Mykobakterieninfektionen der Haut

Buhl, Timo; Schön, Michael P.

doi:10.1007/978-3-662-49544-5_15

Cited by 2 publications

(8 citation statements)

References 30 publications

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“…Acid‐fast bacteria can be identified with special staining techniques (Ziehl‐Neelsen, Kinyoun, or auramine‐rhodamine). However, as at least 1,000–10,000 pathogens/ml are required for reliable detection and the bacterial load in cutaneous tuberculosis is low; acid‐fast bacteria are observed in only 0 %–5 % of all cases . Immunohistochemical localization using antibodies against M. tuberculosis is more sensitive .…”

Section: Histopathologymentioning

confidence: 99%

“…Mycobacterium leprae cannot be grown in conventional microbiological cultures. Cultivation in the paws of mice ( Mus musculus ) or armadillos ( Dasypus novemcinctus ) is possible, though not part of routine diagnostic tests .…”

Section: Microbiological Culturementioning

confidence: 99%

“…As different NTM require versatile media conditions according to their metabolic needs (such as iron supplementation for M. haemophilum ), clinicians should inform microbiologists about the suspected mycobacterial species and the clinical symptoms. Results of cultures are obtained after a few days ( M. fortuitum complex) or up to 2–4 weeks ( M. marinum ) (Figure c) .…”

Section: Microbiological Culturementioning

confidence: 99%

“…Mycobacterial skin infections are caused by members of the Mycobacterium (M.) tuberculosis complex (particularly M. tuberculosis ), by M. leprae , or by non‐tuberculous mycobacteria (NTM, including M. marinum , M. ulcerans , and the M. fortuitum complex). Clinical symptoms are remarkably variable (Figure ) and depend on the type (species and strain) and quantity of pathogens (multibacillary vs. paucibacillary forms) as well as the patient's immunological status (normergia, hyperergia, or anergia) . Consequently, a broad range of differential diagnoses has to be considered when dealing with cutaneous mycobacterioses.…”

Section: Introductionmentioning

confidence: 99%

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Diagnosis of mycobacterial skin infections

Kromer

Fabri

Schlapbach

et al. 2019

J Deutsche Derma Gesell

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Summary The diagnosis of cutaneous mycobacterial infections may be challenging. Owing to the broad spectrum of their clinical presentations, mycobacterioses have to be considered as differential diagnoses to many inflammatory dermatoses. Diagnostic measures comprise histology including special staining, cultures and molecular microbiological examinations as well as the detection of cellular immune reactions of the patient by means of interferon‐γ release assays and skin testing. Clinicians should know the appropriate use and combination of procedures to diagnose mycobacterioses quickly and correctly and to avoid costs and delays caused by unnecessary examinations. This mini review summarizes advantages, limitations, and pitfalls of diagnostic methods for mycobacterial skin infections.

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Section: Histopathologymentioning

confidence: 99%

Section: Microbiological Culturementioning

confidence: 99%

Section: Microbiological Culturementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Diagnosis of mycobacterial skin infections

Kromer

Fabri

Schlapbach

et al. 2019

J Deutsche Derma Gesell

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“…Mykobakterielle Hautinfektionen werden durch Mitglieder des Mycobacterium (M.)‐tuberculosis ‐Komplexes (insbesondere M. tuberculosis ), durch M. leprae oder durch nichttuberkulöse Mykobakterien (NTM, einschließlich M. marinum , M. ulcerans und dem M.‐fortuitum ‐Komplex) verursacht. Die klinischen Symptome sind erstaunlich variabel (Abbildung ) und abhängig vom Typ (Spezies und Stamm) und der Anzahl der Erreger (multibazilläre vs. paucibazilläre Formen) sowie vom Immunstatus des Patienten (Normergie, Hyperergie oder Anergie) . Daher muss bei kutanen Mykobakteriosen ein breites Spektrum von Differenzialdiagnosen in Betracht gezogen werden.…”

Section: Introductionunclassified

Diagnose mykobakterieller Hautinfektionen

Kromer

Fabri

Schlapbach

et al. 2019

J Deutsche Derma Gesell

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Zusammenfassung Die Diagnose kutaner mykobakterieller Infektionen kann eine Herausforderung darstellen. Aufgrund der großen Bandbreite ihres klinischen Erscheinungsbildes müssen Mykobakteriosen bei vielen entzündlichen Dermatosen differenzialdiagnostisch in Betracht gezogen werden. Die diagnostischen Maßnahmen umfassen die histologische Analyse einschließlich Spezialfärbungen, Kulturen und molekulare mikrobiologische Untersuchungen sowie die Erfassung zellulärer Immunreaktionen des Patienten anhand von Interferon‐γ‐Release‐Assays und Hauttests. Kliniker sollten die angemessene Anwendung und Kombination der Verfahren zur schnellen und korrekten Diagnose von Mykobakteriosen kennen, um Kosten und Verzögerungen aufgrund unnötiger Untersuchungen zu vermeiden. Dieser Minireview fasst die Vorteile, Einschränkungen und Fallstricke der Diagnoseverfahren für mykobakterielle Infektionen der Haut zusammen.

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Mykobakterieninfektionen der Haut

Cited by 2 publications

References 30 publications

Diagnosis of mycobacterial skin infections

Diagnosis of mycobacterial skin infections

Diagnose mykobakterieller Hautinfektionen

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