Myogenous temporomandibular disorders and salivary markers of oxidative stress—A cross‐sectional study

Madariaga, Víctor Ignacio; Jasim, Hajer; Ghafouri, Bijar; Ernberg, Malin

doi:10.1111/joor.13100

Cited by 12 publications

(10 citation statements)

References 49 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Secondly, for the genetic factors that can contribute to pain perception, proinflammatory cytokines and extracellular matrix breakdown may affect the female predilection [55]. Thirdly, the psychosocial factors that contain an enhanced response to stress stimuli, distress, anxiety, depression, or reduced coping strategies have been reported to make gender differences [56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

Gender Differences in Clinical Characteristics of Korean Temporomandibular Disorder Patients

Chung

2021

Applied Sciences

View full text Add to dashboard Cite

The aims of this study were to investigate the gender differences in signs and symptoms of Korean Temporomandibular Disorder (TMD) patients based on Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD) and psychosocial characteristics. A total of 1052 patients with TMD were evaluated with a questionnaire for medical history, clinical symptoms, and contributing factors, clinical examination based on RDC/TMD, and radiographic examination. RDC/TMD axis II and Symptom Checklist-90-Revision (SCL-90-R) were administered to evaluate pain-related disability level and psychological status of patients. The prevalence of TMD was higher in women than men, and the women were older than the men. The women showed higher prevalence of myogenous pain, mixed pain, disc displacement without reduction, osteoarthritis, headache, subjective insomnia, pain intensity, number of positive muscle palpation, and the high disability group in the grade chronic pain scale. Gender was associated with the number of positive muscle palpation and maximum mouth opening. Pain intensity was not associated with gender, but with number of systemic comorbidities. Subjective symptoms, and clinical and psychological characteristics of patients with TMD showed gender differences. To achieve understanding of patient and increase of success rate of treatment of TMD, gender should be considered in patient evaluations and treatment approaches.

show abstract

Section: Discussionmentioning

confidence: 99%

Gender Differences in Clinical Characteristics of Korean Temporomandibular Disorder Patients

Chung

2021

Applied Sciences

View full text Add to dashboard Cite

show abstract

“…The level of 5HT in the masseter muscle evoked by hypertonic saline injection is increased in healthy controls [ 32 ], while myogenic TMD pain patients show higher 5HT levels in the masseter muscle by the acute injury compared to healthy controls [ 33 ]. Further, increases in antioxidative stress markers in the saliva, resulting from inflammatory processing, are identified in myogenous TMD patients; however, no correlation is seen between pain and the level of oxidative markers [ 34 ].…”

Section: Neural Mechanisms For Pain In the Deep Craniofacial Tissues In Humanmentioning

confidence: 99%

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Okamoto

Hasegawa

Piriyaprasath

et al. 2021

Japanese Dental Science Review

View full text Add to dashboard Cite

“…The hydroxyl radical scavenging capacity assay of polysaccharides and flavonoid was carried out by using the hydroxyl free radical scavenging capacity assay kit according to the principle that H 2 O 2 /Fe 2+ can generate hydroxyl free radical through Fenton reaction ( Lyngsie et al, 2018 ), and the experiment was carried out according to the instructions described in the kit manual (kit BC1325-100T/96S). The total antioxidant capacity of polysaccharides and flavonoid was determined using the total antioxidant capacity assay kit (kit BC1310-50T/48S) based on the reduction of Cu 2+ to Cu + ( Madariaga et al, 2021 ), and the experiment was carried out according to the instructions described in the kit manual.…”

Section: Methodsmentioning

confidence: 99%

Immune-enhancing activity of polysaccharides and flavonoids derived from Phellinus igniarius YASH1

Zhu

Guo

et al. 2023

Front. Pharmacol.

View full text Add to dashboard Cite

Introduction:Phellinus igniarius (P. igniarius) (Sanghuang) is a widely used traditional Chinese medicine fungus, and its natural products have great potential for clinical application in immune enhancement. This study aimed to explore the immune-enhancing activity and underlying mechanisms of the polysaccharides and flavonoids derived from Phellinus igniarius (P. igniarius) and to provide a theoretical and experimental basis for the development of novel drugs.Methods: Wild P. igniarius YASH1 from the Loess Plateau in Yan’an region was collected, and polysaccharides and total flavonoids were extracted, isolated and identified from mycelium and sporophore. In vitro antioxidant activity was detected through the scavenging activity of hydroxyl radicals and total antioxidant capacity. Cell Counting Kit-8 and trypan blue detection kit were used to detect the effect of extract polysaccharides and flavonoids on the proliferation and phagocytosis ability of immune cells. To assess the effect of the drugs on cytokine secretion by immune cells and immune recovery in immunocompromised mice, the expression of interleukin (IL)-2, IL-6, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α were examined at the cellular and animal levels. The species composition, abundance of gut microbiota and the altered content of short-chain fatty acids in the feces were analyzed to elucidate the possible mechanisms of drugs by 16S ribosomal RNA (rRNA) amplifiers sequencing and liquid chromatography-tandem mass spectrometry (LC-MS/MS).Results: Both polysaccharides and flavonoids derived from mycelium or sporophore had antioxidant activity and may stimulate the expression and secretion of IL-2, IL-6, and IFN-γ in immune cells while inhibiting TNF-α expression and secretion and increasing IL-2, IL-6, and IFN- γ expression levels in mice. Furthermore, polysaccharides and flavonoids from mycelium and sporophore showed different effects on the metabolic response of intestinal short-chain fatty acids (SCFAs) in mice, and the use of these drugs remarkably changed the species composition and abundance of intestinal flora in mice.Discussion: Polysaccharides and flavonoids from P. igniarius YASH1 mycelium and sporophore have in vitro antioxidant activity, and they affect the promotion of cell proliferation, stimulation of IL-2, IL-6, and IFN-γ secretion, and inhibition of TNF-α expression in immune cells. Polysaccharides and flavonoids from P. igniarius YASH1 may enhance immunity in immunocompromised mice and remarkably affect the intestinal flora and content of SCFAs.

show abstract

Myogenous temporomandibular disorders and salivary markers of oxidative stress—A cross‐sectional study

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 12 publications

References 49 publications

Gender Differences in Clinical Characteristics of Korean Temporomandibular Disorder Patients

Gender Differences in Clinical Characteristics of Korean Temporomandibular Disorder Patients

Preclinical models of deep craniofacial nociception and temporomandibular disorder pain

Immune-enhancing activity of polysaccharides and flavonoids derived from Phellinus igniarius YASH1

Contact Info

Product

Resources

About