐step approach toward trisubstituted alkenes commenced with geminal α‐methylene aldehydes. Addition of an organometallic reagent and introduction of the o‐DPPB group by esterification was followed by the o‐DPPB‐directed copper‐mediated allylic substitution with a Grignard reagent to furnish stereodefined trisubstituted olefins. Additionally, incorporation of a stereocenter from the chiral pool allowed the preparation of an enantiomerically pure olefin that bore three alkyl substituents in high E/Z selectivity.

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Section: Prognosismentioning

confidence: 53%

Section: Immunophenotypementioning

confidence: 99%

Outcome in 34 patients with juvenile‐onset mycosis fungoides

Wain

Orchard

Whittaker

et al. 2003

Cancer

137

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“…Moreover, although mycosis fungoides is predominantly a disease of elderly patients, several cases have been reported in children, with or without FM. [48][49][50][51][52] Thus, it is not possible to exclude a diagnosis of mycosis fungoides solely on the basis of the age of the patient.…”

Section: Commentmentioning

confidence: 99%

Follicular Mucinosis

Cerroni¹,

Fink‐Puches²,

Bäck³

et al. 2002

Arch Dermatol

189

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Context: Beginning in 1957, patients have been described with localized alopecia characterized histopathologically by mucin deposition within hair follicles (follicular mucinosis [FM]). At least 2 distinct diagnostic entities have been proposed: one occurring in children and young adults without association with other diseases ("idiopathic" FM), the other occurring in elderly patients and associated with mycosis fungoides or Sézary syndrome ("lymphoma-associated" FM).Objective: To determine whether idiopathic and lymphoma-associated FM are distinct or related entities.

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“…In contrast to conventional mycosis fungoides, in which the neoplastic cells are CD4 þ in the vast majority of cases, 5 the neoplastic cells in hypopigmented mycosis fungoides have a CD8 þ T-cell phenotype. [6][7][8][9] The mechanism of hypomelanosis in hypopigmented mycosis fungoides is as yet unclear. Damaged melanosomes 10 and a decreased number of melanocytes 11,12 have been reported in hypopigmented mycosis fungoides lesions.…”

mentioning

confidence: 99%

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

et al. 2006

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Hypopigmented mycosis fungoides is an uncommon clinical variant of cutaneous T-cell lymphoma. We hypothesized that hypomelanosis in hypopigmented mycosis fungoides may have a similar mechanism as in vitiligo, a condition in which it is believed that alterations in expression of CD117 (stem cell factor receptor/KIT protein) on epidermal melanocytes and abnormal interactions between melanocytes and surrounding keratinocytes may play a pathogenic role. To test the hypothesis that similar mechanisms might also explain hypopigmentation in hypopigmented mycosis fungoides, skin specimens from five cases each of hypopigmented mycosis fungoides and vitiligo were studied immunohistochemically for immunophenotype of the infiltrating cells, CD117 (expressed by epidermal melanocytes), and pan melanoma cocktail of antigens (gp100, tyrosinase, and MART-1) expression; cases of conventional mycosis fungoides and normal skin were studied in parallel as controls. Our findings confirm a predominance of CD8 þ neoplastic T cells in hypopigmented mycosis fungoides. Similarly, the epidermal lymphocytic infiltrate in vitiligo was also composed of CD8 þ cytotoxic T cells, in contrast to an epidermal infiltrate composed of CD4 þ T cells in conventional mycosis fungoides. The average number of epidermal CD117 expressing cells followed the same pattern of decreased expression in hypopigmented mycosis fungoides as in vitiligo, whereas the levels in conventional mycosis fungoides were higher, and similar to that observed in normal skin. Furthermore, a decreased number of melanocytes per high-power field of the length of the biopsy was present in hypopigmented mycosis fungoides and vitiligo, as compared with either conventional mycosis fungoides or normal skin, suggesting a correlation between decreased expression of CD117 and decreased number of melanocytes. We propose that decreased expression of CD117 and its downstream events in melanocytes may be initiated by cytotoxic effects of melanosomal-antigen-specific CD8 þ neoplastic T lymphocytes, resulting in destabilization of CD117 and leading to dysfunction and/or loss of melanocytes in the epidermis of hypopigmented mycosis fungoides.

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Mycosis fungoides in children and adolescents

Cited by 97 publications

References 26 publications

Outcome in 34 patients with juvenile‐onset mycosis fungoides

Outcome in 34 patients with juvenile‐onset mycosis fungoides

Follicular Mucinosis

Decreased CD117 expression in hypopigmented mycosis fungoides correlates with hypomelanosis: lessons learned from vitiligo

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