Myricetin Attenuates Depressant-Like Behavior in Mice Subjected to Repeated Restraint Stress

Abstract

Increasing evidence has shown that oxidative stress may be implicated in chronic stress-induced depression. Several flavonoids with anti-oxidative effects have been proved to be anti-depressive. Myricetin is a well-defined flavonoid with the anti-oxidative, anti-inflammatory, anti-apoptotic, and neuroprotective properties. The aim of the present study is to investigate the possible effects of chronic administration of myricetin on depressant-like behaviors in mice subjected to repeated restraint (4 h/day) for 21 days. Our results showed that myricetin administration specifically reduced the immobility time in mice exposed to chronic stress, as tested in both forced swimming test and tail suspension test. Myricetin treatment improved activities of glutathione peroxidase (GSH-PX) in the hippocampus of stressed mice. In addition, myricetin treatment decreased plasma corticosterone levels of those mice subjected to repeated restraint stress. The effects of myricetin on the brain-derived neurotrophic factor (BDNF) levels in hippocampus were also investigated. The results revealed that myricetin normalized the decreased BDNF levels in mice subjected to repeated restraint stress. These findings provided more evidence that chronic administration of myricetin improves helpless behaviors. The protective effects of myricetin might be partially mediated by an influence on BDNF levels and might be attributed to myricetin-mediated anti-oxidative stress in the hippocampus.

Chronic Unpredictable Stress-Induced Behavioral and Electrophysiological Alterations and Its Ameliorative Effect by Myricetin Microemulsion

“…This is supported by previous findings, chronic restraint and CUS showed anxiety-like behavior, and this was reduced in the MYR-administrated group [1,31,32]. Riaz et al (2015) reported that CUS-exposed animals showed impaired spatial memory in the eight-arm radial maze [33], this is consistent with the present findings.…”

“…The similar results were observed in the earlier studies, unpredictable subchronic stress affects memory through increased glucocorticoid levels which might have implications for brain plasticity and behavioral changes following the stress in rat's hippocampus [39]. Recognition memory was improved in MYR-ME treated, the possible mechanism could be decreasing corticosterone levels and increasing brain-derived neurotropic factor (BDNF) levels, previous study also reported that chronic restraint stress increased corticosterone levels and decreased BDNF levels, and this was normalized in the MYR treatment animals by attributing to MYRmediated antioxidative stress in the hippocampus [32].…”

Variable Effects of Acoustic Trauma on Behavioral and Neural Correlates of Tinnitus In Individual Animals

“…It has been shown that loud unexpected sounds can raise levels of stress-related hormones (Burow et al, 2005). Both restraint and social stress are common in laboratory animals (Stone and Quartermain, 1997; Ma et al, 2015). Simple handling of an animal, putting it in a new environment, and cage changes can also raise levels of stress in animals (Seggie and Brown, 1975; Duke et al, 2001).…”

Inhibitory Effects of Myricetin on Lipopolysaccharide-Induced Neuroinflammation

“…Furthermore, in mice subjected to restraint stress to induce cognitive deficits and depression, myricetin improved spatial memory and depression-like behavior. Myricetin also normalized the decreased brain-derived neurotrophic factor (BDNF) levels observed in the hippocampus [13,14]. Myricetin was also found to protect 1-methyl-4-phenylpyridinium (MPP+)-treated MES23.5 dopaminergic cells-which exhibit similar properties to primary neurons originating in the substantia nigra, a lesion of PD-by inhibiting MAPK kinase and c-Jun N-terminal kinase (JNK) activation and having an anti-oxidative role [15].…”