Myrsine seguinii ethanolic extract and its active component quercetin inhibit macrophage activation and peritonitis induced by LPS by targeting to Syk/Src/IRAK-1

In vitro and in vivo anti-inflammatory activity of Phyllanthus acidus methanolic extract

“…Moreover, pharmacological tests in combination with the NO assay strongly indicated that quercetin is the most likely candidate to mediate the anti-inflammatory actions of Pa-ME (data not shown). In fact, we have also observed that quercetin efficiently inhibits Src and Syk kinase activity (Endale et al, 2013) and reduces the production of inflammatory cytokines and mediators (Yang et al, 2014a(Yang et al, . 2014b).…”

“…Indeed, various studies reported its analgesic, antipyretic, antiviral, anti-allergic, hepatoprotective, anti-hyperlipidemic, anti-cystic fibrosis, and anti-rheumatic activities (Chakraborty et al, 2012;Chongsa et al, 2014;Lee et al, 2006;Sousa et al, 2007;Unander et al, 1995), although molecular mechanisms of therapeutic potential have not been fully elucidated. It is generally accepted that tissue-associated macrophages play a critical role in the loss of organ function, caused to generation of gastritis, arthritis, hepatitis, and colitis in stomach, joints, liver, and colon (Yang et al, 2014a(Yang et al, . 2014bYi et al, 2014;, by releasing toxic and inflammatory molecules such as NO, ROS, PGE 2 , hydrolytic enzymes, and proinflammatory cytokines such as IL-1 and TNF-α .…”

Functional Roles of Syk in Macrophage-Mediated Inflammatory Responses

“…The methanol extract of Archidendron clypearia suppresses the production of NO, PGE 2 , and TNF- α in LPS-stimulated macrophages and ameliorates the symptoms of dextran sodium sulfate (DSS)-induced colitis [82]. The ethanol extract of Myrsine seguinii also suppresses the production of NO, PGE2, and TNF- α in LPS-stimulated macrophages and ameliorates the symptoms of thioglycollate-induced peritonitis [88]. The methanol extract of Rhodomyrtus tomentosa suppresses the production of NO and PGE2 in LPS-stimulated macrophages and ameliorates the symptoms of EtOH/HCl-induced gastritis and DSS-induced colitis [81].…”

Effect of quercetin glucosides from Allium extracts on HepG2, PC‑3 and HT‑29 cancer cell lines

“…The composition of flavonols in genus Allium varies widely depending on the growing conditions and storage (10). Previous animal studies have revealed that quercetin enhanced the antioxidant levels in the plasma (11)(12)(13)(14). Quercetin derivatives have been used in the treatment of peroxynitrite-oxidized sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (SERCA1) (15).…”