Myelodysplastic Syndrome Presenting with Generalized Cutaneous Granulocytic Sarcomas

Lin, Chia-Shuen; Liang, Rongzhang; Ma, López; Chan, Gcf; Liu, H.W.

doi:10.1159/000205175

Cited by 18 publications

(11 citation statements)

References 2 publications

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“…Eosinophilic myelocytes can also been seen (Lin et al 1990 ). Myelomonocytic or pure monoblastic morphology can be seen (Falini et al 2007 ;Pileri et al 2007 ) (see Fig.…”

Section: Pyoderma Gangrenosum Associated With G-csfmentioning

confidence: 95%

“…Prognosis is poor in patients with MS. MS is considered an equivalent of a diagnosis of acute myeloid leukemia and should be treated with induction chemotherapy (Eshghabadi et al 1986 ;Lin et al 1990 ). Allogeneic hematopoietic cell transplantation carries a higher probability of prolonged survival or cure (Breccia et al 2004 ;Pileri et al 2007 ).…”

Section: Clinical Behaviormentioning

confidence: 99%

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Cutaneous Hematopathology

2014

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“…Eosinophilic myelocytes can also been seen (Lin et al 1990 ). Myelomonocytic or pure monoblastic morphology can be seen (Falini et al 2007 ;Pileri et al 2007 ) (see Fig.…”

Section: Pyoderma Gangrenosum Associated With G-csfmentioning

confidence: 95%

Section: Clinical Behaviormentioning

confidence: 99%

Cutaneous Hematopathology

2014

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“…Cutaneous lesions usually occur on the trunk, scalp and extremities. In general, they are solitary but may be multiple and disseminated 4–11 …”

mentioning

confidence: 99%

“…Myelodysplastic syndrome refers to a heterogeneous group of clonal hematopoietic disorders, characterized by a cellular marrow with impaired morphology and maturation, and peripheral blood cytopenia. The occurrence of cutaneous granulocytic sarcoma in the context of myelodysplastic syndromes is rare and often a sign of poor prognosis 7–16 …”

mentioning

confidence: 99%

Cutaneous granulocytic sarcoma in myelodysplastic syndrome

Câmara¹,

Morais²,

Portugal

et al. 2008

J Cutan Pathol

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Granulocytic sarcoma is an extramedullary tumor of immature cells of granulocytic series, generally associated to acute myelogenous leukemia. The skin is one of the most commonly affected sites. Granulocytic sarcoma can complicate myelodysplastic syndromes and is considered a sign of poor prognosis. They are often misdiagnosed with non-Hodgkin lymphoma of the lymphoblastic type, Burkitt lymphoma and large cell lymphoma. In children, the differential diagnoses also include small, round cell tumors. It is important to diagnose these lesions early because they can precede peripheral blood and bone marrow transformation to acute myelogenous leukemia. We report a case of an elderly patient with myelodysplastic syndrome who developed multiple cutaneous granulocytic sarcoma lesions and discuss prognostic and treatment implications.

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“…[21][22][23][24][25] It can also be associated with myelodysplastic syndrome. 13,26,27 Phenotyping of a leukemic myeloid infiltrate can be easily achieved using flow cytometric immunophenotyping. 5,12 This can also be confirmed using cytogenetics.…”

mentioning

confidence: 99%

The Value of CD34, Myeloperoxidase and Chloracetate Esterase (Leder) Stain in the Diagnosis of Granulocytic Sarcoma

Mourad

Kfoury

2001

Annals of Saudi Medicine

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Background:The differentiation of extramedullary myelogenous leukemia/granulocytic sarcoma (GS) from malignant lymphoma can sometimes be difficult. In the current study, we explored the value of CD34, myeloperoxidase and nonspecific esterase (Leder) stains in differentiating GS from lymphomas. Materials and Methods: Fifteen cases of phenotypically confirmed GS were stained for CD34, myeloperoxidase and Leder stains. The same stains were performed in 16 malignant lymphomas as controls. The GS cases were also immunostained for CD3 and CD20 to detect the incidence of aberrant T and B lymphocyte expression. Results: CD34 was expressed in 7 of the 15 cases of GS (46%). Myeloperoxidase was expressed in 10 of the 15 cases (66%), and Leder stain was positive in 9 cases (60%). All 15 cases had expression of at least one marker; 8 cases had expression of two markers and one case had expression of all 3 markers. None of the lymphomas showed expression of any of the three markers. Five cases (35%) of GS showed T cell antigen expression and 2 (14%) showed B cell antigen expression. Conclusion: Our findings suggest that in cases of GS, the use of the combination of CD34, myeloperoxidase and Leder stains can help reach a definitive diagnosis, especially if lymphoma is difficult to exclude. Expression of B and T cell antigens in such lesions should not rule out the diagnosis of GS.

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Myelodysplastic Syndrome Presenting with Generalized Cutaneous Granulocytic Sarcomas

Cited by 18 publications

References 2 publications

Cutaneous Hematopathology

Cutaneous Hematopathology

Cutaneous granulocytic sarcoma in myelodysplastic syndrome

The Value of CD34, Myeloperoxidase and Chloracetate Esterase (Leder) Stain in the Diagnosis of Granulocytic Sarcoma

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