Mydriatic Effect of Phenylephrine Hydrochloride

Haddad, Nickie J.; Moyer, Norma J.; Riley, Fenwick C.

doi:10.1016/0002-9394(70)90490-3

Cited by 60 publications

(26 citation statements)

References 9 publications

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“…The same amount of 2.5% solution was also tested. Phenylephrine, which after multiple application into the eye in the studies of Haddad et al [1970] and Smith et al [1976] produced in all age groups an equal myd riasis when used in 2.5 and 10% concentrations, proved in our study insufficient in the younger age groups in both concentrations. On the contrary, in the elderly a useful mydriasis for diagnostic purposes was obtained generally after 45 min.…”

Section: Discussionsupporting

confidence: 61%

Mydriatic Effect of Low Dose Phenylephrine

Salminen¹,

Aaltonen²,

Jäntti³

1980

Ophthalmic Res

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The mydriatic effect of one drop (40 μl) of 2.5 and 10% phenylephrine was studied in human eyes. The persons represented ages from 11 to 76 years. Pupillary diameter was registered by a measuring eye-piece mounted on a slit lamp under standardized lighting conditions used for the examination of the anterior parts of the eye. One application of phenylephrine in a concentration of 2.5 or 10% only occasionally caused mydriasis sufficient for diagnostic purposes under the age of 60. On the contrary, in persons over the age of 60 useful mydriasis was obtained by the same dose. In persons over 60 the stronger solution increased slightly the rate, but not the magnitude of mydriasis, which with the weaker solution was about 5.5 mm within 45 min. The age-related difference in mydriatic capacity of a single application of 2.5 and 10% phenylephrine is supposed to be due to differences in the drug and tear fluid kinetics on the ocular surface between the age groups, the conditions in the elderly favouring the drug penetration into the eye.

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Section: Discussionsupporting

confidence: 61%

Mydriatic Effect of Low Dose Phenylephrine

Salminen¹,

Aaltonen²,

Jäntti³

1980

Ophthalmic Res

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“…(7) The converse picture is provided by published reports (Lee, 1958;Hill, 1968;Haddad et al, 1970;Mapstone, 1974b) that phenylephrine can produce a significant increase in pressure yet the angle is unequivocally open to gonioscopy. This can occur in two situations: (a) A pupil moves (Fig.…”

Section: Eyes Dilated With Tropicamidementioning

confidence: 99%

Dilating dangerous pupils.

Mapstone¹

1977

British Journal of Ophthalmology

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“…Doseresponse data have shown 5% phenyl¬ ephrine hydrochloride to be better than a 2.5% solution but about equal to a 10% solution in achieving mydri¬ asis. 1 Other studies have shown no appreciable difference between 10% aqueous and 2.5% aqueous phenyleph¬ rine hydrochloride in dilating the pupil.2-3 Nevertheless, some surgeons believe that a 10% solution is more effective than a 2.5% solution in maintaining intraoperative mydriasis during surgical manipulation, irre¬ spective of the initial mydriatic response.…”

mentioning

confidence: 99%