"Myxedema Heart" Without Evidence of Cardiac Insufficiency

David Ayman, MD: An Early Investigator of Clinical Hypertension

“…Report of two cases. 25 1932 NF Harmful effects of nitroglycerin. 26 1932 NF The intracutaneous quantitative tuberculin test in the diagnosis of active tuberculosis.…”

“…The opinions and ideas expressed in this publication are those of the authors and do not necessarily reflect those of the Editors or Publisher. For copies in excess of 25 His enduring work centers on two areas: his description of what later became known as "white coat" hypertension and his observations on the family history of hypertension.…”

“…The opinions and ideas expressed in this publication are those of the authors and do not necessarily reflect those of the Editors or Publisher. For copies in excess of 25 a placebo consisting of 10 drops of dilute hydrochloric acid that was to be taken in half a glass of water three times a day before meals. The solution did have a distinctive taste, but was not expected to have any therapeutic benefit.…”

Hypothyroidism Produced by Radioactive Iodine (I 131 ) in the Treatment of Euthyroid Patients with Angina Pectoris and Congestive Heart Failure

“…THE QUESTION OF "THE MYXEDEMA HEART" As in previous studies, particular attention has been devoted to the appearance of evidence of the signs or symptoms of the so-called "myxedema heart." Observations of the heart in spontaneous myxedema34 [46][47][48][49][50][51][52] Krantz,34 however, studied a total of three hundred patients with myxedema and concluded that heart function is rarely, if ever, impaired. From a review of the literature and a comprehensive study of 30 additional cases at the Massachusetts General Hospital, Lerman, Clark and Means49 concluded that "myxedema heart" in the sense of heart failure occurs rarely, if at all-an opinion likewise expressed by Christian.40' 60 Our own observations are in accordance with the latter findings; an increased cardiac silhouette or area of percussion dullness, decreased voltage of the electrocardiogram and less forceful pulsations on fluoroscopy have been observed in some of our subjects.…”

The Heart in Myxedema

“…Ayman, Rosenblum and Falcon-Lesses 12 suggested that enlargement of the heart, with its return to normal fol¬ lowing thyroid treatment, is the one diagnostic feature of the heart in myxedema, since the other abnormalities are usually found in all cases of myxedema. Clinically, the symptoms of decompensation were always mild, edema and congestive failure occurring but seldom.…”