Myocarditis Caused by <i>Brucella melitensis</i> in the Absence of Endocarditis: Case Report and Review of the Literature

Lagadinou, Maria; Mplani, Virginia; Velissaris, Dimitrios; Davlouros, Periklis; Marangos, Markos

doi:10.1155/2019/3701016

Cited by 8 publications

(8 citation statements)

References 13 publications

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“…The symptoms of productive cough and dyspnoea appear to be common in patients with pulmonary involvement, 11,12 and chest pain is typical in cardiac involvement. 13,14 Clinicians should remain aware of these symptoms, as such awareness may prevent serious disorders. Diagnosis of brucellosis requires isolating the organisms from blood or body tissues, or combining the suggestive clinical presentations and positive serology.…”

Section: Discussionmentioning

confidence: 99%

A case report of rare complication of brucellosis infection: myocarditis and pneumonitis

He¹,

Wei²,

Yun³

et al. 2023

J Int Med Res

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The involvement of cardiovascular or respiratory complications in cases of brucellosis are extremely rare. Herein, a case of myocarditis and pneumonia with pericardial effusion, pleural effusion and biliteral pleural thickening with pleural adhesion in a 35-year-old female patient, is described. Using next-generation sequencing, the patient was differentially diagnosed with Brucella-related myocarditis and pneumonitis, and treatment with oral doxycycline, rifampicin, and trimethoprim/sulfamethoxazole, along with intravenous gentamycin, was commenced. Following treatment, the patient was clinically improved. When a patient with brucellosis presents with chest pain, clinicians should be aware of this clinical manifestation. Next-generation sequencing may be used to identify pathogens and provide insights into the disease when appropriate cultures are negative.

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Section: Discussionmentioning

confidence: 99%

A case report of rare complication of brucellosis infection: myocarditis and pneumonitis

He¹,

Wei²,

Yun³

et al. 2023

J Int Med Res

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“…Myocarditis secondary to brucella infection was also reported very recently in a 21-year-old Caucasian man who was admitted with complaints of fever, fatigue, and retrosternal pain. His ECG showed ST elevation in I, II, aVL, and V4-V6, and echocardiography showed wall motion abnormalities [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

A Rare Presentation of Brucellosis as Myocarditis

Bhatty

Kumar

Javed

et al. 2020

Cureus

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Brucellosis is commonly transmitted by consumption of unpasteurized dairy products and most commonly presents as fever, arthralgia, fatigue, hepatosplenomegaly, and peripheral arthritis. Our patient presented with a history of three months of high-grade fever, undocumented significant weight loss, jaundice, and hepatosplenomegaly. On the seventh day of admission, he developed sudden onset of shortness of breath, and his jugular venous pressure was raised with fine crackles at the lung bases bilaterally and pedal edema up to the ankles bilaterally. Electrocardiography was done, which showed T wave inversions in 1 and augmented Vector Left (aVL). Troponin I was raised at that time, and echocardiography revealed an ejection fraction of 40%. A diagnosis of myocarditis secondary to brucellosis was made.

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“…In more severe, active infections, there was both endocarditis and epicarditis with histiocytic and suppurative inflammation. Brucella myocarditis in dolphins could be similar to humans with Brucella infections in which endocarditis has been implicated in death (Jeroudi et al 1987, Abid et al 2012, Lagadinou et al 2019. B. ceti has been isolated from a dolphin with a vegetative endocarditis lesion (González-Barrientos et al 2010).…”

Section: Additional Lesions and B Cetimentioning

confidence: 99%

Brucella ceti sequence type 23, 26, and 27 infections in North American cetaceans

et al. 2022

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Brucella ceti infection is associated with a variety of disease outcomes in cetaceans globally. Multiple genotypes of B. ceti have been identified. This retrospective aimed to determine if specific lesions were associated with different B. ceti DNA sequence types (STs). Characterization of ST was performed on 163 samples from 88 free-ranging cetaceans, including common bottlenose dolphin Tursiops truncatus (T.t.; n = 73), common short-beaked dolphin Delphinus delphis (D.d.; n = 7), striped dolphin Stenella coeruleoalba (n = 3), Pacific white-sided dolphin Lagenorhynchus obliquidens (n = 2), sperm whale Physeter macrocephalus (n = 2), and harbour porpoise Phocoena phocoena (n = 1), that stranded along the coast of the US mainland and Hawaii. ST was determined using a previously described insertion sequence 711 quantitative PCR. Concordance with 9-locus multi-locus sequence typing was assessed in a subset of samples (n = 18). ST 26 was most commonly identified in adult dolphins along the US east coast with non-suppurative meningoencephalitis (p = 0.009). Animals infected with ST 27 were predominately perinates that were aborted or died shortly after birth with evidence of in utero pneumonia (p = 0.035). Reproductive tract inflammation and meningoencephalitis were also observed in adult T.t. and D.d. with ST 27, though low sample size limited interpretation. ST 23 infections can cause disease in cetacean families other than porpoises (Phocoenidae), including neurobrucellosis in D.d. In total, 11 animals were potentially infected with multiple STs. These data indicate differences in pathogenesis among B. ceti STs in free-ranging cetaceans, and infection with multiple STs is possible.

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Myocarditis Caused by Brucella melitensis in the Absence of Endocarditis: Case Report and Review of the Literature

Cited by 8 publications

References 13 publications

A case report of rare complication of brucellosis infection: myocarditis and pneumonitis

A case report of rare complication of brucellosis infection: myocarditis and pneumonitis

A Rare Presentation of Brucellosis as Myocarditis

Brucella ceti sequence type 23, 26, and 27 infections in North American cetaceans

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