Myocardial preservation using celsior solution in cardiac transplantation: early results and 5-year follow-up of a multicenter prospective study of 70 cardiac transplantations

Ischemically Damaged Heart After Preservation by the Cavitary Two-layer Method as a Possible Donor in Rat Heart Transplantation

“…In UW cold storage, mitochondrial damage may result from the accumulation of fatty acids and molecular damage to ATP synthase, which is essential in ATP synthesis. 20 On the other hand, the present study demonstrated that…”

A Comparative Prospective Study of Two Available Solutions for Kidney and Liver Preservation

“…Advances in immunosuppressive therapy have substantially reduced the severity and rate of acute rejection and improved short-and long-term clinical outcomes for renal transplantation (4). However, despite a high 1-year graft survival rate, long-term graft survival has not improved substantially (5).…”

“…The disadvantages of the UW use are high viscosity, which may prolong perfusion time, and high price (2). Celsior (CEL) (Sangstat Medical, Menlo Park, CA) is a new extracellular-type, low-potassium, low-viscosity preservation solution that was initially used for heart and lung preservation (3,4) and more recently proposed for the abdominal setting. CEL substantially differs from UW in electrolytic composition and in osmotic agent contents (mannitol replaces hydroxyethyl starch).…”

Evidence for a Mitochondrial Impact of Trimetazidine during Cold Ischemia and Reperfusion

“…Recent solutions using high Na + and low K + ratio were successfully assessed in multi-organ preservation. CEL was recently developed as a multi-organ preservation solution [18][19][20]. The high Na + -low K + version of UW was also evaluated in different preservation conditions [21,22].…”