Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep

Abstract

. Myocardial vascular and metabolic adaptations in chronically anemic fetal sheep.

Circulating N-terminal pro-B-type natriuretic peptide in fetal anemia before and after treatment

“…Adaptive cardiac mechanisms to chronic anemia have been investigated in animals. Chronically anemic sheep fetuses show increases in myocardial mass and vascularization as well as changes in the expression of various angiogenic, hypoxia-related, and glycolytic genes (25,26). Furthermore, cardiac remodeling induced by chronic intrauterine anemia results in increased contractile response and coronary conductance in adult animals (27,28).…”

Sensory quality of meat from eight different types of cattle in relation with their biochemical characteristics

“…representative of different steps of the glycolytic and oxidative pathways are currently used for 356 the characterization of the metabolic types of muscles in beef (Sudre et al 2005;Jurie et al 357 2006), poultry (Eadmusik et al 2011), pig (Demars et al 2007), sheep (Mascio et al 2005) 358 and camel (Abdelhadi et al 2012;Al-Owaimer et al 2014) …”

Chronic hypoxia increases peroxynitrite, MMP9 expression, and collagen accumulation in fetal guinea pig hearts

“…This condition can result from several pregnancyrelated complications such as maternal illness, placental insufficiency, and living at high altitude, resulting in reduced oxygenation of the fetus (8)(9)(10). Prolonged exposure to a hypoxic (HPX) environment can result in intrauterine growth restriction, a leading cause of fetal morbidity and mortality (11), and organ-specific pathologies of the heart (e.g., myocardial hypertrophy) and brain (e.g., severe gliosis in the cerebral cortex and decreased myelination) (11,12).…”