Myoinositol: A new marker of intrauterine growth restriction?

Dessì, Angelica; Fanos, Vassilios

doi:10.3109/01443615.2013.831046

Cited by 32 publications

(24 citation statements)

References 43 publications

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“…Among the metabolites identified in the "galactose metabolism" pathway, the myo-inositol concentration had already been proposed as a marker of development of obesity and type 2 diabetes in human adults [14,26] and also as a marker of IUGR in humans [1,15] and pigs [40]. In these previous studies, a higher plasma or urine concentration of myo-inositol was associated with a higher risk of IUGR and, thus, with a lower maturity.…”

Section: Discussionmentioning

confidence: 99%

“…More precisely, in pigs, NMR metabolomic profiling performed on fetuses at 110 days of gestation has demonstrated that low-weight fetuses had a higher plasma concentrations of myo-inositol than high-weight fetuses [40]. Also, Dessì and Fanos [15] have suggested that, in fetus with IUGR, greater plasma concentrations of myo-inositol may reflect an altered glucose metabolism and that they were associated with a decrease in lipid synthesis and cell proliferation through the reduction in insulin secretion. Such effects then result in a lower birth weight.…”

Section: Discussionmentioning

confidence: 99%

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The maturity in fetal pigs using a multi-fluid metabolomic approach

Lefort

Servien

Quesnel

et al. 2020

Preprint

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In mammalian species, the first days after birth are an important period for survival and the rates of mortality before weaning are high. In pigs, the perinatal deaths average 20% of the litter, with important economic and societal consequences. Among the factors influencing piglet survival at birth, the maturity is likely to be one of the most important. Maturity can be defined as the outcome of complex mechanisms of intra-uterine development and maturation occurring during the last month of gestation. Here, we provide new insights on maturity by studying the end of gestation at two different stages (three weeks before term and close to term) in two breeds of pigs that strongly differ in terms of neonatal survival. Since metabolomics is a promising approach for phenotype characterization or biomarker discovery, we provide a complete understanding of the metabolome of the fetuses in late gestation in three fluids (plasma, urine, and amniotic fluid). We found that biological processes related to amino acid and carbohydrate metabolisms are critical for piglet maturity. We also confirmed some previously described metabolites associated with delayed growth (e.g., proline and myo-inositol). Altogether, our study proposes new routes for a better characterization of piglet maturity at birth.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The maturity in fetal pigs using a multi-fluid metabolomic approach

Lefort

Servien

Quesnel

et al. 2020

Preprint

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“…It can be hypothesized that reduced production of fetal insulin leads to an excretion of inositol from the intracellular compartment to the extracellular compartment with a subsequent increase of this metabolite in plasma and urine and a reduction inside the cells. In fact, in our studies that analyzed urine of IUGR and large for gestational age infants, its content was significantly increased compared to controls [1,47]. Plasma and urinary increase of this metabolite, often correlated to glucose intolerance and insulin resistance in adults, could also be considered as a valid marker of altered carbohydrate metabolism during fetal development in IUGR [48].…”

Section: Inositolmentioning

confidence: 97%

Clinical Metabolomics in Neonatology: From Metabolites to Diseases

Fanos¹,

Pintus²,

Dessì³

2018

Neonatology

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Today, disorders that affect the newborn remain a challenge for physicians because of the enigmatic pathophysiology and difficulties in treating such delicate patients. Metabolomics, the “omics” science that studies the metabolome, namely the metabolites present in biological fluids, such as saliva, blood, sweat, and breast milk in a given time or condition, can be useful in helping neonatologists to prevent, diagnose, and treat diseases affecting the neonate, especially those with higher mortality rates. Since it is a relatively new technology, studies of its application in neonatology are limited. The aims of this review are to present metabolomics data on relevant neonatal disorders and to identify and discuss the most important 5 metabolites and their clinical significance rather than focusing on each disorder. The preliminary data are promising but further studies on metabolomics in neonatology are needed together with the standardization of results before their application in clinical practice.

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“…An altered glucid metabolism during fetal development in neonates with intrauterine growth retardation (IUGR) has recently been suggested to be reflected by the increase in extracellular myoinositol that may be considered a valid predictive marker of the development of obesity and type 2 diabetes (T2D) in adulthood [16, 17]. Inositol is in fact known as a secondary messenger of the insulin transducer signal; it is also known that insulin plays a role in favoring lipid and provide synthesis as well as cell growth [18]. In the case of fetal malnutrition (both too much and not enough), it is thus possible to hypothesize that at birth there is a situation of reduced sensitivity to insulin which may be revealed by an increase in extracellular inositol.…”

Section: Metabolomics and Nutrition In Neonatologymentioning

confidence: 99%

Clinical Metabolomics and Nutrition: The New Frontier in Neonatology and Pediatrics

Dessì

Marincola

Masili

et al. 2014

BioMed Research International

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In the pediatric clinic, nutritional research is focusing more and more on preventing the development of long-term diseases as well as supporting the repair processes important in the therapy of already fully developed diseases. Most children who are hospitalized or affected by chronic diseases could benefit from specific and careful attention to nutrition. Indeed, the state of nutrition modulates all body functions, including the different metabolic processes which, all together, have a profound effect on the development of the health and future of all individuals. Inappropriate food, even in the first periods of life, can accelerate the development of chronic metabolic diseases, especially in the pediatric age. To gain further insights into metabolic cycles and how they are connected with diet and health, nutrition and metabolomics interact to develop and apply modern technologies for metabolic assessment. In particular, nutritionists are evaluating the metabolomic approach to establish the single nutritional phenotypes, that is, the way in which diet interacts with individuals' metabolisms. This strategy offers the possibility of providing a complete definition of the individual's nutritional and health status, predict the risk of disease, and create metabolomic databases supporting the development of “personalized nutrition,” in which diet is attuned to the nutritional needs of individual patients.

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Myoinositol: A new marker of intrauterine growth restriction?

Cited by 32 publications

References 43 publications

The maturity in fetal pigs using a multi-fluid metabolomic approach

The maturity in fetal pigs using a multi-fluid metabolomic approach

Clinical Metabolomics in Neonatology: From Metabolites to Diseases

Clinical Metabolomics and Nutrition: The New Frontier in Neonatology and Pediatrics

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