Myocarditis Following COVID-19 Vaccination

Marschner, Constantin; Shaw, Kirsten E.; Tijmes, Felipe Sánchez; Fronza, Matteo; Khullar, Sharmila; Seidman, Michael A.; Thavendiranathan, Paaladinesh; Udell, Jacob A.; Wald, Rachel M.; Hanneman, Kate

doi:10.1016/j.ccl.2022.05.002

Cited by 11 publications

(12 citation statements)

References 69 publications

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“…Myocarditis is an infrequent adverse event following administration of messenger RNA (mRNA) based COVID-19 vaccines, with highest risk in adolescent and young adult men. 66 The pattern of myocardial injury in patients with myocarditis after COVID-19 vaccination is similar to other causes of myocarditis, but typically with less severity. 67,68 A small case series demonstrated resolution of myocardial edema, normalization of left ventricular function and interval decrease in LGE extent at intermediate term follow-up (median 159 days).…”

Section: Covid-19 Vaccine-related Myocarditismentioning

confidence: 95%

Cardiac Imaging in Myocarditis: Current Evidence and Future Directions

et al. 2022

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Myocarditis is defined as a non-ischemic inflammatory disease of the myocardium. It remains a challenge to diagnose given non-specific symptoms and lack of specific blood biomarkers. Cardiac imaging plays an important role in the evaluation of myocarditis with unique strengths and limitations of different imaging modalities, including cardiac magnetic resonance imaging, echocardiography, cardiac computed tomography, and positron emission tomography. The purpose of this review is to discuss the strengths and limitations of various cardiac imaging techniques in the evaluation of myocarditis, review imaging findings in specific causes of myocarditis including COVID-19 and after vaccination, evaluate the role of imaging in differentiating myocarditis from potential mimics and differential considerations, identify current gaps in knowledge, and propose future directions.

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Section: Covid-19 Vaccine-related Myocarditismentioning

confidence: 95%

Cardiac Imaging in Myocarditis: Current Evidence and Future Directions

et al. 2022

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“…90,91 Myocarditis Following COVID-19 Vaccination Following a global COVID-19 vaccination campaign, there were early reports of myocarditis following administration of messenger RNA (mRNA) based COVID-19 vaccines. 92 The risk is highest in adolescent and young adult males between 12 and 40 years of age following the second dose, with lower incidence following the first dose and third or subsequent doses. 93 The pattern of myocardial injury on MRI is similar to other causes of myocarditis, but typically with less severe abnormalities.…”

Section: Multisystem Inflammatory Syndrome In Childrenmentioning

confidence: 99%

“…Following a global COVID‐19 vaccination campaign, there were early reports of myocarditis following administration of messenger RNA (mRNA) based COVID‐19 vaccines 92 . The risk is highest in adolescent and young adult males between 12 and 40 years of age following the second dose, with lower incidence following the first dose and third or subsequent doses 93 .…”

Section: Myocarditis Following Covid‐19 Vaccinationmentioning

confidence: 99%

Magnetic Resonance Imaging of Cardiovascular Manifestations Following COVID‐19

Tijmes

Marschner

Thavendiranathan

et al. 2023

Magnetic Resonance Imaging

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Globally, over 650 million people have had COVID‐19 due to infection with the SARS‐Cov‐2 virus. Cardiac complications in the acute infectious and early recovery phase were recognized early in the pandemic, including myocardial injury and inflammation. With a decrease in the number of acute COVID‐19 related deaths, there has been increased interest in postacute sequela of COVID‐19 (PASC) and other longer‐term cardiovascular complications. A proportion of patients recovered from COVID‐19 have persistent cardiac symptoms and are at risk of cardiovascular disease. Cardiovascular imaging, including MRI, plays an important role in the detection of cardiovascular manifestations of COVID‐19 in both the acute and longer‐term phases after COVID‐19. The purpose of this review is to highlight the role of cardiovascular imaging in the diagnosis and risk stratification of patients with acute and chronic cardiovascular manifestations of COVID‐19 with a focus on cardiac MRI. Evidence Level 4. Technical Efficacy Stage 3.

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“…In the setting of suspected myocarditis, the revised Lake Louise Criteria (LLC) are typically used for evaluation of cardiac MRI findings. 2 Several recent case series have described cardiac MRI findings in patients with myocarditis following COVID‐19 vaccination. 3 , 4 However, these are limited by relatively small sample sizes.…”

mentioning

confidence: 99%

“…Cardiac MRI plays an important role in the assessment of acute myocarditis with unparalleled ability for noninvasive characterization of myocardial tissue. In the setting of suspected myocarditis, the revised Lake Louise Criteria (LLC) are typically used for evaluation of cardiac MRI findings 2 . Several recent case series have described cardiac MRI findings in patients with myocarditis following COVID‐19 vaccination 3,4 .…”

mentioning

confidence: 99%