Myocardial T1 values in healthy volunteers measured with saturation method using adaptive recovery times for T1 mapping (SMART1Map) at 1.5 T and 3 T

Matsumoto, Shunsuke; Okuda, S.; Yamada, Yoshitake; Suzuki, Tomohiko; Tanimoto, Akihiro; Nozaki, Atsushi; Jinzaki, Masahiro

doi:10.1007/s00380-019-01401-5

Cited by 9 publications

(12 citation statements)

References 28 publications

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“…The precursor sequence to Smart1Map, MLLSR, had yielded much lower native T 1 values of 910 ± 93 msec in adults on a 1.5T scanner, most likely because it still used several acquisitions after each saturation pulse, thereby altering T 1 relaxation similarly to MOLLI. Using Smart1Map with only one acquisition per saturation pulse, however, adult normal myocardial native T 1 values have been reported as identical to our pediatric native T 1 values with a mean of 1193 msec at 1.5T or slightly higher with a mean of 1227 msec, which could be due to different patient selections …”

Section: Discussionsupporting

confidence: 47%

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Burkhardt

Menghini

Rücker

et al. 2019

Magnetic Resonance Imaging

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Background T1 mapping is useful to quantify diffuse myocardial processes such as fibrosis, edema, storage disorders, or hemochromatosis. Normal pediatric myocardial T1 values are scarce using modified Look–Locker inversion recovery (MOLLI) sequences and unavailable using Smart1Map, a single‐point saturation recovery sequence that measures true T1. Purpose/Hypothesis To establish normal pediatric myocardial T1 values by Smart1Map and to compare them with T1 by MOLLI. Study Type Prospective cohort study. Subjects Thirty‐four children and adolescents aged 8–18 years (14 males) without cardiovascular or inflammatory diseases. Field Strength/Sequences 1.5T, MOLLI, Smart1Map. Assessment Mean T1 values of the left ventricular myocardium, the interventricular septum, and the blood pool were measured with MOLLI and Smart1Map in basal, mid‐ventricular, and apical short axis slices. Statistical Tests T1 values were compared between locations and methods by paired samples t‐tests, Wilcoxon signed ranks test, repeated‐measures analysis of variance (ANOVA), or Friedman's test. Pearson's correlation coefficient was calculated. For interobserver variability, intraclass correlation coefficients and coefficients of variation were calculated, and Bland–Altman analyses were performed. Results T1 values were longer by Smart1Map than by MOLLI in all measured locations (myocardium: 1191–1221 vs. 990–1042 msec; all P < 0.001). T1 in basal vs. mid‐ventricular slices differed both by MOLLI and by Smart1Map for myocardium and for blood (all P < 0.001). Myocardial T1 did not correlate with age, heart rate, right or left ventricular ejection fraction (all P > 0.05) by either method. Septal vs. total myocardial T1 values in each slice did not differ by MOLLI (basal P = 0.371; mid‐ventricular P = 0.08; apical P = 0.378) nor by Smart1Map (basal P = 0.056; mid‐ventricular P = 0.918; apical P = 0. 392), after artifacts had been carefully excluded. Data Conclusion We established pediatric normal native T1 values using the Smart1Map sequence and compared the results with T1 mapping with MOLLI. Septal T1 values did not differ from total myocardial T1 values in each of the myocardial slices. Level of Evidence: 2 Technical Efficacy: Stage 2 J. Magn. Reson. Imaging 2020;51:897–903.

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Section: Discussionsupporting

confidence: 47%

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Burkhardt

Menghini

Rücker

et al. 2019

Magnetic Resonance Imaging

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“…This study is also the first one published using the SMART 1 Map sequence for the assessment of T 1 mapping in patients. Matsumoto et al 21 described the reference range of native T 1 values using the SMART 1 Map sequence in 24 healthy volunteers. Similarly, Burkhardt et al 20 established paediatric normal native T 1 values using the SMART 1 Map sequence.…”

Section: Discussionmentioning

confidence: 99%

Myocardial T₁ mapping using SMART₁Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis

et al. 2020

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Introduction: Sarcoidosis is a systemic granulomatous disease affecting in particular the respiratory tract. Cardiac magnetic resonance (CMR), including a measurement of T 1 relaxation time, could potentially detect early stadia of sarcoidosis of the heart. The study aims to assess T 1 mapping in the detection of early cardiac involvement in asymptomatic patients with sarcoidosis. Methods: One hundred and twenty patients with extracardiac sarcoidosis and without any heart disease history were included. One hundred and thirteen of them underwent a CMR examination. The mean time from the diagnosis of sarcoidosis was 0.8 (0.2-3.3) years. Cine images for the assessment of left ventricular (LV) functional parameters and pre-and post-contrast saturation method using adaptive recovery times for cardiac T 1 mapping (SMART 1 Map) and modified Look-Locker inversion recovery (MOLLI) images were acquired for the assessment of native T 1 relaxation time and extracellular volume (ECV). The measured parameters were compared between sarcoidosis patients and 22 controls. Results: The sarcoidosis patients had normal global and regional systolic LV function-LV ejection fraction 65 ± 5% versus 66 ± 7% (p NS). The mean native T 1 relaxation times were not prolonged-1465 ± 93 ms versus 1480 ± 88 ms (p NS) measured by SMART 1 Map and 1317 ± 60 ms versus 1313 ± 83 ms (p NS) measured using a MOLLI sequence. Similarly, the mean ECV values did not increase-16.9 ± 3.9% versus 17.9 ± 3.7% (p NS) measured by SMART 1 Map and 30.9 ± 2.9% versus 31.6 ± 8.3% (p NS) measured using a MOLLI sequence. Conclusion: Myocardial native T 1 relaxation times were not prolonged and ECV was not increased in asymptomatic patients with extracardiac sarcoidosis.

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“…The saturation recovery T1 mapping sequence used in this study, SMART1Map, measures the true T1 value and is less sensitive to imaging and physiologic parameters ( 11 , 14 , 15 ). As a result, SMART1Map native T1 values are longer than those obtained by using a modified Look-Locker inversion recovery sequence ( 10 , 14 – 16 ). The native T1 values in the control participants of this study, 1423 msec ± 70, are within the same range as those reported by Ferry et al ( 15 ), 1447 msec ± 45, who used the same single-point saturation recovery T1 mapping sequence at 3 T.…”

Section: Discussionmentioning

confidence: 90%

“…Non–contrast-enhanced CMR was performed with a 3.0-T combined PET/MR imager (GE Signa PET/MR Discovery 750 W; GE Healthcare) ( 3 ). Native T1 mapping was assessed by using a single, short-axis, mid-LV section with a single-point saturation recovery sequence (saturation method using adaptive recovery times for T1 mapping [SMART1Map; GE Healthcare]) ( 10 , 11 ). Parameters for T1 mapping were 3.1-msec repetition time, 1.0-msec echo time, 350 × 350–mm 2 field of view, 1.4 × 1.4–mm 2 in-plane spatial resolution, and 7-mm section thickness.…”

Section: Methodsmentioning

confidence: 99%

Diffuse Myocardial Fibrosis at Cardiac MRI in Young Adults Born Prematurely: A Cross-sectional Cohort Study

François¹,

Barton²,

Corrado³

et al. 2022

Radiology: Cardiothoracic Imaging

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Purpose To measure native T1 values, a marker of diffuse fibrosis, by using cardiac MRI (CMR) in young adults born prematurely. Materials and Methods This secondary analysis of a prospective cohort study included young adults born moderately to extremely preterm and age-matched, term-born participants. CMR was performed with a 3.0-T imager that included cine imaging for the quantification of left ventricular (LV) and right ventricular (RV) volumes and function and native saturation recovery T1 mapping for the assessment of diffuse myocardial fibrosis. Values between preterm and term were compared by using the Student t test. Associations between T1 values and other variables were analyzed by using linear regression and multivariate regression. Results Of the 50 young-adult participants, 32 were born preterm (mean age, 25.8 years ± 4.2 [SD]; 23 women) and 18 were born at term (mean age, 26.2 years ± 5.4; 10 women). Native T1 values were significantly higher in participants born preterm than in participants born at term (1477 msec ± 77 vs 1423 msec ± 71, respectively; unadjusted P = .0019). Native T1 values appeared to be positively associated with indexed LV end-diastolic and end-systolic volumes (β = 2.1, standard error = 0.7 and β = 3.8, standard error = 1.2, respectively), the RV end-diastolic volume index (β = 1.3, standard error = 0.6), and the LV mass index (β = 2.5, standard error = 0.9). Higher T1 values may be associated with reduced cardiac systolic strain measures and diastolic strain measures. Five-minute Apgar scores were inversely associated with native T1 values. Conclusion Young adults born moderately to extremely preterm exhibited significantly higher native T1 values than age-matched, term-born young adults. Keywords: MRI, Cardiac, Heart, Left Ventricle, Cardiomyopathies Clinical trial registration no. NCT03245723 Published under a CC BY 4.0 license Supplemental material is available for this article.

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Myocardial T1 values in healthy volunteers measured with saturation method using adaptive recovery times for T1 mapping (SMART1Map) at 1.5 T and 3 T

Cited by 9 publications

References 28 publications

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Myocardial T₁ mapping using SMART₁Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis

Diffuse Myocardial Fibrosis at Cardiac MRI in Young Adults Born Prematurely: A Cross-sectional Cohort Study

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Myocardial T1 values in healthy volunteers measured with saturation method using adaptive recovery times for T1 mapping (SMART1Map) at 1.5 T and 3 T

Cited by 9 publications

References 28 publications

Normal myocardial native T1 values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Normal myocardial native T1 values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Myocardial T1 mapping using SMART1Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis

Diffuse Myocardial Fibrosis at Cardiac MRI in Young Adults Born Prematurely: A Cross-sectional Cohort Study

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Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Normal myocardial native T₁ values in children using single‐point saturation recovery and modified look–locker inversion recovery (MOLLI)

Myocardial T₁ mapping using SMART₁Map and MOLLI mapping in asymptomatic patients with recent extracardiac sarcoidosis