2015
DOI: 10.1016/j.jpeds.2015.06.001
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Myocardial Ischemia Secondary to Synthetic Cannabinoid (K2) Use in Pediatric Patients

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Cited by 43 publications
(30 citation statements)
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“…Based on the rising misuse of synthetic cannabinoids in humans and the associated risk of toxic exposure (Clark et al, 2015; Hermanns-Clausen et al, 2013; Ibrahim et al, 2014; Mir et al, 2011; Shah et al, 2016; Young et al, 2012), there is clearly a need for basic research investigating the physiological effects of these compounds. Although many synthetic cannabinoids induce effects that are similar to THC, their greater potency may lead to an increased propensity for adverse effects when these compounds are misused as substitutes for THC.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Based on the rising misuse of synthetic cannabinoids in humans and the associated risk of toxic exposure (Clark et al, 2015; Hermanns-Clausen et al, 2013; Ibrahim et al, 2014; Mir et al, 2011; Shah et al, 2016; Young et al, 2012), there is clearly a need for basic research investigating the physiological effects of these compounds. Although many synthetic cannabinoids induce effects that are similar to THC, their greater potency may lead to an increased propensity for adverse effects when these compounds are misused as substitutes for THC.…”
Section: Discussionmentioning
confidence: 99%
“…Given the recent rise in toxic exposures to synthetic cannabinoids (Clark et al, 2015; Hermanns-Clausen et al, 2013; Ibrahim et al, 2014; Mir et al, 2011; Shah et al, 2016; Young et al, 2012), it is important to further investigate the physiological effects of these compounds. Here, we used biotelemetry in male Sprague-Dawley rats to examine the effects of THC and the synthetic cannabinoids JWH-018, AM2201, XLR-11, and CP55,940 (a well-established reference cannabinoid agonist used in preclinical experiments) on body temperature and cardiovascular parameters.…”
Section: Introductionmentioning
confidence: 99%
“…Some users reported and/or showed additional unique effects from SCs such as agitation [27], hypokalaemia, hyperglycemia, seizures and emesis [29,30], acute kidney injury [31], stroke [32], myocardial ischemia secondary [33] and myocardial infarction [34]. SCs have also been reported in association with deaths in several publications.…”
Section: Pharmacological and Toxicological Aspects Of Synthetic Cannamentioning
confidence: 99%
“…6 Drugs found in this class include antihistamines, antispasmotics, atropine, antiparkinson drugs, antipsychotics, antidepressants, and phenothiazines. 7 A general approach to the patient with these exposures involves maintaining an airway, correct hypotension with IV fluid boluses, benzodiazepines, antipyretics, and physostigmine for seizures or resistant dysrhythmias. 6 Cholinergic As expected, the cholinergic toxidrome is the opposite presentation of the anticholinergic toxidrome.…”
Section: Anticholinergic (Antimuscarinic)mentioning
confidence: 99%
“…34,37 A lesser known effect of THC is its ability to increase sympathetic activity and inhibit parasympathetic activity, which explains why SCBs can cause tachycardia, hypertension, and other stimulating effects. 7 Management of an exposure often only requires supportive care, but if the patient is experiencing significant side effects related to the sympathomimetic effects, then management of intoxication is indicated. 37…”
Section: Synthetic Cannabinoidsmentioning
confidence: 99%