Myostatin maps to the interval containing the bovine mh locus

Smith, Timothy P. L.; Lopez-Corrales, Nestor L.; Kappes, S. M.; Sonstegard, Tad S.

doi:10.1007/s003359900557

Cited by 86 publications

(47 citation statements)

References 11 publications

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“…In cattle, the myostatin gene is located at 3.1 cM (centimorgan) from the centromeric region on chromosome 2 (BTA2), next to microsatellite TGLA44 (Charlier et al, 1995;Grobet et al, 1997;Smith et al, 1997). Molecular analysis has shown that this gene consists of three exons and two introns, with 373, 374 and 381 nucleotides in each exon, and 1840 and 2033 nucleotides in each intron (Jeanplong et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle

Grisolia¹,

D’Angelo²,

Porto-Neto³

et al. 2009

Genet. Mol. Res.

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ABSTRACT. The myostatin gene, also known as GDF8 (growth differentiation factor 8), is located on bovine chromosome 2 (BTA2); it has three exons and two introns. Myostatin is specifically expressed during embryonic development and in adult skeletal muscle, functioning as a negative regulatory protein. Several cattle breeds (Piedmontese, Belgian Blue and Blond'Aquitaine, and others) show polymorphisms in this gene; these polymorphisms are directly related to the double muscling phenotype. We looked for polymorphisms in the Nellore cattle myostatin gene and compared them with those known for taurine breeds. Seven regions, covering the three exons of this gene, were amplified by polymerase chain reaction and sequenced, including the untranslated region. DNA from 30 adult Nellore animals was collected; DNA sequencing revealed three, seven and four polymorphisms in exons 1, 2 and 3, respectively. We found previously reported polymorphisms, as well as several new ones; for instance, 37 polymorphisms were found in the untranslated region segment, and in introns 1 and 2 there were one and three polymorphisms, respectively. The high degree of allelic heterogeneity in the myostatin gene could be related to its high mutation rate; it also could be the result of a long history of artificial selection for meat production, which has probably favored such modifications and maintained them in cattle populations. These polymorphisms identified in Nellore cattle could be useful for breeding programs.

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Section: Introductionmentioning

confidence: 99%

Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle

Grisolia¹,

D’Angelo²,

Porto-Neto³

et al. 2009

Genet. Mol. Res.

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“…These crossbred progeny produced from 1988 to 1997 also were included in the analysis. In Cycle V, F 1 cross progeny of Hereford, Angus, and MARC III dams sired by two British breeds (Hereford and Angus), two Continental European breeds (Piedmontese and Belgian Blue, all sires were homozygous for an inactive myostatin allele that causes muscle hypertrophy, Smith et al, 1997), and two tropically adapted Bos indicus breeds (Brahman and Boran) produced in 1992 to 1994 were included in the analysis. Also included were the progeny produced from 1994 to 2002 by the Cycle V F 1 cross females to evaluate maternal performance when they were raising calves by Red Poll sires at 2 yr of age, and by Charolais or F 1 Belgian Blue sires (Belgian Blue × Angus, Belgian Blue × Hereford, and Belgian Blue × MARC III) sires at 3 to 8 yr of age.…”

Section: Datamentioning

confidence: 99%

Influence of breed, heterozygosity, and disease incidence on estimates of variance components of respiratory disease in preweaned beef calves

Snowder

Vleck

Cundiff

et al. 2005

Journal of Animal Science

100

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ABSTRACT:The objective of this study was to characterize genetic and environmental factors influencing bovine respiratory disease (BRD) in beef cattle. Records from nine purebred and three composite breeds and a variety of F 1 and three-way crosses, including the progeny of 12 additional different sire breeds produced over a 20-yr period (1983 to 2002), were evaluated for breed and heterozygosity effects on the observed incidence of BRD. Heterozygosity fractions for calves and dams were defined by generalized breed origins: British, Continental, and tropically adapted. Variance components were estimated for each pure and composite breed, and across all breeds and crossbreeds. The effect of incidence of observed BRD was determined by comparing groups of low and high years of incidence. Respiratory disease in this herd followed a standard epidemiological pattern of initial introduction, reaching an epidemic stage at 70 to 170 d of age, followed by a period of rapid decrease to weaning. Estimates of heritability of incidence of BRD were low, ranging from 0.00 to 0.26, with overall estimates of 0.07 and 0.19 depending on

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“…Connor et al (4), using a compensatory gain model, identified specific hepatic mitochondrial gene expression patterns implicating them as putative hepatic arbiters and/or biomarkers for increased nutrient use efficiency in compensating steers. Selection for quantitative trait loci in beef cattle that exert influence on carcass characteristics has resulted in the industry making progress in the development of improved carcass marbling and tenderness (3) and muscle growth (21). Recently, identification and classification of genes associated with muscle growth (7,11,18,22,23) and adipogenesis (28) have been obtained from use of microarray transcript data.…”

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confidence: 99%

Characterization of the longissimus lumborum transcriptome response to adding propionate to the diet of growing Angus beef steers

Baldwin

et al. 2012

Physiological Genomics

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Development of management paradigms that enhance the rate of gain and qualitative characteristics of beef carcass development has the potential to impact production and nutrient use efficiency but also mitigate losses to the environment. We used eight Black Angus beef steers (272.5 ± 17.6 kg initial body wt) fed a forage-based pelleted diet alone ( n = 4) or supplemented with sodium propionate included ( n = 4) for 42 days. High-quality RNA was extracted from the longissimus lumborum and subjected to transcriptome sequencing using RNA-seq technology. Trimmed reads were aligned to the bovine reference genome (Btau4.0, release 63) and uniquely mapped reads from control and propionate treatment groups were subject to further analysis using edgeR. Candidates were filtered to account for multiple testing and differentially expressed genes (153 at a false discovery rate of <5%) were analyzed using Gene Ontology (GO) analysis (GOseq) to select terms where enrichment had occurred. Significant GO terms included regulation of cholesterol transport, regulation of sterol transport, and cellular modified amino acid metabolic process. Furthermore, the top four identified gene networks included lipid metabolism, small molecule biochemistry, carbohydrate metabolism, and molecular transport-related categories. Notably, changes in lipid metabolism specific genes reflect both increased oxidative and lipid synthetic capacities. Metabolism-related gene changes are reflective of expected enhancements in lean tissue accretion patterns exhibited in steers where high ruminal propionate relative to other short chain fatty acids is observed. Propionate feeding induced increased N retention in rapidly growing Angus cattle, and the observed alterations in LL tissue lipid metabolism-related gene networks are consistent with enhanced cell formation and function (protein synthesis, and lipogenic vs. lipolytic activities).

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Myostatin maps to the interval containing the bovine mh locus

Cited by 86 publications

References 11 publications

Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle

Myostatin (GDF8) single nucleotide polymorphisms in Nellore cattle

Influence of breed, heterozygosity, and disease incidence on estimates of variance components of respiratory disease in preweaned beef calves

Characterization of the longissimus lumborum transcriptome response to adding propionate to the diet of growing Angus beef steers

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