Myostatin increases the expression of matrix metalloproteinase genes to promote preadipocytes differentiation in pigs

Zhu, Zhe; Ali, Akhtar; Wang, Jing; Qi, Shijin; Hua, Zhen; Ren, Hongyan; Zhang, Liping; Gu, Hao; Molenaar, Adrian; Babar, Masroor Ellahi; Bi, Ye

doi:10.1080/21623945.2022.2065715

Cited by 2 publications

(3 citation statements)

References 32 publications

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“…RNAi was applied to investigate the porcine MSTN gene. − However, to the best of our knowledge, no MSTN knockdown pigs were generated using this approach. ZNFs were applied to target the porcine MSTN in somatic cells , and to generate live ZFNs-mediated MSTN -edited pigs − (Table ).…”

Section: Targeting the Mstn Gene In Pigsmentioning

confidence: 99%

“…It was also shown that MSTN has a functional partition to coordinate both adipogenesis and myogenesis, and MSTN acts through the MEF2C /miR222/ SCD5 cascade to regulate fatty acid metabolism . Furthermore, MSTN was shown to increase the expression of matrix metalloproteinase genes to promote preadipocyte differentiation …”

Section: Targeting the Mstn Gene In Pigsmentioning

confidence: 99%

“…95 Furthermore, MSTN was shown to increase the expression of matrix metalloproteinase genes to promote preadipocyte differentiation. 50…”

Section: ■ Targeting the Mstn Gene In Pigsmentioning

confidence: 99%

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When Less Is More: Targeting the Myostatin Gene in Livestock for Augmenting Meat Production

Kalds

Zhou

Huang

et al. 2023

J. Agric. Food Chem.

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How to increase meat production is one of the main questions in animal breeding. Selection for improved body weight has been made and, due to recent genomic advances, naturally occurring variants that are responsible for controlling economically relevant phenotypes have been revealed. The myostatin (MSTN) gene, a superstar gene in animal breeding, was discovered as a negative controller of muscle mass. In some livestock species, natural mutations in the MSTN gene could generate the agriculturally desirable double-muscling phenotype. However, some other livestock species or breeds lack these desirable variants. Genetic modification, particularly gene editing, offers an unprecedented opportunity to induce or mimic naturally occurring mutations in livestock genomes. To date, various MSTN-edited livestock species have been generated using different gene modification tools. These MSTN gene-edited models have higher growth rates and increased muscle mass, suggesting the high potential of utilizing MSTN gene editing in animal breeding. Additionally, post-editing investigations in most livestock species support the favorable influence of targeting the MSTN gene on meat quantity and quality. In this Review, we provide a collective discussion on targeting the MSTN gene in livestock to further encourage its utilization opportunities. It is expected that, shortly, MSTN gene-edited livestock will be commercialized, and MSTN-edited meat will be on the tables of ordinary customers.

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Section: Targeting the Mstn Gene In Pigsmentioning

confidence: 99%

Section: Targeting the Mstn Gene In Pigsmentioning

confidence: 99%

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When Less Is More: Targeting the Myostatin Gene in Livestock for Augmenting Meat Production

Kalds

Zhou

Huang

et al. 2023

J. Agric. Food Chem.

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Emerging Materials in Cultivated Meat: Engineering Sustainable Food Solutions – A Review

Wang,

Li,

et al. 2024

Adv Funct Materials

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As the global population grows, the demand for protein‐enriched foods like meats is rising rapidly. Traditional farming practices face challenges including animal welfare, waste management, and carbon emissions, harming the environment. Consequently, meat substitutes have emerged as a promising area of research and as an alternative to traditional livestock‐sourced meats. Cultivated meat, produced through cell culture techniques, is a key area in cellular agriculture and offers a safe and well‐controlled production process for such future foods. The manufacturing of cultivated meat involves several disciplines, including cell culture, media optimization, scaffold design, and advanced manufacturing, along with nutrition, taste and safety topics to meet consumer acceptance and regulatory approvals. Although several review articles have addressed various aspects of cultivated meat, they tend to focus on specific domains rather than a comprehensive analysis of this transformative technology. This review highlights innovative and applied research findings in the field of cultivated meat, with a focus on critical aspects such as nutrition, cells, materials, and scaffold manufacturing technologies. Furthermore, the socio‐political and economic impacts of cultivated meat are explored, and practical recommendations for low‐cost and large‐scale production. Finally, the review also addresses existing challenges and outlines future directions for the development of cultivated meat.

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Myostatin increases the expression of matrix metalloproteinase genes to promote preadipocytes differentiation in pigs

Cited by 2 publications

References 32 publications

When Less Is More: Targeting the Myostatin Gene in Livestock for Augmenting Meat Production

When Less Is More: Targeting the Myostatin Gene in Livestock for Augmenting Meat Production

Emerging Materials in Cultivated Meat: Engineering Sustainable Food Solutions – A Review

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