Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels

Gregolin, Carlo; Nascimento, Milena do; Souza, Sérgio Luiz Borges de; Mota, Gustavo Augusto Ferreira; Bomfim, Gisele Facholi; Luvizotto, Renata de Azevedo Melo; Sugizaki, Mário Mateus; Bazan, Silméia Garcia Zanati; Campos, Dijon Henrique Salomé de; Dias, Marianne Camargos; Corrêa, Camila Renata; Cicogna, Antônio Carlos; Nascimento, André Ferreira do

doi:10.1016/j.arcmed.2020.11.004

Cited by 13 publications

(10 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serum and intrahepatic levels of IL-6 are also strongly elevated in patients with acute and chronic liver diseases ( Streetz et al, 2003 ). Previous studies showed that the levels of TNF-α and IL-6 were significantly increased in experimental animals exposed to TAA ( Abdul-Hamid et al, 2017 , Ali et al, 2021 , Elnfarawy et al, 2021 , Gowifel et al, 2020 , Gregolin et al, 2021 , Han et al, 2021 , Ibrahim et al, 2018 ).…”

Section: Discussionmentioning

confidence: 95%

Hematological and biochemical investigations on the effect of curcumin and Thymoquinone in male mice exposed to Thioacetamide

Al-Attar

2022

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

Currently, living organisms are increasingly exposed to many toxic chemicals in the environment. These substances pose a threat to human life, other living organisms and ecosystem. In fact, there is an increasing requirement to search for safe therapeutic sources today. Medicinal plants and natural products have become of great importance globally because of their therapeutic potential and medicinal properties, as well as their availability and the absence of harmful side effects for most of them. The present study was designed to explore the potential protective effect of curcumin (CUR) and thymoquinone (TQ) in male rats exposed to thioacetamide (TAA). The experimental mice were divided into eight groups. Group 1 was served as control. Group 2 was exposed to 50 mg/ kg body weight of TAA. Group 3 was exposed to CUR and TAA. Mice of group 4 were treated with TQ and TAA. Mice of group 5 were exposed to CUR plus TQ and TAA. Group 6 was supplemented with CUR. Group 7 was subjected to TQ. Mice of group 8 were treated with CUR and TQ. Hematological and biochemical alterations were evaluated after one month. Significant increases of white blood corpuscles (WBC), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), total bilirubin (TB), tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) values were observed in group 2, while the values of red blood corpuscles (RBC), hemoglobin (Hb(, hematocrit (Hct), glutathione (GSH) and superoxide dismutase (SOD) were statistically decreased. Treatment with CUR, TQ and their combination inhibited the hematological and biochemical alterations induced by TAA toxicity. Moreover, the most protective effect was observed in mice treated with CUR plus TQ. These new results suggested that the protective effect of CUR and TQ attributed to their antioxidant properties.

show abstract

Section: Discussionmentioning

confidence: 95%

Hematological and biochemical investigations on the effect of curcumin and Thymoquinone in male mice exposed to Thioacetamide

Al-Attar

2022

Saudi Journal of Biological Sciences

View full text Add to dashboard Cite

show abstract

“…Furthermore, our results showed that, inhibition of IDO was associated with a significant reduction in circulating CRP and IL-6 concentrations in BDL groups. CRP level markedly correlates with the severity of cirrhosis and IL-6 is highly associated with the cirrhosis mortality and the rate of CCM occurrence (Gregolin et al, 2020;Lahdou et al, 2013). Therefore, the reduction of CRP and IL-6 can be proposed as an additional protective effect of 1-MT on cirrhosis complications.…”

Section: Discussionmentioning

confidence: 99%

1-Methyl tryptophan, an indoleamine 2,3-dioxygenase inhibitor, attenuates cardiac and hepatic dysfunction in rats with biliary cirrhosis

Shayesteh

Guillemin

Rashidian

et al. 2021

European Journal of Pharmacology

View full text Add to dashboard Cite

“…Furthermore, an autopsy study has shown ventricular hypertrophy, cardiac valve calcification, interstitial edema, fibrosis in myocytes, and coronary artery atherosclerosis in cirrhotic patients [ 65 ]. Cardiomyopathy as systolic and diastolic abnormalities, inotropic and chronotropic dysfunction, increased plasma levels of myocardial enzymes, myocyte swelling and hypertrophy, and gross abnormalities in cardiomyocytes in histological examinations have also been reported in animal models of cirrhosis and HE [ 66 , 67 , 68 , 69 ]. Reduced response to vasoconstrictors and accumulation of circulatory vasodilators, such as nitric oxide, carbon monoxide, and endocannabinoids explain the suppression of systemic vascular resistance in liver failure [ 70 , 71 , 72 , 73 ].…”

Section: Factors That May Indirectly Affect the Efficacy Of Glymphati...mentioning

confidence: 99%

The Glymphatic System May Play a Vital Role in the Pathogenesis of Hepatic Encephalopathy: A Narrative Review

Sepehrinezhad

Larsen

Ahmadabad

et al. 2023

Cells

View full text Add to dashboard Cite

Hepatic encephalopathy (HE) is a neurological complication of liver disease resulting in cognitive, psychiatric, and motor symptoms. Although hyperammonemia is a key factor in the pathogenesis of HE, several other factors have recently been discovered. Among these, the impairment of a highly organized perivascular network known as the glymphatic pathway seems to be involved in the progression of some neurological complications due to the accumulation of misfolded proteins and waste substances in the brain interstitial fluids (ISF). The glymphatic system plays an important role in the clearance of brain metabolic derivatives and prevents aggregation of neurotoxic agents in the brain ISF. Impairment of it will result in aggravated accumulation of neurotoxic agents in the brain ISF. This could also be the case in patients with liver failure complicated by HE. Indeed, accumulation of some metabolic by-products and agents such as ammonia, glutamine, glutamate, and aromatic amino acids has been reported in the human brain ISF using microdialysis technique is attributed to worsening of HE and correlates with brain edema. Furthermore, it has been reported that the glymphatic system is impaired in the olfactory bulb, prefrontal cortex, and hippocampus in an experimental model of HE. In this review, we discuss different factors that may affect the function of the glymphatic pathways and how these changes may be involved in HE.

show abstract

Myocardial Dysfunction in Cirrhotic Cardiomyopathy is Associated with Alterations of Phospholamban Phosphorylation and IL-6 Levels

Cited by 13 publications

References 57 publications

Hematological and biochemical investigations on the effect of curcumin and Thymoquinone in male mice exposed to Thioacetamide

Hematological and biochemical investigations on the effect of curcumin and Thymoquinone in male mice exposed to Thioacetamide

1-Methyl tryptophan, an indoleamine 2,3-dioxygenase inhibitor, attenuates cardiac and hepatic dysfunction in rats with biliary cirrhosis

The Glymphatic System May Play a Vital Role in the Pathogenesis of Hepatic Encephalopathy: A Narrative Review

Contact Info

Product

Resources

About