Myofibroblastoma of the Breast: Literature Review and Case Report

Metry, Mario; Shaaban, Mohamad; Youssef, Magdy M.; Carr, Michael

doi:10.1155/2016/1714382

Cited by 16 publications

(24 citation statements)

References 24 publications

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“…An association with gynecomastia has been reported but was not present in this patient [8]. Myofibroblastomas have also been reported at surgical scar sites following breast cancer excision [9], which may be secondary to the migration and transformation of fibroblasts to the tissue injury location [10]. Imaging features of myofibroblastoma are nonspecific.…”

Section: Discussionmentioning

confidence: 87%

Myofibroblastoma of the male breast: a rare entity with radiologic-pathologic correlation

et al. 2017

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A 73-year old man with a history of multiple genitourinary malignancies was found to have a left retroareolar soft tissue mass on CT assessment of disease, and dedicated breast imaging was recommended. Diagnostic mammography and ultrasonography confirmed a solid mass, for which biopsy was recommended. Pathologic analysis demonstrated a spindle cell neoplasm with an immunoreactivity pattern consistent with myofibroblastoma. While this entity is benign, nonspecific imaging features necessitate tissue sampling for pathologic diagnosis, and, given pathologic rarity, open communication between the radiologist and pathologist is important to establish the correct diagnosis and to recommend appropriate management.

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Section: Discussionmentioning

confidence: 87%

Myofibroblastoma of the male breast: a rare entity with radiologic-pathologic correlation

et al. 2017

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“…On mammography, myofibroblastomas are usually dense masses 1 to 4 cm in size, well defined, and with a round to ovoid shape (Figure A). On ultrasonography, they may show as homogeneously hypoechoic masses like fibroadenomas, or heterogeneous echoic masses such as hamartomas . In our case, a well‐circumscribed, heterogeneously hypoechoic mass was observed (Figure , B–D).…”

Section: Benign Diseases Of the Male Breastmentioning

confidence: 52%

Ultrasonographic and Mammographic Findings of Male Breast Disease

Kim

2018

J of Ultrasound Medicine

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Most male breast diseases are benign, although malignancies can also occur. Gynecomastia, the most common abnormality in the male breast, has characteristic imaging findings differentiating it from cancer. Fewer than 1% of patients with breast cancer are men, but the incidence of male breast cancer is increasing worldwide. Additionally, breast cancer often presents at a more advanced stage in men than in women due to delayed diagnosis. Understanding imaging features of male breast disease is important for an accurate diagnosis and optimal care. This article reviews ultrasonography and mammography findings of benign and malignant diseases of the male breast.

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“…25 In histopathology, myofibroblastoma is presented as some bipolar spindle-shaped cells showing variable myogenic and fibroblastic differentiation in short intersecting fascicles interrupted by keloidal like eosinophilic collagen bands. 25,26 In immunohistochemistry, myofibroblastoma stains positively for Vimentin, Desmin, and CD34. Positively stained with estrogen, progesterone, androgen receptors, SMA, S100, bcl-2 and negatively for CD31, and cytokeratin are detected in some types of myofibroblastoma.…”

Section: Discussionmentioning

confidence: 99%