“…116 Blinded patient-reported measures of overall QOL, social functioning, personal appearance, visual function, and synkinesis severity demonstrated significant postinjection improvements for those in the BT treatment arm (P<.05, all measures) but not for saline placebo group (P>.05, all measures). Evidence from case series has demonstrated that in patients with flaccid paralysis, BT injection to the contralateral lip depressors improves lower-lip symmetry, 117 that injection into the contralateral NLF region improves oral competence, 118 and that injection into the contralateral forehead improves brow symmetry (level IV). 119 In addition, injectable fillers, such as hyaluronic acid, hydroxyapatite, and fat grafts, may be beneficial in the midface and lips (level V).…”