Myoclonus in guinea pigs is induced by indole-containing but not piperazine-containing 5HT agonists

Luscombe, Graham; Jenner, Peter; Marsden, C. D.

doi:10.1016/0024-3205(82)90563-x

Cited by 21 publications

(3 citation statements)

References 24 publications

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“…Differentiation between 5-HTA and 5-HT,B subtypes have also been demonstrated in recent behavioural studies. Indoletype 5-HT agonists such as 5-MeODMT produce the 5-HT behavioural syndrome in rats (Sills et al, 1985) and myoclonus in guinea-pigs (Luscombe et al, 1982), whereas the piperazine-type agonists such as m-CPP do not produce this syndrome. The present study further suggests that 5-HT receptors of the 5-HTB subtype may become supersensitive after long-term treatment with the antidepressant drug imipramine.…”

Section: Discussionmentioning

confidence: 96%

Long‐term imipramine treatment enhances locomotor and food intake suppressant effects of m‐chlorophenylpiperazine in rats

Aulakh

Cohen

Hill

et al. 1987

British J Pharmacology

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1 Administration of the 5-HTIB receptor agonist m-chlorophenylpiperazine (m-CPP) to rats produces dose-dependent decreases in locomotor activity and food intake. 2 The locomotor suppressant effect of m-CPP was inhibited by the 5-hydroxytryptaminergic antagonist, metergoline, but not by phentolamine, propranolol, clonidine, or haloperidol. 4 The food intake suppressant effects of m-CPP were enhanced following both short (3-5 days) and longer-term (21 days) treatment with imipramine. Rapidly developing 5-hydroxytryptamine uptake inhibition may be responsible for this change, or it may represent an earlier adaptive change in the 5-HTIB receptors mediating food intake compared to more complexly modulated motor responses.

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Section: Discussionmentioning

confidence: 96%

Long‐term imipramine treatment enhances locomotor and food intake suppressant effects of m‐chlorophenylpiperazine in rats

Aulakh

Cohen

Hill

et al. 1987

British J Pharmacology

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“…The behavioural effects of these compounds have been extensively studied (Gessner and Page, 1962: havioural studies in guinea pigs (Luscombe et al, 1982) and rats (Vetulani et al, 1979).…”

Section: Discussionmentioning

confidence: 99%

“…However, there are some interesting differences between the actions of indoleamine-and piperazinecontaining compounds. It was found, for example, that indoleaminebut not piperazine-containing 5-HT agonists produced myoclonus in guinea pigs (Luscombe et al, 1982). LSD and 5-MeODMT have also been shown to decrease the firing rate of the dorsal raphe nucleus (Haigler and Aghajanian, 1974;Rogawski and Aghajanian, 1981) and to stim-ulate 5-HT-sensitive adenylate cyclase Won Hungen e t al., 1975).…”

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confidence: 99%

Local Cerebral Glucose Utilisation Following Indoleamine‐ and Piperazine‐Containing 5‐Hydroxytryptamine Agonists

1986

Journal of Neurochemistry

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Substances with varying structural components have been shown to have 5-hydroxytryptamine (5-HT)-like properties in the CNS. In this study, putative 5-HT agonists with indoleamine moeities--lysergic acid diethylamide (LSD) and 5-methoxy-N,N-dimethyltryptamine (5-MeODMT)--and with piperazine moieties--quipazine (Quip) and 6-chloro-2-(1-piperazinyl)pyrazine (6-CPP) were administered to rats. Local cerebral glucose utilisation was measured using the [14C]2-deoxyglucose autoradiographic technique. It was found that in most cerebral structures, these substances produced dose-dependent reductions in glucose utilisation. However, Quip and 6-CPP increased glucose utilisation in specific areas of the diencephalon (e.g., nucleus reuniens) and produced a biphasic effect in some but not all extrapyramidal structures (e.g., ventromedial caudate nucleus). No such increases in local cerebral glucose utilisation were measured following LSD or 5-MeODMT administration. These results indicate that although similarities exist between the effects of indoleamine- and piperazine-containing 5-HT agonists on local cerebral glucose utilisation there are also significant differences in the overall patterns of response produced.

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Brain 5-hydroxytryptamine level, metabolism, and binding in E1 mice

Hiramatsu

1983

Neurochem Res

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Inbred E1 mice are highly susceptible to convulsive seizures upon "throwing" stimulation. The strain is known to have an abnormal 5-hydroxytryptamine (5-HT) metabolism. In the study here 5-HT level, [14C]5-hydroxytryptophan (5-HTP) metabolism, MAO activity and [3H]5-HT receptor binding were examined in the cortex, brainstem and cerebellum. In the interictal period cortical and brainstem 5-HT level and [3H]5-HT receptor binding were significantly lower. In the same period cortical biosynthesized [14C]5-HT from [14C]5-HTP taken up was higher, and MAO activity was not changed. L-DOPA with MK486 induced a low threshold of seizures and decreased cortical 5-HT level. Abnormally functioning 5-HT neurones may exist in the E1 mouse cortex.

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Myoclonus in guinea pigs is induced by indole-containing but not piperazine-containing 5HT agonists

Cited by 21 publications

References 24 publications

Long‐term imipramine treatment enhances locomotor and food intake suppressant effects of m‐chlorophenylpiperazine in rats

Long‐term imipramine treatment enhances locomotor and food intake suppressant effects of m‐chlorophenylpiperazine in rats

Local Cerebral Glucose Utilisation Following Indoleamine‐ and Piperazine‐Containing 5‐Hydroxytryptamine Agonists

Brain 5-hydroxytryptamine level, metabolism, and binding in E1 mice

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