Mycosis Fungoides in the Pediatric Population: Report from an International Childhood Registry of Cutaneous Lymphoma

Pope, Elena; Weitzman, Sheila; Ngan, Bo; Walsh, Scott; Morel, Kimberly D.; Williams, Judith V.; Stein, Sarah L.; Garzon, María C.; Knobler, Elizabeth; Lieber, Colette D.; Turchan, Kirsten; Wargon, Orli; Tsuchiya, Arline

doi:10.2310/7750.2009.08091

Cited by 86 publications

(106 citation statements)

References 21 publications

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“…Unlike conventional MF, a disease typical of the fifth to sixth decades of life, HMF affects a younger population, even children [2,4,7,8,9,10]. Our data confirm the relatively young age at onset.…”

Section: Discussionsupporting

confidence: 76%

Hypopigmented Mycosis Fungoides versus Mycosis Fungoides with Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?

et al. 2014

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Background: Hypopigmented mycosis fungoides (HMF) is a rare subtype of mycosis fungoides (MF). We compared patients with exclusive hypopigmented lesions with a group of MF patients with concomitant different lesions. Methods: 20 patients with HMF only and 14 patients with hypopigmented lesions concomitant with other types of lesions (mixed MF, MMF) were selected. Clinical-epidemiological analysis as well as histological and immunohistochemical studies were performed. Results: HMF and MMF preserve some similarities, like predilection for dark-skinned persons and slow progression, but they also present differences: the exclusive variant is associated with early onset and a clear CD8+ immunophenotype, whereas MMF patients tend to present a predominance of CD4+ cell infiltrates. Histological analysis revealed similar findings; relapsing courses were common. Conclusion: Whether patients are suffering from exclusive HMF or MMF, the presence of hypopigmented lesions can be considered a marker of good prognosis in MF, since both groups presented similar data, such as staging and disease duration.

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Section: Discussionsupporting

confidence: 76%

Hypopigmented Mycosis Fungoides versus Mycosis Fungoides with Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?

et al. 2014

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“…Cutaneous T-cell lymphoma (CTCL) onset before the age of 50 is rare, but an increasing incidence in the pediatric population has been reported over the past 10 years [60]. The early stages of CTCL present as slowly-progressing scaly patches/plaques (mycosis fungoides) or quickly-progressing generalized erythema (Sézary syndrome) on the trunk.…”

Section: Malignanciesmentioning

confidence: 99%

Diagnosis of Atopic Dermatitis: Mimics, Overlaps, and Complications

Siegfried

Hebert

2015

JCM

104

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Atopic dermatitis (AD) is one of the most common skin diseases affecting infants and children. A smaller subset of adults has persistent or new-onset AD. AD is characterized by pruritus, erythema, induration, and scale, but these features are also typical of several other conditions that can mimic, coexist with, or complicate AD. These include inflammatory skin conditions, infections, infestations, malignancies, genetic disorders, immunodeficiency disorders, nutritional disorders, graft-versus-host disease, and drug eruptions. Familiarity of the spectrum of these diseases and their distinguishing features is critical for correct and timely diagnosis and optimal treatment.

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“…The incidence of cutaneous T-cell lymphomas (CTCL) has been increasing and is currently 6.4 per million persons, based on Surveillance, Epidemiology, and End Results (SEER) registry data, with the highest incidence rates being reported among males (male:female incidence rate ratio 1.9) and AfricanAmericans (incidence rate ratio 1.5) [3]. While CTCL may occur in children and young adults, this is very uncommon and often associated with histologic variants of MF [5][6][7]. The incidence of CTCL increases significantly with age, with a median age at diagnosis in the mid-50s and a fourfold increase in incidence appreciated in patients over 70 [3,7].…”

Section: Disease Overviewmentioning

confidence: 99%

Cutaneous T‐cell lymphoma: 2011 update on diagnosis, risk‐stratification, and management

Wilcox

2011

American J Hematol

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Disease overview: Cutaneous T‐cell lymphomas are a heterogenous group of T‐cell lymphoproliferative disorders involving the skin, the majority of which may be classified as Mycosis fungoides (MF) or Sézary syndrome (SS).Diagnosis: The diagnosis of MF or SS requires the integration of clinical and histopathologic data.Risk‐adapted therapy: Tumor, node, metastasis, and blood (TNMB) staging remains the most important prognostic factor in MF/SS and forms the basis for a “risk‐adapted,” multidisciplinary approach to treatment. For patients with disease limited to the skin, expectant management or skin‐directed therapies is preferred, as both disease‐specific and overall survival for these patients is favorable. In contrast, patients with advanced‐stage disease with significant nodal, visceral, or blood involvement are generally approached with biologic‐response modifiers, denileukin diftitox, and histone deacetylase inhibitors before escalating therapy to include systemic, single‐agent chemotherapy. Multiagent chemotherapy may be used for those patients with extensive visceral involvement requiring rapid disease control. In highly‐selected patients with disease refractory to standard treatments, allogeneic stem‐cell transplantation may be considered. Am. J. Hematol., 2011. © 2011 Wiley‐Liss, Inc.

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Mycosis Fungoides in the Pediatric Population: Report from an International Childhood Registry of Cutaneous Lymphoma

Cited by 86 publications

References 21 publications

Hypopigmented Mycosis Fungoides versus Mycosis Fungoides with Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?

Hypopigmented Mycosis Fungoides versus Mycosis Fungoides with Concomitant Hypopigmented Lesions: Same Disease or Different Variants of Mycosis Fungoides?

Diagnosis of Atopic Dermatitis: Mimics, Overlaps, and Complications

Cutaneous T‐cell lymphoma: 2011 update on diagnosis, risk‐stratification, and management

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