Myoepithelioma of the Parotid Gland: A Case Report with Review of the Literature and Classic Histopathology

Weitzel, Mark; Cohn, Jason E.; Spector, Harvey

doi:10.1155/2017/6036179

Cited by 18 publications

(41 citation statements)

References 16 publications

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“…Myoepithelioma is a tumor that differentiates toward myoepithelial cells, which are mostly found in the salivary gland [2,3]. Similar to their salivary gland counterparts, myoepithelial tumors of soft tissues are rare and have heterogeneous morphologic and immunophenotypic features [3].…”

Section: Discussionmentioning

confidence: 99%

Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor

et al. 2020

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Objective: Rare disease Background: Myoepithelioma is a rare neoplasm that differentiates toward myoepithelial cells. This condition mainly occurs in the salivary gland and rarely in the soft tissue or internal organs. Long-term survival with repeated multiple rounds of resection for recurrence is rarely reported. Case Report: A 69-year-old man was diagnosed with metachronous pancreatic and thyroid metastases from myoepithelioma, which initially originated from a resected soft-tissue lesion in the left clavicular region in 2007. In addition, a locally recurrent lesion was resected and the patient received brachytherapy in 2015. Moreover, a metachronous metastatic lesion in the right lung was resected in 2017. Histopathological examination confirmed that all lesions were myoepithelioma. In the present case, pancreatoduodenectomy and right hemithyroidectomy for both metastatic lesions were successfully performed. Histopathology revealed small round-to-spindle-shaped tumor cells with atypia, proliferating in reticular formation, accompanied by myxoid stroma with chondromyxoid and hyalinized stroma, and the histology was similar to that observed in the previous specimen. Immunohistochemistry revealed positivity for cytokeratin (AE1/AE3), glial fibrillary acidic protein, vimentin, and S-100, and confirmed the diagnosis of myoepithelioma. To the best of our knowledge, this is the first study presenting a long-term survivor of soft-tissue myoepithelioma who underwent repeated multiple rounds of resection for recurrence in various organs. Conclusions: We reported the case of a long-term survivor of soft-tissue myoepithelioma requiring multiple rounds of surgical resection for local recurrence and metachronous metastases in the lung, pancreas, and thyroid. When managed appropriately, some patients might benefit in terms of survival from repeated resection of recurrent lesions.

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Section: Discussionmentioning

confidence: 99%

Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor

et al. 2020

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“…Carcinoma only comprises approximately 10% of all myoepithelial neoplasms [11,12]. Some characteristics of a carcinoma include aggressive behavior (infiltrative and destructive growth), increased mitotic activity, necrosis, lack of myofilaments (therefore more monomorphic than benign myoepithelioma), and cell pleomorphism [3] [5].…”

Section: Discussionmentioning

confidence: 99%

Myoepithelioma of parotid gland – a diagnosis of immunohistochemistry

Sahai

Sahu

M.B

et al. 2019

Trop J Pathol Microbiol

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Myoepitheliomas are rare benign tumours occurring from any secretory system of the body having myoepithelial cells. In the salivary glands they have an occurrence of 1% with the parotid gland being the most commonly affected gland. The epithelioid variant consists of nests or cords of round to polygonal cells, with centrally located nuclei and a variable amount of eosinophilic cytoplasm. Since this variant is rare and myoepitheliomas can mimic other benign as well as neoplastic conditions, immunohistochemistry is useful for coming to a conclusive diagnosis. We present a case of epithelioid myoepithelioma diagnosed at our institution with the help of immunohistochemistry.

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“…It is a rare benign mass arising from neoplastic myoepithelial or basket cells, which are found between the basement membrane and the basal plasma membrane of acinar cells. 4 Majority of these tumors arise in parotid gland followed by minor salivary glands of palate. The tumor does not show any unique clinicopathologic features that is different from other benign salivary gland tumors but is believed to have more aggressive behaviour.…”

Section: Discussionmentioning

confidence: 99%

Myoepithlioma of Soft Palate: a case report

Baral¹,

Ojha²,

Bajracharya³

et al. 2018

J Coll Med Sci-Nepal

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Myoepithelioms are rare benign salivary gland tumors representing 1-1.5% of all salivary gland tumors. It was once considered to be one end of the histologic spectrum of pleomorphic adenoma (PA), but myoepitheliomas today are believed to be distinct entity. Herein we report a case of myoepithelioma in a 49 years old female patient with the history of swelling in the soft and hard palate. The diagnosis was made on the basis of histopathological findings and immunohistochemical report.

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Myoepithelioma of the Parotid Gland: A Case Report with Review of the Literature and Classic Histopathology

Cited by 18 publications

References 16 publications

Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor

Metachronous Pancreatic and Thyroid Metastases from Primary Soft-Tissue Myoepithelioma in the Clavicular Region: A Case Report of a Long-Term Survivor

Myoepithelioma of parotid gland – a diagnosis of immunohistochemistry

Myoepithlioma of Soft Palate: a case report

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