Myxofibrosarcoma of the scalp with difficult preoperative diagnosis: A case report and review of the literature

Ke, Xiao-Ting; Yu, Xiong-Feng; Liu, Jiyang; Huang, Fang; Chen, Mei-Gui; Lai, Qing-Quan

doi:10.12998/wjcc.v8.i11.2350

Cited by 4 publications

(7 citation statements)

References 35 publications

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“…To distinguish neoplasms, the immunohistochemistry panel should be performed. MFS shows consistent immunoreactivity for vimentin (VIM), smooth muscle actin (SMA), CD34, Ki-67 and remains negative for S-100 and glial fibrillary acidic protein (GFAP) [3]. The immunohistochemical analysis was, for our case, nonspecific as it was positive for S100p, CD68, CD34 and low positive for Ki-67.…”

Section: Discussionmentioning

confidence: 75%

“…The head and neck as a primary site are extremely rare with only a few reports being present in literature. Previous cases reported in the region of head and neck included the cranial cavity, orbit, maxilla, parotid gland, hypopharynx, sinus piriformis, vocal folds or thyroid gland [3]. No cases in the region of the temporomandibular joint were found in the literature, to the best of our knowledge.…”

Section: Introductionmentioning

confidence: 79%

“…It most commonly appears in the deep soft tissues of the lower extremities [5] with occurrence in the head and neck site being extremely rare-only about ten reports were found in the literature to the best of our knowledge. In this region, MFS was found in the cranial cavity, orbit, maxilla, parotid gland, hypopharynx, sinus piriformis, vocal folds or thyroid gland [3]. MFS affects mostly elder patients with no specific sex predilections [6].…”

Section: Discussionmentioning

confidence: 99%

“…MFS is described as challenging for diagnosing due to its very variable clinical and histologic presentation [17]. Histologically, MFS myxoid cells are mixed with spindle cells [3]. In the area of spindle cells, there are present large atypical cells and more mitotic features.…”

Section: Discussionmentioning

confidence: 99%

“…H+E staining. A high-grade solid component resembling undifferentiated pleomorphic sarcoma is seen[3] (bottom), juxtaposed to a myxoid matrix[1] area exhibiting typical features of myxofibrosarcoma (moderate cellularity, mild atypia, prominent elongated vessels[2]). Appl.…”

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confidence: 99%

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Myxofibrosarcoma Mimicking Inflammatory Lesion of Temporomandibular Joint—Case Presentation

et al. 2021

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Treating oncologic patients remains a challenge for surgeons aiming to provide patients with safe margins of resection while maintaining the highest possible quality of life. The latter, in the case of malignancies, requires using sophisticated methods of reconstruction. Thus, we present a case of a 75-year-old patient treated in our department with a rare neoplasm in the region of the temporomandibular joint—a myxofibrosarcoma that was mimicking an inflammatory lesion. The patient underwent two surgeries—firstly alloplasty of the TMJ due to the suspicion of an inflammatory lesion, lately extended to the resection of glenoid fossa and subtemporal fossa contents when the mandible was reconstructed using UHMW-PE (ultra-high molecular weight polyethylene). The patient was also referred for adjuvant radiotherapy and has remained disease-free for over 96 months with very good aesthetics and function of the mandible. The presented case highlights not only the need for increased oncologic awareness but also the possible use of UHMW-PE as a reconstruction material in the broad resection of the maxillofacial region.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Myxofibrosarcoma Mimicking Inflammatory Lesion of Temporomandibular Joint—Case Presentation

et al. 2021

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Scalp

Demaerel

2023

Imaging of the Scalp and Calvarium

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Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives

et al. 2022

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Myxofibrosarcoma (MFS) is a common entity of adult soft tissue sarcomas (STS) characterized by a predilection of the extremities and a high local recurrence rate. Originally classified as a myxoid variant of malignant fibrous histiocytoma, this musculoskeletal tumor has been recognized since 2002 as a distinct histotype showing a spectrum of malignant fibroblastic lesions with myxoid stroma, pleomorphism and curvilinear vessels. Currently, the molecular pathogenesis of MFS is still poorly understood and its genomic profile exhibits a complex karyotype with a number of aberrations including amplifications, deletions and loss of function. The diagnosis is challenging due to the unavailability of specific immunohistochemical markers and is based on the analysis of cytomorphologic features. The mainstay of treatment for localized disease is represented by surgical resection, with (neo)-adjuvant radio- and chemotherapy. In the metastatic setting, chemotherapy represents the backbone of treatments, however its role is still controversial and the outcome is very poor. Recent advent of genomic profiling, targeted therapies and larger enrollment of patients in translational and clinical studies, have improved the understanding of biological behavior and clinical outcome of such a disease. This review will provide an overview of current diagnostic pitfalls and clinical management of MFS. Finally, a look at future directions will be discussed.

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Myxofibrosarcoma of the scalp with difficult preoperative diagnosis: A case report and review of the literature

Cited by 4 publications

References 35 publications

Myxofibrosarcoma Mimicking Inflammatory Lesion of Temporomandibular Joint—Case Presentation

Myxofibrosarcoma Mimicking Inflammatory Lesion of Temporomandibular Joint—Case Presentation

Scalp

Myxofibrosarcoma landscape: diagnostic pitfalls, clinical management and future perspectives

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