2019
DOI: 10.1111/ijlh.13005
|View full text |Cite
|
Sign up to set email alerts
|

Myeloproliferative neoplasms: Diagnostic workup of the cythemic patient

Abstract: Elevated peripheral blood (PB) cell counts, such as leukocytosis, thrombocytosis, and polycythemia, are often the presenting symptom in patients with myeloproliferative neoplasms (MPN). Because cythemias are nonspecific and may reflect either a reactive or neoplastic process, diagnostic workup of these patients is complicated and requires integration of numerous diagnostic modalities. Careful morphologic evaluation of the PB smear may provide insights into the underlying cause of the abnormal counts (such as t… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1

Citation Types

0
16
0
3

Year Published

2021
2021
2024
2024

Publication Types

Select...
7

Relationship

0
7

Authors

Journals

citations
Cited by 13 publications
(19 citation statements)
references
References 41 publications
0
16
0
3
Order By: Relevance
“…THE MYELOPROLIFERATIVE NEOPLASMS (MPNs) are a group of disorders that share overlapping clinical, pathological and genetic features that result in abnormal proliferation of mature myeloid cell lineages and a predisposition to developing bone marrow fibrosis and acute myeloid leukaemia. 1,2 MPNs are uncommon, with incidence rates quoted as 2-6 per 100,000 per year. 3,4 The four classic MPNs, which will be discussed in this article, include polycythaemia vera, essential thrombocytosis, primary myelofibrosis (PMF) and chronic myeloid leukaemia (CML).…”
Section: Discussionmentioning
confidence: 99%
See 2 more Smart Citations
“…THE MYELOPROLIFERATIVE NEOPLASMS (MPNs) are a group of disorders that share overlapping clinical, pathological and genetic features that result in abnormal proliferation of mature myeloid cell lineages and a predisposition to developing bone marrow fibrosis and acute myeloid leukaemia. 1,2 MPNs are uncommon, with incidence rates quoted as 2-6 per 100,000 per year. 3,4 The four classic MPNs, which will be discussed in this article, include polycythaemia vera, essential thrombocytosis, primary myelofibrosis (PMF) and chronic myeloid leukaemia (CML).…”
Section: Discussionmentioning
confidence: 99%
“…Uncommonly, patients may present with leucostasis manifesting as pulmonary (dyspnoea, hypoxia) or neurological (visual changes, headaches, dizziness) symptoms. 1,10 In polycythaemia vera, microvascularrelated symptoms such as headaches, dizziness, visual disturbances, plethora, erythromelalgia and aquagenic pruritus may be evident. Erythromelalgia can be described as episodic intense erythema and burning pain in response to heat stimuli.…”
Section: Disease Relatedmentioning
confidence: 99%
See 1 more Smart Citation
“…In contrast, essential thrombocytosis is associated with the myeloproliferative neoplasms and results from unregulated abnormal platelet production from the bone marrow progenitor cells. The abnormal proliferation of mature bone marrow cells is observed in all three lineages: leukocytes, erythrocytes, and megakaryocytes ( 6 ).…”
Section: Introductionmentioning
confidence: 99%
“…Since various non-hematologic disorders can also cause leukocytosis, thrombocytosis, and polycythemia, careful evaluation of the morphology in PB cells is critical for accurate initial diagnoses of Ph-negative MPNs, especially for detecting abnormalities in the cells. For example, immature granulocytes and nucleated RBCs are known to be observed in MF, including overt PMFs and secondary MFs 6,7 .…”
mentioning
confidence: 99%