Myrislignan Attenuates Lipopolysaccharide‐induced Inflammation Reaction in Murine Macrophage Cells Through Inhibition of NF‐κB Signalling Pathway Activation

Jin, Hong; Zhu, Zuo-Nong; Yu, P.Y.; Wang, Guangfa; Zhang, Junyan; Li, Jing‐Rong; Ai, Ruiting; Li, Zhonghuang; Tian, Yuanxin; Zhang, Wei Xu Jia-Jie; Wu, Shuai

doi:10.1002/ptr.3707

Cited by 34 publications

(19 citation statements)

References 37 publications

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“…TNF‐α and IL‐1β are well‐known proinflammatory cytokines and play a crucial role in inflammation (Smith et al ., ). Plant‐derived compounds belonging to different chemical classes, such as polysaccharides (Yu et al ., ), terpenes (Ferrari et al ., ), phenols (Romano et al ., ), lignans (Jin et al ., ), saponins (Lai et al ., ), and flavonoids (Chao et al ., ) have been shown to inhibit nitric oxide production in macrophages. In this study, we initially suggested that the MeOH extract of D .…”

Section: Discussionmentioning

confidence: 99%

The Neoflavonoid Latifolin Isolated from MeOH Extract ofDalbergia odoriferaAttenuates Inflammatory Responses by Inhibiting NF-κB ActivationviaNrf2-Mediated Heme Oxygenase-1 Expression

Lee

Kim

et al. 2014

Phytother. Res.

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In Korea and China, the heartwood of Dalbergia odorifera T. Chen is an important traditional medicine used to treat blood disorders, ischemia, swelling, and epigastric pain. In this study, we investigated the inhibitory effects of latifolin, a major neoflavonoid component isolated from the MeOH extract of D. odorifera, on the inflammatory reaction of thioglycollate-elicited peritoneal macrophages exposed to lipopolysaccharide, with a particular focus on heme oxygenase-1 (HO-1) expression and nuclear factor-κB (NF-κB) signaling. Latifolin significantly inhibited the protein and mRNA expression of inducible nitric oxide synthase and COX-2, reduced NO, prostaglandins E2, tumor necrosis factor-α, and interleukin-1β production in primary murine peritoneal macrophages exposed to lipopolysaccharide. Latifolin also suppressed inhibitor κB-α levels, NF-κB nuclear translocation, and NF-κB DNA-binding activity. Furthermore, latifolin upregulated HO-1 expression via nuclear transcription factor-E2-related factor 2 (Nrf2) nuclear translocation. In addition, using inhibitor tin protoporphyrin IX (SnPP), an inhibitor of HO-1, it was verified that the inhibitory effects of latifolin on the proinflammatory mediators and NF-κB DNA-binding activity were associated with the HO-1 expression. These results suggested that the latifolin-mediated up-regulation of HO-1 expression played a critical role in anti-inflammatory effects in macrophages. This study therefore identified potent therapeutic effects of latifolin, which warrants further investigation as a potential treatment for inflammatory diseases.

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Section: Discussionmentioning

confidence: 99%

The Neoflavonoid Latifolin Isolated from MeOH Extract ofDalbergia odoriferaAttenuates Inflammatory Responses by Inhibiting NF-κB ActivationviaNrf2-Mediated Heme Oxygenase-1 Expression

Lee

Kim

et al. 2014

Phytother. Res.

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“…Flaxseed represents the highest source of dietary plant lignans, predominantly secoisolariciresinol diglucoside (SDG) (Kuijsten and others ). Flaxseed lignans are metabolized to mammalian lignans, primarily enterolactone (EL) and enterodiol (ED), by colonic microbiota (Duncan and others ), which exert biological activities such as anticancer (Danbara and others ; Qu and others ), antioxidative, antiestrogenic, and anti‐inflammatory activities (Kuijsten and others ; During and others ; Jin and others ). Flaxseed contains 20% to 28% dietary fibers, which have been associated with health benefits such as blood serum cholesterol reduction (Riccioni and others ; Satija and Hu ).…”

Section: Introductionmentioning

confidence: 99%

Flaxseed‐Enriched Cereal‐Based Products: A Review of the Impact of Processing Conditions

Mercier

Villeneuve

Moresoli

et al. 2014

Comp Rev Food Sci Food Safe

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The properties of cereals products, bread, pasta, muffins, cookies, cakes, and bars, enriched with flaxseed, were reviewed to highlight suitable processing conditions for the production of high-quality flaxseed-enriched products with the desired health attributes. The review highlights the contrasting effect of flaxseed enrichment on the mechanical and physical properties of cereal products according to product type, flaxseed enrichment level, and processing history. Flaxseed lipids remain stable for most processing and storage conditions, presumably due to the significant antioxidant properties of lignans, but information is lacking on the impact of home-handling, such as bread toasting, on lipid oxidation. Cereal products enriched with flaxseed generally exhibit similar or improved shelf life compared to equivalent products with no flaxseed enrichment, suggesting that flaxseed may limit starch retrogradation, maintain moisture content, and delay microbial growth. Sensory analysis shows lower organoleptic properties of most cereal products containing flaxseed, but similar consumer acceptance for cereal products without and with flaxseed enrichment up to 15% is reported in the literature. This review indicates the need to better understand the impact of flaxseed enrichment on product microstructure and to conduct an extensive assessment of the health effects of flaxseed-enriched products, since very few studies have focused on the quantification of the bioaccessibility, bioavailability, and activity of flaxseed bioactive compounds for a variety of processing conditions and product formulation.

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“…Thus, acute inflammation is essentially a beneficial process, particularly that which develops in response to infectious pathogens. Chronic inflammation, however, is an undesirable phenomenon and is involved in the pathogenesis of chronic diseases such as cancer, arthritis, autoimmune disorders, and vascular diseases [1–3]. For these reasons, research has focused on the control of inflammatory reactions.…”

Section: Introductionmentioning

confidence: 99%

Sargachromenol from Sargassum micracanthum Inhibits the Lipopolysaccharide‐Induced Production of Inflammatory Mediators in RAW 264.7 Macrophages

Yang

Ham²,

Yang³

et al. 2013

The Scientific World Journal

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During our ongoing screening program designed to determine the anti-inflammatory potential of natural compounds, we isolated sargachromenol from Sargassum micracanthum. In the present study, we investigated the anti-inflammatory effects of sargachromenol on lipopolysaccharide (LPS)-induced inflammation in murine RAW 264.7 macrophage cells and the underlying mechanisms. Sargachromenol significantly inhibited the LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2) in a dose-dependent manner. It also significantly inhibited the protein expression of inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) in a dose-dependent manner in LPS-stimulated macrophage cells. Further analyses showed that sargachromenol decreased the cytoplasmic loss of inhibitor κBα (IκBα) protein. These results suggest that sargachromenol may exert its anti-inflammatory effects on LPS-stimulated macrophage cells by inhibiting the activation of the NF-κB signaling pathway. In conclusion, to our knowledge, this is the first study to show that sargachromenol isolated from S. micracanthum has an effective anti-inflammatory activity. Therefore, sargachromenol might be useful for cosmetic, food, or medical applications requiring anti-inflammatory properties.

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Myrislignan Attenuates Lipopolysaccharide‐induced Inflammation Reaction in Murine Macrophage Cells Through Inhibition of NF‐κB Signalling Pathway Activation

Cited by 34 publications

References 37 publications

The Neoflavonoid Latifolin Isolated from MeOH Extract ofDalbergia odoriferaAttenuates Inflammatory Responses by Inhibiting NF-κB ActivationviaNrf2-Mediated Heme Oxygenase-1 Expression

The Neoflavonoid Latifolin Isolated from MeOH Extract ofDalbergia odoriferaAttenuates Inflammatory Responses by Inhibiting NF-κB ActivationviaNrf2-Mediated Heme Oxygenase-1 Expression

Flaxseed‐Enriched Cereal‐Based Products: A Review of the Impact of Processing Conditions

Sargachromenol from Sargassum micracanthum Inhibits the Lipopolysaccharide‐Induced Production of Inflammatory Mediators in RAW 264.7 Macrophages

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