2012
DOI: 10.1016/j.gene.2012.04.004
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Myocyte enhancer factor-2 and cardiac muscle gene expression during hibernation in thirteen-lined ground squirrels

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Cited by 35 publications
(25 citation statements)
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“…In D. melanogaster, miR-92b also regulates the expression of Mef2, a key transcription factor involved in muscle development [8]. Mef2 expression has yet to be characterized in E. solidaginis, but studies performed with cardiac and skeletal muscle from hibernating I. tridecemlineatus showed differential expression of this factor during torpor [48,49]. Results in the present study also show miR-92b down-regulation in anoxic E. solidaginis.…”
Section: Discussionsupporting
confidence: 52%
“…In D. melanogaster, miR-92b also regulates the expression of Mef2, a key transcription factor involved in muscle development [8]. Mef2 expression has yet to be characterized in E. solidaginis, but studies performed with cardiac and skeletal muscle from hibernating I. tridecemlineatus showed differential expression of this factor during torpor [48,49]. Results in the present study also show miR-92b down-regulation in anoxic E. solidaginis.…”
Section: Discussionsupporting
confidence: 52%
“…During mammal hibernation, cardiac hypertrophy increases contractile strength [15,72]. Unlike hypertrophic cardiomyopathy disease in humans, cardiac hypertrophy in hibernators is beneficial and quickly reversed upon arousal [72]. The cardiac-specific transcription factors with increased expression during bearded dragon hibernation ( Fig.…”
Section: Response To Cellular Stressmentioning
confidence: 99%
“…The changes experienced by the heart during progression to pathological hypertrophy include hardening of atrial walls, decreases in blood diastolic volume, and decreases in perfusion efficiency [15]. Although reversible cardiac hypertrophy is observed in the hearts of hibernators, the molecular mechanisms by which this occurs are only beginning to be elucidated [18][19][20][21][22]. The present study focuses on GATA4 and Nkx2-5 transcription factors and downstream genes which have been shown to play a role in attenuating damage caused by cardiac hypertrophy or cytotoxic stress.…”
Section: Introductionmentioning
confidence: 99%