Myofibroblasts in basal cell epithelioma: with special reference to the phagocytic function of myofibroblasts

Nagao, S; Nemoto, Hiroyuki; Suzuki, Misako; Satoh, Norio; Iijima, Satoshi

doi:10.1111/j.1600-0560.1986.tb01521.x

Cited by 9 publications

(7 citation statements)

References 14 publications

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“…Many patterns of this tumor have been described including solid, cystic, pigmented, infiltrating, keratotic, adenoid and sclerosing with epidermal attachment identified in most cases 18–21 . Additionally, the nests of basal cell carcinoma show prominent palisading and cleft‐like retraction spaces seen between the epithelial nests and the loose basophilic stroma 22,23 . Basal cell carcinoma sometimes show sebaceous differentiation, which can be confused with sebaceous carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Immunohistochemistry in ocular carcinomas

Sramek¹,

Lisle

Loy

2008

J Cutan Pathol

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Section: Discussionmentioning

confidence: 99%

Immunohistochemistry in ocular carcinomas

Sramek¹,

Lisle

Loy

2008

J Cutan Pathol

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“…The density of pericytes and the number and size of cytoplasmic processes suggested to us that the corpus luteum was particularly dependent upon pericyte vascular support. Finally, at the center of some corpora lutea, the foci of aSMA-positive cells were present around areas of cell debris suggesting perhaps a transitory phagocytic role for aSMA þ myofibroblasts (Nagao et al 1986). …”

Section: Discussionmentioning

confidence: 99%

PDGFR Inhibition Results in Pericyte Depletion and Hemorrhage into the Corpus Luteum of the Rat Ovary

et al. 2015

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The growth plate, ovary, adrenal gland, and rodent incisor tooth are sentinel organs for antiangiogenic effects since they respond reliably, quantitatively, and sensitively to inhibition of the vascular endothelial growth factor receptor (VEGFR). Here we report that treatment of rats with platelet-derived growth factor receptor beta (PDGFRb) inhibitors that target pericytes results in severe ovarian hemorrhage with degeneration and eventual rupture of the corpus luteum. Evaluation of the growth plate, adrenal gland, and incisor tooth that are typical target organs for antiangiogenic treatment in the rodent revealed no abnormalities. Histologically, the changes in the ovary were characterized by sinusoidal dilatation, increased vessel fragility, and hemorrhage into the corpus luteum. Immunocytochemical staining of vessels with alpha smooth muscle actin and CD31 that recognize pericytes and vascular endothelium, respectively, demonstrated that this effect was due to selective pericyte deficiency within corpora lutea. Further experiments in which rats were treated concurrently with both PDGFRb and VEGFR inhibitors ablated the hemorrhagic response, resulting instead in corpus luteum necrosis. These changes are consistent with the notion that selective pericyte loss in the primitive capillary network resulted in increased vessel fragility and hemorrhage, whereas concomitant VEGFR inhibition resulted in vessel regression and reduced vascular perfusion that restricted development of the hemorrhagic vessels. These results also highlight the utility of the rodent ovary to respond differentially to VEGFR and PDGFR inhibitors, which may provide useful information during routine safety assessment for determining target organ toxicity.

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“…Assays for hGH production were performed as follows. Murine B6 fibroblasts were transfeced in triplicate with 30 pg ofplasmid DNA by calcium phosphate precipitation (8) 20 October 1987 observed and viable bacteria have been isolated from the epithelial cells (12)(13)(14)(15)(16)(17)(18)(19)(20). These findings suggest that some forms of adenocarcinoma of the ascending colon may have an infectious component to their etiologies (12,13).…”

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confidence: 98%

“…14,2863(1986). 16 Routine histological and cytological examination of tissues and cells taken from human tumors also frequently shows the presence of intracytoplasmic particles (5)(6)(7)(8)(9)(10)(11), sug-gesting that this phenomenon is not just an in vitro artifact. The presence of intraco plasmic bacteria in hyperplastic and dysplastic gut epithelium ofseveral species has been II DECEMBER I987 J. Biol.…”

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confidence: 99%

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Phagocytosis of Candida albicans Enhances Malignant Behavior of Murine Tumor Cells

Ginsburg

Fligiel

Kunkel

et al. 1987

Science

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Murine tumor cells were induced to phagocytize either Candida albicans or group A streptococcal cells. The presence of microbial particles within the tumor cell cytoplasm had no effect on in vitro tumor cell growth. However, when Candida albicans-infected tumor cells were injected into syngeneic mice, they formed tumors that grew faster, invaded the surrounding normal tissue more rapidly and metastasized more rapidly than control tumor cells. Tumor cells infected with group A streptococcal particles did not grow faster or show increased malignant behavior. These data indicate that the in vivo behavior of malignant tumor cells can be modulated by microbial particles, which are often present in the microenvironment of the growing tumor.

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Myofibroblasts in basal cell epithelioma: with special reference to the phagocytic function of myofibroblasts

Abstract: Three cases of basal cell epithelioma were studied with light and electron microscopy. Myofibroblasts, some containing melanosomes, were observed in the stroma of the tumors. The significance of these cells in the tumor is briefly discussed.

Cited by 9 publications

References 14 publications

Immunohistochemistry in ocular carcinomas

Immunohistochemistry in ocular carcinomas

PDGFR Inhibition Results in Pericyte Depletion and Hemorrhage into the Corpus Luteum of the Rat Ovary

Phagocytosis of Candida albicans Enhances Malignant Behavior of Murine Tumor Cells

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