The Value of CD34, Myeloperoxidase and Chloracetate Esterase (Leder) Stain in the Diagnosis of Granulocytic Sarcoma

Mourad, Walid A.; Kfoury, Hala; H, Al Husseini

doi:10.5144/0256-4947.2001.287

Cited by 17 publications

(9 citation statements)

References 22 publications

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“…However, Mourad et al (8) reported that only 66% cases of myeloid sarcomas express MPO. Traweek et al (9) reported that MPO is the most useful marker for distinguishing myeloid sarcomas, but that the expression of MPO varies with degrees of differentiation.…”

Section: Discussionmentioning

confidence: 99%

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Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature

et al. 2016

Oncology Letters

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Abstract. Myeloid sarcoma is a type of malignant neoplasm composed of myeloblasts that locates extramedullary. The present study reports the case of a 31-year-old female who presented with upper abdominal pain, melena, vomiting and jaundice. The abdominal computed tomography revealed a mass in gastric antrum area and possible infiltration of the duodenum, gallbladder and head of the pancreas, with possible retroperitoneal lymph node metastasis. The tumor grew quickly and led to serious obstructive jaundice. New masses developed in the bilateral orbits and left breast within 2 months of admission. The pathological results of the gastroscopic biopsy and the fine-needle biopsy of the breast revealed myeloid sarcoma. Transhepatic cholangial drainage, radiotherapy and chemotherapy were administered, but the disease reoccurred and became resistant to chemotherapy, so salvage allogenetic peripheral blood stem cell transplantation was performed. The disease relapsed at 5 months post-transplantation, and chemotherapy and donor lymphocytes transfusions were then administered. The patient declined further treatment and succumbed to disease on May 19, 2015. The present study could improve the understanding of myeloid sarcoma and provide a reference for standardized and individualized treatments for this disease.

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Section: Discussionmentioning

confidence: 99%

“…CD20 is a characteristic differentiation antigen of B cells, and it is expressed by B cells from the pre-B cell period until their differentiation into plasma cells (10). The majority of studies consider that myeloid sarcomas are CD20-negative, however, Mourad et al (8) reported that the CD20 expression rate is 13% in myeloid sarcomas.…”

Section: Discussionmentioning

confidence: 99%

Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature

et al. 2016

Oncology Letters

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“…To confirm the final diagnosis of GS, the immunohistochemical detection of MPO-positive cells is useful. Mourad et al (21) and Pileri et al (22) reported that the expression levels of MPO-positive cells in GS were 66 and 83.6%, respectively. Specific CD markers can also be useful.…”

Section: Discussionmentioning

confidence: 98%

Granulocytic sarcoma of the breast: A case report

Huang

Zhou

2015

Oncology Letters

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Abstract. Granulocytic sarcoma (GS) is an unusual type of tumor composed of immature cells outside the bone marrow. The disease exhibits a correlation with acute myeloid leukemia and other myeloproliferative disorders. Although it can invade a number of areas of the body, the involvement of the breast is uncommon. The present study reports the case of a 58-year-old female with a mildly tender lump in the left breast that had been apparent for one year. Available diagnostic techniques, including ultrasound, magnetic resonance imaging and mammography, were systematically used to determine a diagnosis of GS, and lumpectomy and systemic chemotherapy were performed. The patient was satisfied with the result of no local recurrence at the one year follow-up examination. The present study discusses the clinical and pathological characteristics of the present case of GC.

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“…Thereinto, MPO and lysozyme are specific markers of oral primary GS and are associated with the process of tumor cell differentiation. [ 3 , 6 , 45 , 46 ]…”

Section: Discussionmentioning

confidence: 99%

Clinical characteristics and management of primary granulocytic sarcoma of the oral cavity

Hu¹,

Deng²,

Wei³

et al. 2020

Medicine

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Introduction: Granulocytic sarcoma (GS) is a commonly occurring tumor comprising immature myeloid cells, which are usually related to acute or chronic myelocytic leukemia. The tumor rarely precedes leukemia without bone marrow involvement and is called primary GS. Although primary GS can occur in any body part, the involvement of the oral cavity is uncommon. Patient concerns: A 49-year-old woman hospitalized at the Department of Plastic and Maxillofacial Surgery presented with a growing mass in her left maxillary hard palate dating two months back. No obvious physical findings were noted during general examination. She was diagnosed with an oral ulcer at a local clinic, and received antibiotics. However, the symptoms did not improve; the mass became bigger and painful. Diagnosis: An incisional biopsy of the oral mass was performed, the immunohistochemistry showed that the tumor cells tested positive for myeloperoxidase, CD4, BCL-2, KI-67. Bone marrow aspiration was negative for malignant cells, and the laboratory test results revealed only monocytosis. Standard bone marrow cytogenetic analysis showed a normal karyotype and leukemia-related fusion gene detection was normal. Therefore, the final diagnosis was intraoral primary GS. Interventions: The patient was treated with a chemotherapy regimen based on idarubicin and cytarabine arabinoside. Outcomes: After 2 cycles of idarubicin and cytarabine arabinoside regimen chemotherapy, the patient achieved complete remission. The tumor was barely visible in the left maxillary hard palate. There has been no evidence of disease spread and progression after 1 year of follow-up. Conclusions: Careful morphological and immunohistochemical analyses, correlating with clinical data are necessary to establish the diagnosis of oral primary GS. Early aggressive systemic chemotherapy can effectively relieve symptoms, significantly reducing primary GS conversion into acute myelocytic leukemia and prolonging overall survival.

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The Value of CD34, Myeloperoxidase and Chloracetate Esterase (Leder) Stain in the Diagnosis of Granulocytic Sarcoma

Cited by 17 publications

References 22 publications

Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature

Myeloid sarcoma derived from the gastrointestinal tract: A case report and review of the literature

Granulocytic sarcoma of the breast: A case report

Clinical characteristics and management of primary granulocytic sarcoma of the oral cavity

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