Eighty basal cell carcinomas (BCCs) in 21 patients, 10 lesions of Bowen's disease in three patients, and four lesions of cutaneous T-cell lymphoma in two patients, were treated with photodynamic laser therapy (PDT), using topical application of the haem precursor delta-amino levulinic acid (ALA). The diagnoses were confirmed histologically prior to treatment. Fifty-five of the BCCs were superficial lesions, and 25 were nodular. Of the 80 BCCs, 39 (49%) were located on the trunk, 36 (45%) on the head and neck region, four (15%) on the leg and one on the arm. The two principal locations of the 10 Bowen's disease lesions were the leg (50%) and the trunk (40%). The T-cell lymphoma lesions were located on the shoulder and on the arm. A water-in-oil based cream containing 20% ALA was applied to the lesions, with a margin of about 10-20 mm beyond the visible tumour border, 4-6 h before the laser procedure. During this period of time the highly fluorescent and photodynamically active substance protoporphyrin IX (Pp IX) is synthesized via the haem cycle. Laser-induced fluorescence (LIF) was used for real-time monitoring of the Pp IX distribution in the tumour and in the normal surrounding skin, before and after treatment in all patients. Before laser treatment the Pp IX distribution demonstrated by LIF showed a demarcation between tumour and normal skin of about 15:1 for BCC and Bowen's disease, and 5:1 for T-cell lymphomas.(ABSTRACT TRUNCATED AT 250 WORDS)

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In this paper, the development of decision support tools for dynamic ambulance relocation and automatic ambulance dispatching is described.

In this paper, the development of decision support tools for dynamic ambulance relocation and automatic ambulance dispatching is described.

Purpose: To quantitatively and qualitatively evaluate the water-signal performance of the Consistent Intensity Inhomogeneity Correction (CIIC) method to correct for intensity inhomogeneities.Materials and Methods: Water-Fat volumes were acquired using 1.5 T and 3.0 T symmetrically sampled 2-point Dixon 3D MRI. Two datasets: 1) 10 muscle tissue ROIs from 10 subjects acquired with both 1.5 T and 3.0 T whole-body MRI. 2) 7 liver tissue ROIs from 36 patients imaged using 1.5 T MRI at six time points after Gd-EOB-DTPA injection. The performance of CIIC was evaluated quantitatively by analyzing its impact on the dispersion and bias of the water image ROI intensities, and qualitatively using side-by-side image comparisons.