Myocardial Damage Biomarkers Dynamics After Extracardiac Surgery in Coronary Heart Disease Patients Taking Trimetazidine MR

Большедворская, О. А.; Протасов, К. В.; Батунова, Е. В.; Дворниченко, В. В.; Баторова, Е. Р.; Казанкова, Е. Г.

doi:10.15829/1560-4071-2017-4-93-98

Cited by 3 publications

(2 citation statements)

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“…Средний уровень БСЖК статистически значимо увеличился с дооперационного 0,47 (0,24-0,8) нг/мл до 2,6 (1,5-4,0) через 24 ч после операции с последующим снижением до 1,1 (0,6-2,6) через 48 ч. До вмешательства значение БСЖК выше верхней границы нормы (5 нг/мл) выявлено у одного пациента, через суткиу 16 (22,2%), через двое -у 8 (11,1%), за весь 48-часовой период -у 18 (25,0%). Таким образом, при использовании БСЖК в качестве маркера ПМВО, частота последнего достигает 25% [55].…”

Section: другие биомаркеры в диагностике пмво и прогнозировании послеunclassified

“…Прием препарата был ассоциирован с меньшими, по сравнению с контролем, послеоперационными уровнями БСЖК и NT-proBNP и долей пациентов с ПМВО. Повышенный сТнI >0,1 нг/мл отмечен у двоих пациентов контрольной группы [55].…”

Section: профилактика пмвоunclassified

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Myocardial injury after non-cardiac surgery: current state of the problem and unresolved issues

Протасов¹,

Большедворская²

2019

Russ J Cardiol

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В обзоре на основе данных литературы последнего десятилетия, рекомендаций международных и национальных профессиональных сообществ обобщены сведения о повреждении миокарда после внесердечных хирургических операций (ПМВО). Отражен растущий интерес к этой междисциплинарной проблеме, вызванный широкой распространенностью и тесной ассоциацией ПМВО со смертностью в послеоперационном периоде. Проанализированы наблюдательные исследования, посвященные поиску факторов риска и механизмов повреждения миокарда при хирургическом вмешательстве на других органах. Сделан акцент на роли бессимптомного повышения сердечных тропонинов, не уступающего по своей клинической и прогностической значимости послеоперационному инфаркту миокарда. Изложены современные подходы к диагностике и профилактике ПМВО. С учетом результатов недавно завершившегося первого рандомизированного контролируемого исследования MANAGE (2018) обсуждены возможности и перспективы лечения ПМВО. Определены нерешенные вопросы и направления дальнейших исследований в этой области. Ключевые слова: повреждение миокарда, внесердечные хирургические операции, тропонин. Конфликт интересов: не заявлен. 1 Иркутская государственная медицинская академия последипломного образования-филиал ФГБОУ ДПО Российская медицинская академия непрерывного профессионального образования Минздрава России, Иркутск;

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Section: другие биомаркеры в диагностике пмво и прогнозировании послеunclassified

Section: профилактика пмвоunclassified

Myocardial injury after non-cardiac surgery: current state of the problem and unresolved issues

Протасов¹,

Большедворская²

2019

Russ J Cardiol

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Myocardial injury in noncardiac surgery – diagnostic difficulties

Мурашко

Pasechnik

Бернс

2020

Kompleks. probl. serdečno-sosud. zabol.

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A new concept was adopted by the Fourth Universal Definition of MI Expert Consensus Document in 2018 – periprocedural myocardial injury after cardiac- and noncardiac interventions, which is distinct from myocardial infarction.It is difficult to diagnose a heart attack and myocardial damage after noncardiac surgery.Postoperative myocardial injury increases mortality and worsens the long-term prognosis and quality of treatment.The quality of surgical care is determined by surgical techniques and the course of the postoperative period. Although complications often negate the results of brilliantly performed surgery, many of them would happen irrespective of surgeon`s actions. The development of complications determining the outcome of treatment can be associated with cardiac pathology. Cardiac complications may develop due to existing comorbidities, hemodynamic instability during surgery, cardiotoxic effect of drugs, etc. In 40% of cases, the risk of cardiac death after noncardiac surgery is associated with the development of perioperative myocardial infarction or myocardial injury. Myocardial infarction is the most demonstrative complication, although it is difficult to diagnose in the perioperative period in case of asymptomatic course. The link between postoperative myocardial infarction and lethality is beyond doubt. Adopted in 2018, the Fourth Universal Definition of MI Expert Consensus Document introduced a new concept of periprocedural myocardial injury after cardiac- and noncardiac interventions, which are distinct from myocardial infarction. Myocardial injury requires laboratory tests to be diagnosed. However, myocardial injury itself affects postoperative mortality and significantly worsens the long-term prognosis and quality of treatment. This article reports the features of the etiopathogenetic mechanisms of cardiac complications during surgical care, as well as the multifactorial genesis of myocardial injury. The analysis of modern scientific literature on the diagnosis of myocardial damage is given. The need for early diagnosis of myocardial damage to create optimal management tactics for patients undergoing noncardiac interventions is demonstrated.

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Current views on the role of fatty acids in the diagnosis of cardiovascular diseases (review)

Astafeva

Zharkov

Ясенявская

et al. 2021

Sibirskij nauchnyj medicinskij zhurnal

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An additional informative tool in the diagnosis of cardiovascular diseases in the early stages can be the analysis of changes in the fatty acid profile, which can be considered as a marker of various pathological conditions. The study of the effects of fatty acids and the mechanisms of changes in the fatty acid profile in connection with cardiovascular diseases remains relevant. We have analyzed modern data from foreign and domestic literature on issues related to the importance of fatty acids as possible markers in the diagnosis of cardiovascular diseases. Basic information about the structure of fatty acids, their functions in the human body, the relationship between the level of free fatty acids and indicators of the development of pathological processes of the cardiovascular system is presented. The factors influencing the dynamics of fatty acid concentrations both in normal conditions and during the development of pathological processes are reflected. The processes of biochemical modification of the fatty acid composition of the lipid matrix of the cell membrane are considered. The expediency of using fatty acids, together with some protein markers in the diagnosis of diseases of the cardiovascular system, has been shown. The collection and analysis of the accumulated information on the role of fatty acids helps to optimize the use of laboratory markers to determine the stages of pathogenesis of circulatory organ damage, to develop a system for evaluating the effectiveness of therapy for cardiovascular diseases, and to create a set of laboratory and instrumental tests for monitoring the condition of patients.

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Myocardial Damage Biomarkers Dynamics After Extracardiac Surgery in Coronary Heart Disease Patients Taking Trimetazidine MR

Cited by 3 publications

References 4 publications

Myocardial injury after non-cardiac surgery: current state of the problem and unresolved issues

Myocardial injury after non-cardiac surgery: current state of the problem and unresolved issues

Myocardial injury in noncardiac surgery – diagnostic difficulties

Current views on the role of fatty acids in the diagnosis of cardiovascular diseases (review)

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