Myelopathy in seronegative Sjögren syndrome and/or primary                 progressive multiple sclerosis

Pericot, Imma; Brieva, Luís; Tintoré, Mar; Río, Jordi; Sastre‐Garriga, Jaume; Nos, Carlos; Montalbán, Xavier

doi:10.1191/1352458503ms905oa

Cited by 20 publications

(15 citation statements)

References 19 publications

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“…At least 60 cases of spinal cord involvements in pSS have been reported, indicating that this neurologic complication is not uncommon [47,51,[56][57][58][59][60][61][62]. Acute myelitis is the most frequent form of spinal cord involvement in pSS [51,56].…”

Section: Spinal Cord Involvementmentioning

confidence: 99%

“…Acute myelitis is the most frequent form of spinal cord involvement in pSS [51,56]. The spectrum of acute myelitis is wide in pSS including severe transverse myelitis resulting in tetraparesis or paraparesis and sphincter dysfunction, moderate subacute transverse myelitis, lateral cervical myelitis resulting in hemiplegia, posterior myelopathy with a predominance of sensory symptoms and a recurrent course and Brown-Sequard syndrome [47,51,[56][57][58][59][60][61][62]. Spinal cord MRI revealed extended T2-weighted hyperintensities with a predominant cervical involvement [11].…”

Section: Spinal Cord Involvementmentioning

confidence: 99%

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Central and peripheral neurological complications of primary Sjögren's syndrome

2012

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Section: Spinal Cord Involvementmentioning

confidence: 99%

Section: Spinal Cord Involvementmentioning

confidence: 99%

Central and peripheral neurological complications of primary Sjögren's syndrome

2012

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“…These factors highlight the variable clinical course of SS, such that neurological involvement of SS may be difficult to distinguish from MS or NMO. There is such overlap in clinical and serologic characteristics between SS and NMO that a Sjögren's-NMO spectrum disorder has been proposed, characterized by optic neuritis, [57] myelitis, positive NMO IgG, in addition to positive SS associated auto-antibodies including anti-Ro (anti-SSA) and anti-La (anti-SSB) antibodies [79,80]. The incidence of primary SS has been reported at 4/100,000, with neurological manifestations, commonly myelopathy, occurring in 15-25% [81][82][83].…”

Section: Sjögren's Syndromementioning

confidence: 99%

A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis

2011

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Although multiple sclerosis (MS) is the most common demyelinating disorder of the central nervous system (CNS), it lacks any definitive diagnostic test. Instead, diagnosis of MS primarily depends upon clinical criteria, supported by abnormalities characteristic of MS on para-clinical investigations including magnetic resonance imaging of the brain and spine, in the absence of an alternative explanation for underlying neurologic symptoms. While many of the potential disorders that may mimic MS in routine clinical practice are either extremely rare, or associated with specific and characteristic distinguishing diagnostic features, some inflammatory demyelinating disorders of the CNS may be particularly challenging to distinguish from MS, especially during initial presentation. In particular, acute disseminated encephalomyelitis, neuromyelitis optica, and idiopathic transverse myelitis may closely resemble MS, impeding prompt and accurate diagnosis. In this review, we describe the clinical features, diagnosis, pathology, and treatment of these other CNS demyelinating disorders. In addition, we review relevant features of other CNS inflammatory disorders that may mimic MS, including Sjögren's syndrome, systemic lupus erythematosus, Behçet's disease, and primary CNS vasculitis.

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“…The cognitive deficits frequently involve frontal executive functions, and manifest as dysinhibition and difficulties with attention and abstraction. Memory deficit and visuospatial dysfunction are also often present (26,27).…”

Section: Sjögren's Syndromementioning

confidence: 99%

Central Nervous System Manifestations in Rheumatic Diseases

Cojocaru¹,

Cojocaru²,

Siloşi³

et al. 2011

Journal of Medical Biochemistry

110

104

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Kratak sadr`aj: Pacijenti sa vi{esistemskim reumatskim stanjima mogu imati i bolest koja poga|a centralni nervni sistem (CNS). Manifestacije centralnog nervnog sistema razlikuju se prema lokaciji lezije i kre}u se od lokalnih na laza (npr. stanja sli~na {logu), iako su ozbiljne neurolo{ke komplikacije kod reumatskih bolesti naizgled retke. U naj ~e -{}e odlike neurolo{kih poreme}aja kod reumatskih bo lesti ubrajaju se cerebralna ishemija i psihijatrijski simp to me. Postoji malo podataka o prevalenci neurolo{kih obo lje nja kod pacijenata sa reumatolo{kom dijagnozom. Zahva}enost CNS mo`e biti upadljiva rana ili trenutna odlika, koja se mo`e manifestovati na vrlo razli~ite na~ine. Situacija je jasnija kod sindroma CNS koji se mogu pripisati sistemskom lupusu eritematodesu i u pogledu novih saz na nja o centralnom mehanizmu uklju~enom u mani festacije Sjogrenovog sindroma i reumatoidnog artritisa. Velika zahva }enost CNS ukazuje na lo{u prognozu i visoku stopu smrtnosti. Dajemo pregled spektra neurolo{kih oboljenja kod pacijenata sa reumatolo{kim dijagnozama.

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Myelopathy in seronegative Sjögren syndrome and/or primary progressive multiple sclerosis

Abstract: Some MS patients, predominantly women over 45 years of age, with progressive spastic paraparesis, antiextractable nuclear antigen antibodies (Ro/SS-A or La/SS-B) negative and with abnormalities in spinal cord MRI, may have SS as an additional or alternative diagnosis.

Cited by 20 publications

References 19 publications

Central and peripheral neurological complications of primary Sjögren's syndrome

Central and peripheral neurological complications of primary Sjögren's syndrome

A differential diagnosis of central nervous system demyelination: beyond multiple sclerosis

Central Nervous System Manifestations in Rheumatic Diseases

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