Myocardial imaging with a new transpulmonary lipid-fluorocarbon echo contrast agent: Experimental studies in pigs

Grauer, Susan E.; Pantely, George A.; Xu, Jinping; Ge, Shuping; Giraud, G; Shiota, Takahiro; Sahn, David J.

doi:10.1016/s0002-8703(96)90002-2

Cited by 28 publications

(10 citation statements)

References 38 publications

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“…Such reactions are known to occur from ultrasound contrast agents, particularly in pigs, including Definity [8], Albunex [9] and Sonovue [10]. Both Definity and Sonovue have associated warnings concerning possible human reactions.…”

Section: Methodsmentioning

confidence: 99%

Contrast-Enhanced Diagnostic Ultrasound Causes Renal Tissue Damage in a Porcine Model

Miller

Dou

Wiggins

2010

Journal of Ultrasound in Medicine

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Objective Glomerular capillary hemorrhage (GCH) has been reported and confirmed as a consequence of contrast-enhanced diagnostic ultrasound (CEDUS) of rat kidney. This study assessed renal tissue injury in the larger porcine model. Methods The right kidneys of anesthetized pigs were imaged in 8 groups of 4 pigs. A Vingmed System Five (General Electric Co. Cincinnati OH) was used at 1.5 MHz in B-mode to intermittently scan the kidney at 4 s intervals. A Sequoia 512 (Acuson, Mountain View CA) was used in the 1.5 MHz Cadence CPS mode with intermittent agent-clearance bursts at 4 s intervals. Kidneys were scanned transabdominally, or after laparotomy through a saline standoff. The Sequoia 512 probe was placed in contact with the kidney for one group. Definity (Lantheus Medical Imaging, N. Billerica, MA) was infused at 4 μl/kg/min (diluted 33:1 in saline) for 4 min during scanning. Results Blood-filled urinary tubules were evident on the kidney surface for all groups, except for the group with the probe in contact with the kidney. GCH was found by histology in 31.7 % ± 9.8 % of glomeruli in the center of the scan plane for 1.7 MPa transabdominal scanning and 1.5 % ± 2.9 % of glomeruli in sham samples (P<0.05). In addition, hematuria was detected after scanning, and tubular obstruction occurred in some nephrons. Conclusion Renal tissue damage was induced by CEDUS in the porcine model. This result, together with previous studies in rats, support an hypothesis that GCH would occur in humans from similar CEDUS.

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Section: Methodsmentioning

confidence: 99%

Contrast-Enhanced Diagnostic Ultrasound Causes Renal Tissue Damage in a Porcine Model

Miller

Dou

Wiggins

2010

Journal of Ultrasound in Medicine

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“…These agents were able to provide transpulmonary blood pool contrast useful for cardiac imaging: after intravenous injection, microbubble contrast signal from the blood in the left ventricle was obtained. Circulation lifetime of these microbubbles in the bloodstream was rather short (seconds), so the second generation of microbubbles was brought to clinical practice, which contained biocompatible fluorinated gases with low solubility in blood [5–7]. Attempts to expand the indication of second generation microbubble agents from the approved “endocardial border delineation and left ventricle opacification” to myocardial perfusion brought a variety of clinical trials, large and small scale [14,15], but are yet to gain an approved indication status.…”

Section: Perfusion Studies With Contrast Ultrasoundmentioning

confidence: 99%

“…Vibration occurs with an amplitude of ~2cm and ~4000 rpm, for less than a minute. It results in the formation of gas microbubbles stabilized with a lipid shell dispersed in the aqueous phase [7]. Manufacturing process is easy and quick (Figure 5 and Supplement Video 2): bubbles can be prepared by the patient bedside, in the doctor’s office or in the hospital pharmacy, to be used within hours.…”

Section: Ultrasound Molecular Imaging With Ultrasound Contrastmentioning

confidence: 99%

“…Such agents, based on gas-filled microspheres, were proposed decades ago [1,2], but are only now starting to gain wider clinical acceptance. Blood pool agents represent the first [3,4] and second [5–7] generations of ultrasound contrast. Targeted microbubbles that provide contrast for ultrasound molecular imaging have already reached clinical trials stage [8].…”

Section: Introductionmentioning

confidence: 99%

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Ultrasound Contrast Materials in Cardiovascular Medicine: from Perfusion Assessment to Molecular Imaging

Klibanov

2013

J. of Cardiovasc. Trans. Res.

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Ultrasound imaging is widely used in cardiovascular diagnostics. Contrast agents expand the range of tasks that ultrasound can perform. In the clinic in US, endocardial border delineation and left ventricle opacification have been an approved indication for more than a decade. However, myocardial perfusion contrast ultrasound studies are still at the clinical trials stage. Blood pool contrast and perfusion in other tissues might be an easier indication to achieve: general blood pool ultrasound contrast is in wider use in Europe, Canada, Japan, and China. Targeted (molecular) contrast microbubbles will be the next generation of ultrasound imaging probes, capable of specific delineation of the areas of disease by adherence to molecular targets. The shell of targeted microbubbles (currently in the preclinical research and early stage clinical trials) is decorated with the ligands (antibodies, peptides or mimetics, hormones, carbohydrates) that ensure firm binding to the molecular markers of disease.

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“…With the recent advancement of echocardiographic contrast agent [11,12], myocardial contrast echocardiography (MCE) became one of the established methods to evaluate myocardial perfusion [13,14], however, its usefulness in small animal model is not clarified.…”

Section: Introductionmentioning

confidence: 99%

Quantitative assessment of infarct size in vivo by myocardial contrast echocardiography in a murine acute myocardial infarction model

Park

Lee

Park

et al. 2004

International Journal of Cardiology

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Myocardial imaging with a new transpulmonary lipid-fluorocarbon echo contrast agent: Experimental studies in pigs

Cited by 28 publications

References 38 publications

Contrast-Enhanced Diagnostic Ultrasound Causes Renal Tissue Damage in a Porcine Model

Contrast-Enhanced Diagnostic Ultrasound Causes Renal Tissue Damage in a Porcine Model

Ultrasound Contrast Materials in Cardiovascular Medicine: from Perfusion Assessment to Molecular Imaging

Quantitative assessment of infarct size in vivo by myocardial contrast echocardiography in a murine acute myocardial infarction model

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