Myocardial changes during the progression of left ventricular pressure-overload by renal hypertension or aortic constriction: Myosin, myosin ATPase and collage

Kozlovskis, Patricia L.; Fieber, Lynne A.; Pruitt, Delicia; Bailey, B.K.; Smets, Marcel J.D.; Bassett, Arthur L.; Kimura, Shin-ichi; Myerburg, Robert J.

doi:10.1016/s0022-2828(87)80549-7

Cited by 7 publications

(1 citation statement)

References 34 publications

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“…1979], Mass of the contractile proteins, activity of the contractile machinery and collagen ultimately contribute to the functional characteristics of the hypertrophied myo cardium. Kozlovskis et al [1987] concluded that, when the ratio between mass of contractile protein and connective tissue is altered, it impairs the function and the limitation of the myocardium to increase further the protein synthe sis may lead to the synthesis of structural collagen to meet the new work demands. In addition to ultrastructural studies on the myocytes at the sites of collagen accumula tion.…”

Section: Discussionmentioning

confidence: 99%

Changes in Myosin Isozyme Expression during Cardiac Hypertrophy in Hyperthyroid Rabbits

Seiden¹,

Srivatsan²,

Navidad³

1989

Cells Tissues Organs

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The myosin isozyme distribution in the left ventricle and in the interventricular septum of rabbits was studied after 3 7,11,14 and 21 days of L-thyroxine (500 µg/kg/day) administration. Histochemical procedures were employed to identify V₁ and V₃ by their Ca²⁺ ATPase activity and their proportions were quantified through polyacrylamide gel electrophoresis. In the left ventricle, the subepicardium was the first to show the shift fromV₃ to V₁ followed by the subendocardium. The intermediate region became heterogeneous by 11 days and remained so until 21 days. The right subendocardial and the intermediate regions of the interventricular septum were heterogeneous in the normal rabbit and hyperthyroidism resulted in a shift from V₃ to V₁ in both the right and left subendocardial regions of the septum. Like the left ventricle, the intermediate region of the interventricular septum remained heterogeneous. Localized accumulations of collagen were seen in all regions of the left ventricle and interventricular septum. From these results we conclude that in thyrotoxic myocardial hypertrophy the isozymic shift from V₃ to V₁ is progressive, region-specific and is directly correlated with the period of hyperthyroidism in the first 2 weeks. Prolonged hyperthyroidism results in localized accumulation of collagen which does not exhibit any regional specificity.

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Section: Discussionmentioning

confidence: 99%