2010
DOI: 10.1161/circresaha.110.231498
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Myocyte Turnover in the Aging Human Heart

Abstract: Rationale:The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology.Objective: The effects of age and gender on the magnitude of myocyte regeneration and the origin of newly formed cardiomyocytes were determined. Methods and Results:The interaction of myocyte replacement, cellular senescence, growth inhibition, and apoptosis was measured in normal female (n‫)23؍‬ and male (n‫)24؍‬ human hearts collected from patients 19 to 10… Show more

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Cited by 259 publications
(241 citation statements)
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“…45 Self-renewal is critical to maintain myocyte number in the face of continuous loss from even low rates of apoptosis. 46 Other studies support the notion that BMPCs can populate the heart and adopt a cardiomyogenic phenotype as a source of myocyte renewal. 47 The present results indicate that icMSCs are capable of increasing the cKit ϩ / CD133 ϩ progenitor cell pool and, in contrast to MSCs administered via intramyocardial injection, do so throughout the entire heart.…”
Section: Sources Of New Cardiomyocytes and Myocyte Turnovermentioning
confidence: 87%
“…45 Self-renewal is critical to maintain myocyte number in the face of continuous loss from even low rates of apoptosis. 46 Other studies support the notion that BMPCs can populate the heart and adopt a cardiomyogenic phenotype as a source of myocyte renewal. 47 The present results indicate that icMSCs are capable of increasing the cKit ϩ / CD133 ϩ progenitor cell pool and, in contrast to MSCs administered via intramyocardial injection, do so throughout the entire heart.…”
Section: Sources Of New Cardiomyocytes and Myocyte Turnovermentioning
confidence: 87%
“…The potential of CPCs to renew cardiac tissue in the course of individual life was confirmed in 2009-2010, when it was shown that cardiomyocytes in adult human organisms were renewed at a rate of about 1% per year at the age of 25, decreasing to 0.45% at the age of 75 [34,35]. The process apparently continues into advanced age, as functional cardiac progenitor cells have been found in hearts of individuals aged >90 [35]. According to the calculations made by the authors, about 50% of cardiomyocytes were effectively replaced in the course of the average human lifespan.…”
Section: Adult Cardiac Progenitor Cellsmentioning
confidence: 95%
“…Cultured cardiomyocyte progenitors (cardiac progenitor cells, vascular stem cells) and cardiomyocytes derived from pluripotent cells could be maintained in vitro for years, and, potentially, for decades. Unlike differentiated adult cardiomyocytes that are replaced (albeit at a rate of 5-10 % per decade), cardiomyocyte progenitors were programmed to last throughout a normal human life, as they have been found in hearts of nonagenarians Cardiomyocytes derived from stem cells [35]. Thus, cultured cardiac cells may be preferable to living animals as research models, despite the levels of integration and complexity that animals may offer.…”
Section: The Methuselah Of Mice -Modelling Reliably Common Multifactomentioning
confidence: 99%
“…24) The relative proportion of Ki67-positive and Ki67-negative EPCs was measured quantitatively. Moreover, the fraction of EPCs with nuclei stained by the terminal deoxynucleotidyltransferase (TdT)-mediated dUTP nick-end labeling (TUNEL) assay was employed to detect cell apoptosis (ApoAlert DNA fragmentation kit, Clontech).…”
Section: )mentioning
confidence: 99%