Myocardial dysfunction during H1N1 influenza infection

Fagnoul, David; Pasquier, Pierre; Bodson, Laurent; Ortiz, Julián Arias; Vincent, Jean‐Louis; Backer, Daniel De

doi:10.1016/j.jcrc.2013.01.010

Cited by 59 publications

(42 citation statements)

References 31 publications

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“…According to our protocol, the echocardiographic examination is transthoracic (TTE), transthoracic (TTE), or both, according to the best acoustic window (Esaote MyLab ™ 30Gold Cardiovascular, Esaote S.p.A, Genoa, Italy). The LV ejection fraction (LVEF) was estimated by ‘eyeball’ examination on short‐axis views . LV systolic dysfunction was defined as LV ejection fraction less than 50% .…”

Section: Methodsmentioning

confidence: 99%

Pulmonary vascular dysfunction in refractory acute respiratory distress syndrome before veno‐venous extracorporeal membrane oxygenation

Lazzeri

Cianchi

Bonizzoli

et al. 2015

Acta Anaesthesiol Scand

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In patients with refractory ARDS immediately before ECMO implantation, the prevalence of acute cor pulmonale is low (9.5%). Survival is associated with higher LVEF and lower systolic pulmonary arterial pressure. These findings support the idea that echocardiographic assessment of pulmonary artery pressure in patients with refractory ARDS before VV-ECMO implantation may have value for risk-stratification.

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Section: Methodsmentioning

confidence: 99%

Pulmonary vascular dysfunction in refractory acute respiratory distress syndrome before veno‐venous extracorporeal membrane oxygenation

Lazzeri

Cianchi

Bonizzoli

et al. 2015

Acta Anaesthesiol Scand

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“…An echocardiographic study of 28 patients presenting with ILI to a hospital in Turkey revealed a global myocardial performance index (sum of isovolumetric contraction time (ICT) and isovolumetric relaxation time (IRT) divided by ejection time (ET); higher values correspond to increased cardiac dysfunction) that was significantly higher in 2009 H1N1 infected patients as compared to patients with non-influenza related ILI (78). Similarly, a Belgian study using echocardiography to evaluate the incidence and hemodynamic consequences of right and left ventricular dysfunction in critically ill patients with 2009 H1N1 infection found that 72% of the 39 patients evaluated displayed abnormal ventricular function; forty-six percent (n=13) had isolated left ventricular dysfunction, 39% (n=11) had isolated right ventricular abnormalities and 14% (n=4) had biventricular dysfunction (79). Interestingly, while left ventricular function normalized after an initial decline, right ventricular abnormalities tended to worsen over the course of illness.…”

Section: Influenza-associated Severe Diseasementioning

confidence: 99%

Global Burden of Influenza as a Cause of Cardiopulmonary Morbidity and Mortality

Fischer

Gong

Bhagwanjee

et al. 2014

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Severe acute respiratory infections (SARI), including influenza, are a leading cause of cardiopulmonary morbidity and mortality worldwide. Until recently the epidemiology of influenza was limited to resource-rich countries. Emerging epidemiological reports characterizing the 2009 H1N1 pandemic however suggest that influenza exerts an even greater toll in low-income resource constrained environments where it is the cause of 5–27% of all SARI. The increased burden of disease in this setting is multifactorial and likely is the results of higher rates of comorbidities such as HIV, decreased access to healthcare including vaccinations and antiviral medications, and limited healthcare infrastructure including oxygen therapy or critical care support. Improved global epidemiology of influenza is desperately needed in order to guide allocation of life saving resources including vaccines, antiviral medications, and direct the improvement of basic health care in order to mitigate the impact of influenza infection on the most vulnerable populations.

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“…Nevertheless, a pure causative association between infection and both AHF and CHF development is still elusive. Influenza infection may induce acute, direct myocardial dysfunction through the stimulation of immune system and inflammation [15, 16]. This derives from histologically evident direct myocardial injury, myocarditis, and myocyte necrosis (found in myocardial tissue samples after influenza-related deaths).…”

Section: Influenza Infection and Heart Failurementioning

confidence: 99%

Influenza infection and heart failure—vaccination may change heart failure prognosis?

et al. 2017

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The interaction of influenza infection with the pathogenesis of acute heart failure (AHF) and the worsening of chronic heart failure (CHF) is rather complex. The deleterious effects of influenza infection on AHF/CHF can be attenuated by specific immunization. Our review aimed to summarize the efficacy, effectiveness, safety, and dosage of anti-influenza vaccination in HF. In this literature review, we searched MEDLINE and EMBASE from January 1st 1966 to December 31st, 2016, for studies examining the association between AHF/CHF, influenza infections, and anti-influenza immunizations. We used broad criteria to increase the sensitivity of the search. HF was a prerequisite for our search. The search fields used included “heart failure,” “vaccination,” “influenza,” “immunization” along with variants of these terms. No restrictions on the type of study design were applied. The most common clinical scenario is exacerbation of pre-existing CHF by influenza infection. Scarce evidence supports a potential positive association of influenza infection with AHF. Vaccinated patients with pre-existing CHF have reduced all-cause morbidity and mortality, but effects are not consistently documented. Immunization with higher antigen quantity may confer additional protection, but such aggressive approach has not been generally advocated. Further studies are needed to delineate the role of influenza infection on AHF/CHF pathogenesis and maintenance. Annual anti-influenza vaccination appears to be an effective measure for secondary prevention in HF. Better immunization strategies and more efficacious vaccines are urgently necessary.

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Myocardial dysfunction during H1N1 influenza infection

Cited by 59 publications

References 31 publications

Pulmonary vascular dysfunction in refractory acute respiratory distress syndrome before veno‐venous extracorporeal membrane oxygenation

Pulmonary vascular dysfunction in refractory acute respiratory distress syndrome before veno‐venous extracorporeal membrane oxygenation

Global Burden of Influenza as a Cause of Cardiopulmonary Morbidity and Mortality

Influenza infection and heart failure—vaccination may change heart failure prognosis?

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