Myofibromatosis-like Hemangiopericytoma Metastasizing as Differentiated Vascular Smooth-Muscle and Myosarcoma

Dictor, Michael; Elner, Å; Andersson, Tobias; Fernö, Mårten

doi:10.1097/00000478-199212000-00011

Cited by 76 publications

(79 citation statements)

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“…7 This concept accounts for the spectrum of tumours and may explain the distinctive features of each variety. [4][5][6][7][8] The relation to the so called perivascular epithelioid cell is not known. However, Abbreviations: GPC, glomangiopericytoma; HPC, haemangiopericytoma; MF, myofibroma; MPC, myopericytoma; SMA, smooth muscle actin; WHO, World Health Organisation because perivascular epithelioid cell tumours show different morphological and immunohistochemical characteristics (epithelioid cells, HMB45 positive staining, and a propensity to involve intra-abdominal rather than peripheral sites), they appear to be unrelated to MPC.…”

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confidence: 99%

Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases

Dray

McCarthy²,

Palmer³

et al. 2006

J Clin Pathol

151

198

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Background: Myopericytoma (MPC) is a recently proposed term to describe a group of tumours that originate from perivascular myoid cells and show a range of histological growth patterns. Only a small number of series describing MPC have been reported. MPC is frequently misdiagnosed as a sarcoma. Aims: To document the clinical and histopathological findings of a series of MPCs, to describe the range of growth patterns and morphological spectrum, and to compare MPC with myofibroma (MF). Patients/Methods: Fourteen patients with features of MPC and/or MF were identified from the archival files of the department of anatomical pathology, Royal Prince Alfred Hospital, Sydney, Australia. Results: There were six female and eight male patients. The mean and median patient ages were 37 and 35.5 years, respectively. The tumours were located in the skin, subcutis, or superficial soft tissues of the distal extremities (13 patients) or the head and neck region (one patient), and showed a spectrum of morphological appearances. They were divided into two groups based upon the predominant growth pattern corresponding to MPC (seven cases) and MF (seven cases). The feature most suggestive of MPC was the presence of a concentric perivascular arrangement of plump spindle shaped cells. The presence of a zonation/biphasic appearance was most characteristic of MF. Conclusions: MPC exhibits a spectrum of growth patterns that overlap with MF. Tumours can be designated as MPC or MF depending on the predominant growth pattern.

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confidence: 99%

Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases

Dray

McCarthy²,

Palmer³

et al. 2006

J Clin Pathol

151

198

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“…Ultra structurally, origin of this tumor is from pericytes which are perivascular stem cells and considered to be pleuripotent and capable of differentiating into smooth muscle cells and glomus cells. [7] The term myopericyte coined by Dictor et al [9] was used to denote atypical pericytes surrounded by bundles of sclerotic smooth muscle abutting on staghorn vessels. Myo pericytes represent a transitional form between pericytes and smooth muscle cell of vessels [10] .…”

Section: Discussionmentioning

confidence: 99%

Myopericytoma -A Perivascular Myoid Cell Tumor with Review of Literature

Mangal¹

2017

JMSCR

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“…A review of the literature (Table I) regarding HPC of the thyroid gland showed that it is extremely rare (9-10), with only 9 cases being reported thus far (11)(12)(13)(14)(15)(16)(17)(18)(19).…”

Section: Discussionmentioning

confidence: 99%

A case of metastatic haemangiopericytoma to the thyroid gland: Case report and literature review

et al. 2012

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Abstract. Haemangiopericytoma (HPC) is a mesenchymal neoplasm accounting for a minority of all vascular tumours. HPC mostly arises in the lower extremities and the retroperitoneum, while the head and neck area is the third most common site. The majority of HPCs are histologically benign. However, a small percentage possess atypical features, such as a high mitotic rate, high cellularity and foci of necrosis. We report a case of classical abdominal HPC that presented 7 years after the first surgical resection with thyroid metastases of malignant HPC. Microscopic examination revealed multiple hypercellular nodules with an infiltrative growth pattern. These nodules consisted of tightly packed fusiform or spindle-shaped cells with nuclear polymorphism and an increased mitotic rate. The tumour cells exhibited a marked expression of CD34. Cells were arranged around a prominent vascular network, occasionally with a 'staghorn' configuration. The results of this study support and confirm the theory that HPC is a rare neoplasm with unpredictable behaviour, as largely debated in the international literature. Therefore, this study emphasized the importance of applying strict diagnostic criteria in making the most appropriate diagnosis.

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Myofibromatosis-like Hemangiopericytoma Metastasizing as Differentiated Vascular Smooth-Muscle and Myosarcoma

Cited by 76 publications

References 0 publications

Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases

Myopericytoma: a unifying term for a spectrum of tumours that show overlapping features with myofibroma. A review of 14 cases

Myopericytoma -A Perivascular Myoid Cell Tumor with Review of Literature

A case of metastatic haemangiopericytoma to the thyroid gland: Case report and literature review

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