Myopathology of non-infectious inflammatory myopathies – The current status

Hewer, Ekkehard; Goebel, Hans H.

doi:10.1016/j.prp.2008.03.006

Cited by 25 publications

(14 citation statements)

References 48 publications

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“…Histopathological analysis of patients with a range of myopathies has demonstrated inflammatory infiltrates in the muscle tissues, primarily macrophages (Hewer & Goebel, 2008) and mononuclear cells. Infiltration of these cells is characteristic of idiopathic inflammatory myopathies.…”

Section: Cellular Factors In Alphavirus Induced Myopathiesmentioning

confidence: 99%

Arthrogenic Alphaviruses and Inflammatory Myopathies

Herrero¹,

Mahalingam²

2011

Idiopathic Inflammatory Myopathies - Recent Developments

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Section: Cellular Factors In Alphavirus Induced Myopathiesmentioning

confidence: 99%

Arthrogenic Alphaviruses and Inflammatory Myopathies

Herrero¹,

Mahalingam²

2011

Idiopathic Inflammatory Myopathies - Recent Developments

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“…Inflammatory myopathies secondary to infectious causes, however, often have eosinophilic infiltrates in addition to lymphocytes . Eosinophils also have been found in inflammatory myopathies such as CMMM in dogs and eosinophilic polymyositis in humans . Muscle inflammation also may be a predominant pathological finding in dysferlin‐deficient muscular dystrophy in humans …”

mentioning

confidence: 99%

Major Histocompatibility Complex I and II Expression and Lymphocytic Subtypes in Muscle of Horses with Immune‐Mediated Myositis

Durward‐Akhurst

Finno

Barnes

et al. 2016

Veterinary Internal Medicne

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BackgroundMajor histocompatibility complex (MHC) I and II expression is not normally detected on sarcolemma, but is detected with lymphocytic infiltrates in immune‐mediated myositis (IMM) of humans and dogs and in dysferlin‐deficient muscular dystrophy.Hypothesis/ObjectivesTo determine if sarcolemmal MHC is expressed in active IMM in horses, if MHC expression is associated with lymphocytic subtype, and if dysferlin is expressed in IMM.AnimalsTwenty‐one IMM horses of Quarter Horse‐related breeds, 3 healthy and 6 disease controls (3 pasture myopathy, 3 amylase‐resistant polysaccharide storage myopathy [PSSM]).MethodsImmunohistochemical staining for MHC I, II, and CD4+, CD8+, CD20+ lymphocytes was performed on archived muscle of IMM and control horses. Scores were given for MHC I, II, and lymphocytic subtypes. Immunofluorescent staining for dysferlin, dystrophin, and a‐sarcoglycan was performed.ResultsSarcolemmal MHC I and II expression was detected in 17/21 and 15/21 of IMM horses, respectively, and in specific fibers of PSSM horses, but not healthy or pasture myopathy controls. The CD4+, CD8+, and CD20+ cells were present in 20/21 IMM muscles with CD4+ predominance in 10/21 and CD8+ predominance in 6/21 of IMM horses. Dysferlin, dystrophin, and a‐sarcoglycan staining were similar in IMM and control muscles.Conclusions and clinical importanceDeficiencies of dysferlin, dystrophin, and a‐sarcoglycan are not associated with IMM. Sarcolemmal MHC I and II expression in a proportion of myofibers of IMM horses in conjunction with lymphocytic infiltration supports an immune‐mediated etiology for IMM. The MHC expression also occured in specific myofibers in PSSM horses in the absence of lymphocytic infiltrates.

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“…Muscle biopsy (open needle) is increasingly the test of choice in diagnosis and subclassification 4,5 in combination with the clinical features. The characteristic changes on muscle biopsy of DM, PM, and IBM have distinct immunopathogenic mechanisms.…”

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confidence: 99%